AIM:To study the relative efficacy of cisapride, metoclopramide,domperidone,erythromycin and mosapride on gastric emptying(GE)and small intestinal transit(SIT) in morphine treated mice. METHODS:Phenol red marker meal ...AIM:To study the relative efficacy of cisapride, metoclopramide,domperidone,erythromycin and mosapride on gastric emptying(GE)and small intestinal transit(SIT) in morphine treated mice. METHODS:Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either sex.The groups included were control,morphine 1 mg/kg(s.c.15 rain before test meal)alone or with(45 rain before test meal p.o.)cisapride 10 mg/kg,metoclopramide 20 mg/kg, domperidone 20 mg/kg,erythromycin 6 mg/kg and mosapride 20 mg/kg. RESULTS:Cisapride,metoclopramide and mosapride were effective in enhancing gastric emptying significantly(P<0.001) whereas other prokinetic agents failed to do so in normal mice.Metoclopramide completely reversed morphine induced delay in gastric emptying followed by mosapride. Metoclopramide alone was effective when given to normal mice in increasing the SIT.Cisapride,though it did not show any significant effect on SIT in normal mice,was able to reverse morphine induced delay in SIT significantly(P<0.001) followed by metoclopramide and mosapride. CONCLUSION:Metoclopramide and cisapride are most effective in reversing morphine-induced delay in gastric emptying and small intestinal transit in mice respectively.展开更多
目的探讨检查前口服莫沙比利对胶囊内镜检查中胃排空时间、小肠通过时间及胶囊排出时间的影响。方法将我院2007年3月-2008年5月间做胶囊内镜患者70例纳入本研究,随机分为2组,每组35例。服药组胶囊内镜检查前口服促胃肠动力药莫沙比利10...目的探讨检查前口服莫沙比利对胶囊内镜检查中胃排空时间、小肠通过时间及胶囊排出时间的影响。方法将我院2007年3月-2008年5月间做胶囊内镜患者70例纳入本研究,随机分为2组,每组35例。服药组胶囊内镜检查前口服促胃肠动力药莫沙比利10mg,对照组则不服药物,记录胶囊内镜检查中的胃排空时间、小肠通过时间及胶囊排出时间。结果服药组平均胃排空时间和胶囊排出时间明显短于对照组(32min vs 51minP,<0.05),(35h vs 48hP,<0.05)。2组小肠通过时间(236min vs 268min)差异无统计学意义(P>0.05)。结论胶囊内镜检查前口服莫沙比利能缩短胃排空时间和胶囊排出体外的时间。展开更多
文摘AIM:To study the relative efficacy of cisapride, metoclopramide,domperidone,erythromycin and mosapride on gastric emptying(GE)and small intestinal transit(SIT) in morphine treated mice. METHODS:Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either sex.The groups included were control,morphine 1 mg/kg(s.c.15 rain before test meal)alone or with(45 rain before test meal p.o.)cisapride 10 mg/kg,metoclopramide 20 mg/kg, domperidone 20 mg/kg,erythromycin 6 mg/kg and mosapride 20 mg/kg. RESULTS:Cisapride,metoclopramide and mosapride were effective in enhancing gastric emptying significantly(P<0.001) whereas other prokinetic agents failed to do so in normal mice.Metoclopramide completely reversed morphine induced delay in gastric emptying followed by mosapride. Metoclopramide alone was effective when given to normal mice in increasing the SIT.Cisapride,though it did not show any significant effect on SIT in normal mice,was able to reverse morphine induced delay in SIT significantly(P<0.001) followed by metoclopramide and mosapride. CONCLUSION:Metoclopramide and cisapride are most effective in reversing morphine-induced delay in gastric emptying and small intestinal transit in mice respectively.
文摘目的探讨检查前口服莫沙比利对胶囊内镜检查中胃排空时间、小肠通过时间及胶囊排出时间的影响。方法将我院2007年3月-2008年5月间做胶囊内镜患者70例纳入本研究,随机分为2组,每组35例。服药组胶囊内镜检查前口服促胃肠动力药莫沙比利10mg,对照组则不服药物,记录胶囊内镜检查中的胃排空时间、小肠通过时间及胶囊排出时间。结果服药组平均胃排空时间和胶囊排出时间明显短于对照组(32min vs 51minP,<0.05),(35h vs 48hP,<0.05)。2组小肠通过时间(236min vs 268min)差异无统计学意义(P>0.05)。结论胶囊内镜检查前口服莫沙比利能缩短胃排空时间和胶囊排出体外的时间。
