AIM:To determine the efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy.METHODS: A prospective, double-blind, randomized, placebo-controlled study was conduct...AIM:To determine the efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy.METHODS: A prospective, double-blind, randomized, placebo-controlled study was conducted on 70 patients who underwent elective laparoscopic cholecystectomy under general anesthesia at Siriraj Hospital, Bangkok, from January 2006 to December 2007. Patients were randomized to receive either 20 mg parecoxib infusion 30 min before induction of anesthesia and at 12 h after the first dose (treatment group), or normal saline infusion, in the same schedule, as a placebo (control group). The degree of the postoperative pain was assessed every 3 h in the first 24 h after surgery, and then every 12 h the following day, using a visual analog scale. The consumption of analgesics was also recorded.RESULTS:There were 40 patients in the treatment group, and 30 patients in the control group. The pain scores at each time point, and analgesic consumption did not differ between the two groups. However,there were fewer patients in the treatment group than placebo group who required opioid infusion within the first 24 h (60% vs 37%, P=0.053).CONCLUSION: Perioperative administration of parecoxib provided no significant effect on postoperative pain relief after laparoscopic cholecystectomy. However, preoperative infusion 20 mg parecoxib could significantly reduce the postoperative opioid consumption.展开更多
目的探究快速康复外科理念在甲状腺癌根治术围手术期中的应用效果。方法选取西安交通大学第一附属医院耳鼻咽喉-头颈外科2015年2月至2016年10月接受根治术治疗的106例甲状腺癌患者为研究对象,2015年2月至2015年9月间收治53例进行常规护...目的探究快速康复外科理念在甲状腺癌根治术围手术期中的应用效果。方法选取西安交通大学第一附属医院耳鼻咽喉-头颈外科2015年2月至2016年10月接受根治术治疗的106例甲状腺癌患者为研究对象,2015年2月至2015年9月间收治53例进行常规护理作为对照组;2015年10月至2016年10月间收治53例在常规护理的基础上给予快速康复外科理念干预护理,比较护理效果。结果观察组患者的下床时间[(2.46±0.61)d vs(4.12±0.68)d]、住院时间[(8.01±0.75)d vs(5.04±0.82)d]、住院费用[(0.51±0.11)万元vs(0.72±0.12)万元]均明显低于对照组,比较差异有统计学意义(P均<0.01),观察组患者的切口感染、声音嘶哑、喉返神经损伤等总并发症发生率低于对照组,差异有统计学意义(0 vs 20.75%,P<0.01),观察组患者的术后1、3、5 d的自我护理能力明显高于对照组,比较差异有统计学意义(P均<0.01),而视觉模拟评分法(VAS评分)明显低于对照组,比较差异具有统计学意义(1.56±0.24 vs 3.42±0.21,P<0.01)。结论对采用根治术治疗的甲状腺癌症患者予以快速康复外科理念干预,能够有效改善患者的各项住院指标,降低并发症的发生率,提升康复效果,缩短康复时间。展开更多
基金Supported by Faculty of Medicine Siriraj Hospital Research Project Grant
文摘AIM:To determine the efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy.METHODS: A prospective, double-blind, randomized, placebo-controlled study was conducted on 70 patients who underwent elective laparoscopic cholecystectomy under general anesthesia at Siriraj Hospital, Bangkok, from January 2006 to December 2007. Patients were randomized to receive either 20 mg parecoxib infusion 30 min before induction of anesthesia and at 12 h after the first dose (treatment group), or normal saline infusion, in the same schedule, as a placebo (control group). The degree of the postoperative pain was assessed every 3 h in the first 24 h after surgery, and then every 12 h the following day, using a visual analog scale. The consumption of analgesics was also recorded.RESULTS:There were 40 patients in the treatment group, and 30 patients in the control group. The pain scores at each time point, and analgesic consumption did not differ between the two groups. However,there were fewer patients in the treatment group than placebo group who required opioid infusion within the first 24 h (60% vs 37%, P=0.053).CONCLUSION: Perioperative administration of parecoxib provided no significant effect on postoperative pain relief after laparoscopic cholecystectomy. However, preoperative infusion 20 mg parecoxib could significantly reduce the postoperative opioid consumption.
文摘目的探究快速康复外科理念在甲状腺癌根治术围手术期中的应用效果。方法选取西安交通大学第一附属医院耳鼻咽喉-头颈外科2015年2月至2016年10月接受根治术治疗的106例甲状腺癌患者为研究对象,2015年2月至2015年9月间收治53例进行常规护理作为对照组;2015年10月至2016年10月间收治53例在常规护理的基础上给予快速康复外科理念干预护理,比较护理效果。结果观察组患者的下床时间[(2.46±0.61)d vs(4.12±0.68)d]、住院时间[(8.01±0.75)d vs(5.04±0.82)d]、住院费用[(0.51±0.11)万元vs(0.72±0.12)万元]均明显低于对照组,比较差异有统计学意义(P均<0.01),观察组患者的切口感染、声音嘶哑、喉返神经损伤等总并发症发生率低于对照组,差异有统计学意义(0 vs 20.75%,P<0.01),观察组患者的术后1、3、5 d的自我护理能力明显高于对照组,比较差异有统计学意义(P均<0.01),而视觉模拟评分法(VAS评分)明显低于对照组,比较差异具有统计学意义(1.56±0.24 vs 3.42±0.21,P<0.01)。结论对采用根治术治疗的甲状腺癌症患者予以快速康复外科理念干预,能够有效改善患者的各项住院指标,降低并发症的发生率,提升康复效果,缩短康复时间。
