布里昂酒庄的香槟佳酿尊重大自然和土地是布里昂香槟酒庄(Champagne Leclerc Briant)一直奉行的理念,酒庄的葡萄园都采用有机和生物动力学农业模式进行耕作,酒庄现在种植了14公顷的葡萄园,主要位于特级园(Mailly Le Mesnil)和一级园(Hua...布里昂酒庄的香槟佳酿尊重大自然和土地是布里昂香槟酒庄(Champagne Leclerc Briant)一直奉行的理念,酒庄的葡萄园都采用有机和生物动力学农业模式进行耕作,酒庄现在种植了14公顷的葡萄园,主要位于特级园(Mailly Le Mesnil)和一级园(Huautillers.Cumieres.Mareuil sur Ay.Bisseuil、Rlly la Montagne、Vllers Alerand.Teail),酒庄位于面向兰斯山脉和马恩河谷的城镇上,种植着酿造香槟的三种经典葡萄品种:黑比诺、莫尼耶比诺和霞多丽。布里昂香槟酒庄还通过从大约10位合作葡萄种植者那里购买优质的葡萄来近一步优化和多样化其香槟供应,相当于增加了15公顷葡萄园的收成。展开更多
Objective: To evaluate the 24-hour efficacy of brimonidine purite versus dorz olamide, each added to latanoprost. Design: Double-masked, 2-center, prospecti ve, crossover comparison. Participants: Primary open-angle g...Objective: To evaluate the 24-hour efficacy of brimonidine purite versus dorz olamide, each added to latanoprost. Design: Double-masked, 2-center, prospecti ve, crossover comparison. Participants: Primary open-angle glaucoma (POAG) subj ects. Methods: Subjects were randomized to brimonidine purite or dorzolamide, ea ch given twice daily, for the first 6-week treatment period after a 6-week lat anoprost run-in. Subjects began the opposite treatment for the second 6-week p eriod after a 6-week latanoprost-only treatment between periods. Intraocular p ressure (IOP) was measured at 8 am, 12 pm, 4 pm, 8 pm, 12 am, 4 am, and 8 am at each baseline and at the end of each treatment period. This study provided an 80 %power that a 1.5-mmHg difference could be excluded between groups if 27 subje cts completed the study. A standard deviation (SD) of 2.8 mmHg was assumed. Main Outcome Measures: Twentyfour-hour efficacy of intraocular pressures of brimoni dine purite versus dorzolamide, each added to latanoprost. Results: In 31 comple ted subjects, the baseline mean diurnal 24-hour IOP (±SD) was 19.0±1.7 mmHg f or brimonidine purite and 19.0±1.6 mmHg for dorzolamide (P=0.52). The 8 am IOP after 6 weeks of therapy was 18.4±2.1 mmHg for brimonidine purite and 18.9±1.9 mmHg for dorzolamide (P=0.40). The mean diurnal IOP was 16.9±1.5 mmHg for brim onidine purite and 16.8±1.5 mmHg for dorzolamide (P=0.66). Dorzolamide caused a more bitter taste (P=0.01) than brimonidine purite. Conclusions: This study sug gests that brimonidine purite and dorzolamide, added to latanoprost, have simila r efficacy and safety in POAG or ocular hypertensive subjects.展开更多
文摘布里昂酒庄的香槟佳酿尊重大自然和土地是布里昂香槟酒庄(Champagne Leclerc Briant)一直奉行的理念,酒庄的葡萄园都采用有机和生物动力学农业模式进行耕作,酒庄现在种植了14公顷的葡萄园,主要位于特级园(Mailly Le Mesnil)和一级园(Huautillers.Cumieres.Mareuil sur Ay.Bisseuil、Rlly la Montagne、Vllers Alerand.Teail),酒庄位于面向兰斯山脉和马恩河谷的城镇上,种植着酿造香槟的三种经典葡萄品种:黑比诺、莫尼耶比诺和霞多丽。布里昂香槟酒庄还通过从大约10位合作葡萄种植者那里购买优质的葡萄来近一步优化和多样化其香槟供应,相当于增加了15公顷葡萄园的收成。
文摘Objective: To evaluate the 24-hour efficacy of brimonidine purite versus dorz olamide, each added to latanoprost. Design: Double-masked, 2-center, prospecti ve, crossover comparison. Participants: Primary open-angle glaucoma (POAG) subj ects. Methods: Subjects were randomized to brimonidine purite or dorzolamide, ea ch given twice daily, for the first 6-week treatment period after a 6-week lat anoprost run-in. Subjects began the opposite treatment for the second 6-week p eriod after a 6-week latanoprost-only treatment between periods. Intraocular p ressure (IOP) was measured at 8 am, 12 pm, 4 pm, 8 pm, 12 am, 4 am, and 8 am at each baseline and at the end of each treatment period. This study provided an 80 %power that a 1.5-mmHg difference could be excluded between groups if 27 subje cts completed the study. A standard deviation (SD) of 2.8 mmHg was assumed. Main Outcome Measures: Twentyfour-hour efficacy of intraocular pressures of brimoni dine purite versus dorzolamide, each added to latanoprost. Results: In 31 comple ted subjects, the baseline mean diurnal 24-hour IOP (±SD) was 19.0±1.7 mmHg f or brimonidine purite and 19.0±1.6 mmHg for dorzolamide (P=0.52). The 8 am IOP after 6 weeks of therapy was 18.4±2.1 mmHg for brimonidine purite and 18.9±1.9 mmHg for dorzolamide (P=0.40). The mean diurnal IOP was 16.9±1.5 mmHg for brim onidine purite and 16.8±1.5 mmHg for dorzolamide (P=0.66). Dorzolamide caused a more bitter taste (P=0.01) than brimonidine purite. Conclusions: This study sug gests that brimonidine purite and dorzolamide, added to latanoprost, have simila r efficacy and safety in POAG or ocular hypertensive subjects.
