Uterine leiomyoma with lymphoid infiltration is a rare disease that simulates malignant lymphoma with only nine cases reported to date. We describe the first case of uterine adenomyoma with lymphoid infiltration simul...Uterine leiomyoma with lymphoid infiltration is a rare disease that simulates malignant lymphoma with only nine cases reported to date. We describe the first case of uterine adenomyoma with lymphoid infiltration simulating lymphoma. The specimen resected from a 30- year- old Chinese woman was a well defined firm nodule measuring 5 . A- 5.5 cm. The cut A- 5.5 .surface was similar to that of adenomyoma, which contained dark brown spots and a cyst. Microscopically, the tumor comprised smooth muscle cells intermixed with many lymphocytes. Many lymphoid follicles were present, just locating beside one side of thin walled blood vessels and protruding into the vessels. Endometrial type glands and stroma were visible in the tumor. We describe the first case of uterine adenomyoma with lymphoid infiltration simulating lymphoma.展开更多
A 45-year-old woman from Afghanistan presented with a 1year history of multiple itching and stinging lesions on both right and left auricular and periauricular areas. Skin examination revealed about eight superficial ...A 45-year-old woman from Afghanistan presented with a 1year history of multiple itching and stinging lesions on both right and left auricular and periauricular areas. Skin examination revealed about eight superficial erythematous nodules, ranging from 0.2 to 1.2 cm in diameter, on both ears, as well as on the preauricular and retroauricular areas (Fig. 1). Examination of a lesional skin biopsy specimen revealed vascular proliferation and dense dermal infiltration by lymphocytes, eosinophils, and mast cells. The vascular component consisted of thick- and thin- walled blood vessels lined by plump endothelial cells with large nuclei and abundant eosinophilic cytoplasm. No lymphoid follicles were identified (Fig. 2). The patient’ s medical history was remarkable for the gradual development of generalized edema starting 4 months after the appearance of the skin lesions. Laboratory investigation revealed the presence of massive proteinuria (11 g/day; normal,<150 mg/day) and he- maturia (12 red blood cells/high- power field; normal,<1- 2red blood cells/high- power field), in association with hypoproteinemia (3.7 g/dL; normal, 5.5- 8 g/dL and hypercholesterolemia (489 mg/dL; normal, 50- 220 mg/dL). The blood urea nitrogen (14 mg/dL; normal, 5- 23 mg/dL) and serum creatinine (0.8 mg/dL; normal, 0.6- 1.6 mg/dL) levels were within normal limits. A pathologic study of a renal biopsy specimen confirmed the diagnosis of diffuse mesangial proliferative nephropathy (Fig. 3).展开更多
文摘Uterine leiomyoma with lymphoid infiltration is a rare disease that simulates malignant lymphoma with only nine cases reported to date. We describe the first case of uterine adenomyoma with lymphoid infiltration simulating lymphoma. The specimen resected from a 30- year- old Chinese woman was a well defined firm nodule measuring 5 . A- 5.5 cm. The cut A- 5.5 .surface was similar to that of adenomyoma, which contained dark brown spots and a cyst. Microscopically, the tumor comprised smooth muscle cells intermixed with many lymphocytes. Many lymphoid follicles were present, just locating beside one side of thin walled blood vessels and protruding into the vessels. Endometrial type glands and stroma were visible in the tumor. We describe the first case of uterine adenomyoma with lymphoid infiltration simulating lymphoma.
文摘A 45-year-old woman from Afghanistan presented with a 1year history of multiple itching and stinging lesions on both right and left auricular and periauricular areas. Skin examination revealed about eight superficial erythematous nodules, ranging from 0.2 to 1.2 cm in diameter, on both ears, as well as on the preauricular and retroauricular areas (Fig. 1). Examination of a lesional skin biopsy specimen revealed vascular proliferation and dense dermal infiltration by lymphocytes, eosinophils, and mast cells. The vascular component consisted of thick- and thin- walled blood vessels lined by plump endothelial cells with large nuclei and abundant eosinophilic cytoplasm. No lymphoid follicles were identified (Fig. 2). The patient’ s medical history was remarkable for the gradual development of generalized edema starting 4 months after the appearance of the skin lesions. Laboratory investigation revealed the presence of massive proteinuria (11 g/day; normal,<150 mg/day) and he- maturia (12 red blood cells/high- power field; normal,<1- 2red blood cells/high- power field), in association with hypoproteinemia (3.7 g/dL; normal, 5.5- 8 g/dL and hypercholesterolemia (489 mg/dL; normal, 50- 220 mg/dL). The blood urea nitrogen (14 mg/dL; normal, 5- 23 mg/dL) and serum creatinine (0.8 mg/dL; normal, 0.6- 1.6 mg/dL) levels were within normal limits. A pathologic study of a renal biopsy specimen confirmed the diagnosis of diffuse mesangial proliferative nephropathy (Fig. 3).
