Background: The pulsed dye laser (PDL) is the treatment of choice for port wine stains (PWS); however, some patients’ PWS become refractory to further treatments. Technological advances have enabled new machines with...Background: The pulsed dye laser (PDL) is the treatment of choice for port wine stains (PWS); however, some patients’ PWS become refractory to further treatments. Technological advances have enabled new machines with the advent of surface cooling devices to deliver longer wavelengths and higher fluence more safely. These advances have the potential to achieve improved response rates in refractory PWS. There are few studies comparing the efficacy of standard PDL treatments for refractory PWS with the wider choice of treatment variables available from newer PDL machines. Objectives: To determine if there is any advantage of using a longer wave length (595 nm) and pulse widths (1.5 ms, 6 ms and 20 ms) over conventional PDL settings (wavelength 585 nm, pulse width 1.5 ms) in refractory PWS. Methods: Eighteen consecutive consenting patients with Fitzpatrick skin types 1.4 with a mean age 35 years (range 17- 59 years) with refractory PWS were treated routinely with three separate test areas using 595- nm PDL (using three different pulse width settings of 1.5 ms, 6 ms and 20 ms), compared with test areas treated with 585- nm PDL (pulse width 1.5 ms). All test areas were treated with an identical fluence (15 J cm- 2), spot size (7 mm) and cooling setting (dynamic cooling 60 ms, delay 60 ms). Results: We found a statistically significant advantage of 595- nm PDL (pulse width 1.5 ms) over 595- nm PDL (pulse width 6 ms) (P < 0.05) in the treatment of refractory PWS; however, we found no significant advantage using longer pulse widths of 20 ms compared with 1.5 ms with the 595- nm PDL. There was no statistically significant advantage in using a 595- nm PDL over a 585- nm PDL using identical pulse widths of 1.5 ms, spot size, fluence and cryogen cooling settings; however, the number of directly comparable test areas was smaller. Some individual patients in our study obtained a better response with certain 595- nm PDL settings (pulse width 1.5 ms and 6 ms) compared with 585- nm PDL (pulse width 1.5 ms). Conclusions: Our expe展开更多
TN248.33 2000031659闪光灯泵浦长脉冲染料激光器的实验研究=Experimentalinvestigation of long pulse dye lasers with flashlamp pumping[刊,中]/张军,许凤明,邵中兴,顾华东(中科院长春光机所.吉林,长春(130022))//光学精密工程.—19...TN248.33 2000031659闪光灯泵浦长脉冲染料激光器的实验研究=Experimentalinvestigation of long pulse dye lasers with flashlamp pumping[刊,中]/张军,许凤明,邵中兴,顾华东(中科院长春光机所.吉林,长春(130022))//光学精密工程.—1999,7(3).—38-42从实验的角度出发,研究了分别添加氧气和环辛四烯两种染料三重态猝灭剂后。展开更多
文摘Background: The pulsed dye laser (PDL) is the treatment of choice for port wine stains (PWS); however, some patients’ PWS become refractory to further treatments. Technological advances have enabled new machines with the advent of surface cooling devices to deliver longer wavelengths and higher fluence more safely. These advances have the potential to achieve improved response rates in refractory PWS. There are few studies comparing the efficacy of standard PDL treatments for refractory PWS with the wider choice of treatment variables available from newer PDL machines. Objectives: To determine if there is any advantage of using a longer wave length (595 nm) and pulse widths (1.5 ms, 6 ms and 20 ms) over conventional PDL settings (wavelength 585 nm, pulse width 1.5 ms) in refractory PWS. Methods: Eighteen consecutive consenting patients with Fitzpatrick skin types 1.4 with a mean age 35 years (range 17- 59 years) with refractory PWS were treated routinely with three separate test areas using 595- nm PDL (using three different pulse width settings of 1.5 ms, 6 ms and 20 ms), compared with test areas treated with 585- nm PDL (pulse width 1.5 ms). All test areas were treated with an identical fluence (15 J cm- 2), spot size (7 mm) and cooling setting (dynamic cooling 60 ms, delay 60 ms). Results: We found a statistically significant advantage of 595- nm PDL (pulse width 1.5 ms) over 595- nm PDL (pulse width 6 ms) (P < 0.05) in the treatment of refractory PWS; however, we found no significant advantage using longer pulse widths of 20 ms compared with 1.5 ms with the 595- nm PDL. There was no statistically significant advantage in using a 595- nm PDL over a 585- nm PDL using identical pulse widths of 1.5 ms, spot size, fluence and cryogen cooling settings; however, the number of directly comparable test areas was smaller. Some individual patients in our study obtained a better response with certain 595- nm PDL settings (pulse width 1.5 ms and 6 ms) compared with 585- nm PDL (pulse width 1.5 ms). Conclusions: Our expe
文摘TN248.33 2000031659闪光灯泵浦长脉冲染料激光器的实验研究=Experimentalinvestigation of long pulse dye lasers with flashlamp pumping[刊,中]/张军,许凤明,邵中兴,顾华东(中科院长春光机所.吉林,长春(130022))//光学精密工程.—1999,7(3).—38-42从实验的角度出发,研究了分别添加氧气和环辛四烯两种染料三重态猝灭剂后。
