Background: Rheumatoid factor isotypes and anti-agalactosyl IgG antibodies (anti-AG IgG) have been reported to be detected and correlated with the diseas e activity in some collagen diseases. Objectives: To study the ...Background: Rheumatoid factor isotypes and anti-agalactosyl IgG antibodies (anti-AG IgG) have been reported to be detected and correlated with the diseas e activity in some collagen diseases. Objectives: To study the frequency and the clinical significance of IgM, IgG and IgA rheumatoid factor (IgM-RF, IgG-RF and IgA-RF) and anti-AGIgGin patientswith systemic sclerosis (SSc). Methods : Seventy-nine serum samples from patients with SSc were examined by specific enzyme-linked immunosorbent assays. Results: The levels of IgM-, IgG-, IgA -RF and anti-AG IgG were significantly higher in SSc patients than in normal healthy controls. The levels of IgM-and IgA-RF were significantly higher in patients with diffuse cutaneous SSc than in those with limited cutaneous SSc. I gM-, IgG-and IgA-RF and anti-AG IgG were significantly elevated in 39% , 32% , 23% and 35% of 79 SSc patients, respectively. The prevalence of pul monary fibrosis,oesophageal involvement and cutaneous telangectasias in patients with elevated IgA-RF levels was significantly higher than in those with norma l levels. The incidence of pitting scars of digits in those with elevated IgG- RF levels and the incidence of contracture of phalanges in those with elevated I gM-RF levels were significantly higher than in those with normal levels. The f requency of increased erythrocyte sedimentation rate in patientswith elevated Ig G-RF and the frequency of increased C-reactive protein in those with elevate d IgM-RF were significantly greater than in those with normal levels. Conclusi ons: IgM-, IgG-, IgA-RF and anti-AG IgG can be serum indicators of speci fic clinical manifestations in SSc patients.展开更多
文摘Background: Rheumatoid factor isotypes and anti-agalactosyl IgG antibodies (anti-AG IgG) have been reported to be detected and correlated with the diseas e activity in some collagen diseases. Objectives: To study the frequency and the clinical significance of IgM, IgG and IgA rheumatoid factor (IgM-RF, IgG-RF and IgA-RF) and anti-AGIgGin patientswith systemic sclerosis (SSc). Methods : Seventy-nine serum samples from patients with SSc were examined by specific enzyme-linked immunosorbent assays. Results: The levels of IgM-, IgG-, IgA -RF and anti-AG IgG were significantly higher in SSc patients than in normal healthy controls. The levels of IgM-and IgA-RF were significantly higher in patients with diffuse cutaneous SSc than in those with limited cutaneous SSc. I gM-, IgG-and IgA-RF and anti-AG IgG were significantly elevated in 39% , 32% , 23% and 35% of 79 SSc patients, respectively. The prevalence of pul monary fibrosis,oesophageal involvement and cutaneous telangectasias in patients with elevated IgA-RF levels was significantly higher than in those with norma l levels. The incidence of pitting scars of digits in those with elevated IgG- RF levels and the incidence of contracture of phalanges in those with elevated I gM-RF levels were significantly higher than in those with normal levels. The f requency of increased erythrocyte sedimentation rate in patientswith elevated Ig G-RF and the frequency of increased C-reactive protein in those with elevate d IgM-RF were significantly greater than in those with normal levels. Conclusi ons: IgM-, IgG-, IgA-RF and anti-AG IgG can be serum indicators of speci fic clinical manifestations in SSc patients.
