Background and Purpose:Functional outcome scales are typically used to measur e quality of life (QOL) and outcomes in patients with cerebral aneurysms; howeve r, these instruments only examine a limited number of doma...Background and Purpose:Functional outcome scales are typically used to measur e quality of life (QOL) and outcomes in patients with cerebral aneurysms; howeve r, these instruments only examine a limited number of domains that contribute to QOL. An alternative are preference-based QOL methods,which integrate all facto rs contributing to QOL and provide a comprehensive individualized measure of how patients value their current health state. An additional advantage of preferenc e-based QOL values is that they can be incorporated into decision analyses and cost-effectiveness analyses. Methods:We used 4 preference-based QOL methods t o measure QOL in176 outpatients with cerebral aneurysms: (1) standard gamble;(2) time trade-off; (3) visual analogue scale; and (4) willingness to pay. We meas ured functional status with the Glasgow Outcome Scale (GOS), Rankin Scale, and B arthel Index. We then built multivariate linear regression models to examine the relationships between preference-based QOL, functional status,and patient char acteristics. Results:Preference-based QOL was moderately diminished in the ane urysm patients. Mean values were; standard gamble, 0.78; time trade-off, 0.79; visual analogue scale, 0.67; and willingness to pay, ＄121 000. Preference-base d QOL was not well-explained by functional status or patient characteristics, a s shown by regression models that accounted for < 15%of the variation in prefer ence-based QOL (R2 < 0.15). Conclusions:Preference-based QOL instrument scapt ure components of QOL in patients with cerebral aneurysms not assessed by functi onal status measures or patient characteristics.Studies of patients with cerebra l aneurysms should consider incorporating preference-based QOL measures for a f uller evaluation of the impact of aneurysmal disease and its treatment on QOL.展开更多
文摘Background and Purpose:Functional outcome scales are typically used to measur e quality of life (QOL) and outcomes in patients with cerebral aneurysms; howeve r, these instruments only examine a limited number of domains that contribute to QOL. An alternative are preference-based QOL methods,which integrate all facto rs contributing to QOL and provide a comprehensive individualized measure of how patients value their current health state. An additional advantage of preferenc e-based QOL values is that they can be incorporated into decision analyses and cost-effectiveness analyses. Methods:We used 4 preference-based QOL methods t o measure QOL in176 outpatients with cerebral aneurysms: (1) standard gamble;(2) time trade-off; (3) visual analogue scale; and (4) willingness to pay. We meas ured functional status with the Glasgow Outcome Scale (GOS), Rankin Scale, and B arthel Index. We then built multivariate linear regression models to examine the relationships between preference-based QOL, functional status,and patient char acteristics. Results:Preference-based QOL was moderately diminished in the ane urysm patients. Mean values were; standard gamble, 0.78; time trade-off, 0.79; visual analogue scale, 0.67; and willingness to pay, ＄121 000. Preference-base d QOL was not well-explained by functional status or patient characteristics, a s shown by regression models that accounted for < 15%of the variation in prefer ence-based QOL (R2 < 0.15). Conclusions:Preference-based QOL instrument scapt ure components of QOL in patients with cerebral aneurysms not assessed by functi onal status measures or patient characteristics.Studies of patients with cerebra l aneurysms should consider incorporating preference-based QOL measures for a f uller evaluation of the impact of aneurysmal disease and its treatment on QOL.
