Exosomes and long non-coding RNAs(lncRNAs)are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression.The discovery of lncRNAs in exosomes further indica...Exosomes and long non-coding RNAs(lncRNAs)are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression.The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance.In this review,we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research.These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.展开更多
Cancer remains a serious healthcare problem despite significant improvements in early detection and treatment approaches in the past few decades. Novel biomarkers for diagnosis and therapeutic strategies are urgently ...Cancer remains a serious healthcare problem despite significant improvements in early detection and treatment approaches in the past few decades. Novel biomarkers for diagnosis and therapeutic strategies are urgently needed. In recent years, long noncoding RNAs(lncRNAs) have been reported to be aberrantly expressed in tumors and show crosstalk with key cancer-related signaling pathways. In this review, we summarized the current progress of research on cytoplasmic lncRNAs and their roles in regulating cancer signaling and tumor progression, further characterization of which may lead to effective approaches for cancer prevention and therapy.展开更多
基金supported by the National Natural Science Foundation of China(Nos.81672791 and 81872300)the Foundation of the Department of Education of Zhejiang Province,China(No.Y201224954)+1 种基金the Zhejiang Provincial Natural Science Foundation of China(No.LY14H040007)the Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China(No.LR18C060002)
文摘Exosomes and long non-coding RNAs(lncRNAs)are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression.The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance.In this review,we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research.These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.
基金Project supported by the National Natural Science Foundation of China(Nos.81672791 and 81872300)the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China(No.LR18C060002)
文摘Cancer remains a serious healthcare problem despite significant improvements in early detection and treatment approaches in the past few decades. Novel biomarkers for diagnosis and therapeutic strategies are urgently needed. In recent years, long noncoding RNAs(lncRNAs) have been reported to be aberrantly expressed in tumors and show crosstalk with key cancer-related signaling pathways. In this review, we summarized the current progress of research on cytoplasmic lncRNAs and their roles in regulating cancer signaling and tumor progression, further characterization of which may lead to effective approaches for cancer prevention and therapy.
