目的评价CT导向下125I粒子植入治疗胰腺癌的临床价值。方法回顾性分析2003年6月至2004年5月中山大学肿瘤防治中心26例经CT导向下125I粒子植入治疗胰腺癌患者的临床资料,重点总结此手术的经验和技巧。本组26例中,男21例,女5例,年龄47~73...目的评价CT导向下125I粒子植入治疗胰腺癌的临床价值。方法回顾性分析2003年6月至2004年5月中山大学肿瘤防治中心26例经CT导向下125I粒子植入治疗胰腺癌患者的临床资料,重点总结此手术的经验和技巧。本组26例中,男21例,女5例,年龄47~73岁。中位年龄为60岁±13岁。病灶平均直径为6·1(1·0~8·5)cm。其中腹痛较剧者15例,黄疸10例。全部病例经CT、MRI检查(14例)或病理穿刺活检(12例)后临床诊断为胰腺癌。病理分期(TNM,pTNM)Ⅱ期3例,Ⅲ期20例,Ⅳ期3例。采用计算机立体定位计划系统(treatment plan system,TPS)计算布源,在CT导向下将125I粒子植入胰腺瘤灶内,采用(2·2~3·3)×107Mq活度的125I粒子相隔1·0~1·5cm平面播植。125I在1·7cm内具有杀灭肿瘤的作用。结果9例患者疼痛完全缓解,2例部分缓解,4例无效,平均术后3~7d疼痛缓解。4例死于局部进展,2例死于远处转移,全组中位生存时间11个月。2个月后CT复查,完全缓解(CR)2例;部分缓解(PR)13例;无变化(NC)5例;进展(PD)6例。总有效率(CR+PR)57·7%。2个月随访过程中发现3粒粒子(2例患者)迁徙至肝脏内;白细胞轻度下降1例。未见胰瘘、胰腺炎、肠出血、腹腔内脓肿等严重并发症。结论CT导向下放射性粒子植入治疗胰腺癌创伤小,并发症发生率低,生活质量改善明显,近期效果好,具有很好的姑息止痛疗效,是一种治疗中晚期胰腺癌的简单、安全、有效的方法。展开更多
AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare disease.METHODS: We retrospectively revi...AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare disease.METHODS: We retrospectively reviewed a series of seven patients with SPT managed in our hospital between July 1990 and October 2003. Six females and one male with mean age of 31 years (range 13 to 50 years) were diagnosed with SPT at our institution.RESULTS: Clinical presentation included a palpable abdominal mass in two patients and vague abdominal discomfort in another two. Two patients were asymptomatic;their tumors were found incidentally on abdominal sonographic examination for other reasons. The final patient was admitted with hemoperitoneum secondary to tumor rupture. The mean diameter of the tumors in the seven patients was 10.5 cm (range 5 to 20 cm). The lesions were located in the body and tail in five cases and in the head of the pancreas in two. Surgical procedures included distal pancreatectomy (3), distal pancreatectomy with splenectomy (2), pancreaticoduodenectomy (1) and a pylorus-preserving Whipple procedure (1). There were gross adhesions or histological evidence of infiltration to the adjacent pancreas and/or splenic capsule in four cases. None of the patients received adjuvant therapy.The mean follow up was 7 years (range 0.5 to 14 years).One patient developed multiple liver metastases after 14 years of follow up.CONCLUSION: SPT is a rare tumor that behaves less aggressively than other pancreatic tumor. However, in cases with local invasion, long-term follow up is advisable.展开更多
文摘目的评价CT导向下125I粒子植入治疗胰腺癌的临床价值。方法回顾性分析2003年6月至2004年5月中山大学肿瘤防治中心26例经CT导向下125I粒子植入治疗胰腺癌患者的临床资料,重点总结此手术的经验和技巧。本组26例中,男21例,女5例,年龄47~73岁。中位年龄为60岁±13岁。病灶平均直径为6·1(1·0~8·5)cm。其中腹痛较剧者15例,黄疸10例。全部病例经CT、MRI检查(14例)或病理穿刺活检(12例)后临床诊断为胰腺癌。病理分期(TNM,pTNM)Ⅱ期3例,Ⅲ期20例,Ⅳ期3例。采用计算机立体定位计划系统(treatment plan system,TPS)计算布源,在CT导向下将125I粒子植入胰腺瘤灶内,采用(2·2~3·3)×107Mq活度的125I粒子相隔1·0~1·5cm平面播植。125I在1·7cm内具有杀灭肿瘤的作用。结果9例患者疼痛完全缓解,2例部分缓解,4例无效,平均术后3~7d疼痛缓解。4例死于局部进展,2例死于远处转移,全组中位生存时间11个月。2个月后CT复查,完全缓解(CR)2例;部分缓解(PR)13例;无变化(NC)5例;进展(PD)6例。总有效率(CR+PR)57·7%。2个月随访过程中发现3粒粒子(2例患者)迁徙至肝脏内;白细胞轻度下降1例。未见胰瘘、胰腺炎、肠出血、腹腔内脓肿等严重并发症。结论CT导向下放射性粒子植入治疗胰腺癌创伤小,并发症发生率低,生活质量改善明显,近期效果好,具有很好的姑息止痛疗效,是一种治疗中晚期胰腺癌的简单、安全、有效的方法。
文摘AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare disease.METHODS: We retrospectively reviewed a series of seven patients with SPT managed in our hospital between July 1990 and October 2003. Six females and one male with mean age of 31 years (range 13 to 50 years) were diagnosed with SPT at our institution.RESULTS: Clinical presentation included a palpable abdominal mass in two patients and vague abdominal discomfort in another two. Two patients were asymptomatic;their tumors were found incidentally on abdominal sonographic examination for other reasons. The final patient was admitted with hemoperitoneum secondary to tumor rupture. The mean diameter of the tumors in the seven patients was 10.5 cm (range 5 to 20 cm). The lesions were located in the body and tail in five cases and in the head of the pancreas in two. Surgical procedures included distal pancreatectomy (3), distal pancreatectomy with splenectomy (2), pancreaticoduodenectomy (1) and a pylorus-preserving Whipple procedure (1). There were gross adhesions or histological evidence of infiltration to the adjacent pancreas and/or splenic capsule in four cases. None of the patients received adjuvant therapy.The mean follow up was 7 years (range 0.5 to 14 years).One patient developed multiple liver metastases after 14 years of follow up.CONCLUSION: SPT is a rare tumor that behaves less aggressively than other pancreatic tumor. However, in cases with local invasion, long-term follow up is advisable.
