Human intestinal capillariasis is a rare parasitosis that was first recognized in the Philippines in the 1960 s. Parasitosis is a life threatening disease and has been reported from Thailand, Japan, South of Taiwan (K...Human intestinal capillariasis is a rare parasitosis that was first recognized in the Philippines in the 1960 s. Parasitosis is a life threatening disease and has been reported from Thailand, Japan, South of Taiwan (Kaoh-Siung), Korea,Iran Egypt, Italy and Spain. Its clinical symptoms are characterized by chronic diarrhea, abdominal pain,borborygmus, marked weight loss, protein and electrolyte loss and cachexia. Capillariasis may be fatal if early treatment is not given. We reported 14 cases living in rural areas of Taiwan. Three cases had histories of travelling to Thailand. They might have been infected in Thailand while stayed there. Two cases had the diet of raw freshwater fish before. Three cases received emergency laparotomy due to peritonitis and two cases were found of enteritis cystica profunda. According to the route of transmission,freshwater and brackish-water fish may act as the intermediate host of the parasite. The most simple and convenient method of diagnosing capillariasis is stool examination. Two cases were diagnosed by histology. Mebendazole or albendezole 200 mg orally twice a day for 20-30 d is the treatment ef choice. All the patients were cured, and relapses were not obsetbed within 12 mo,展开更多
AIM： To analyze the hepatic and intestinal microcirculation in an animal model of liver cirrhosis and inflammatory bowel disease （IBD） and to characterize bhe anti-inflammatory action of antithrombin Ⅲ （ATⅢ） on...AIM： To analyze the hepatic and intestinal microcirculation in an animal model of liver cirrhosis and inflammatory bowel disease （IBD） and to characterize bhe anti-inflammatory action of antithrombin Ⅲ （ATⅢ） on leukocyte kinetics and liver damage. METHODS： Hepatic and intestinal microcirculation was investigated by intravital videomicroscopy. Standardized models of experimental chronic liver cirrhosis and bowel inflammation were employed. Animals were divided into four groups （n = 6/group）： controls, animals with cirrhosis, animals with cirrhosis and IBD, animals with cirrhosis and IBD treated with ATIII. RESULTS： Cirrhosis facilitated leukocyte rolling and sticking in hepatic sinusoids （1.91±0.28 sticker/μm vs 0.5±0.5 sticker/μm in controls, P〈0.05）. The effect enhanced in animals with cirrhosis and IBD （5.4±1.65 sticker/μm）, but reversed after ATIII application （3.97±1.04 sticker/μm, P〈0.05）. Mucosal blood flow showed no differences in cirrhotic animals and controls （5.3±0.31 nL/min vs5.4±0.25 nL/min） and was attenuated in animals wibh cirrhosis and IBD significantly （3.49±0.6 nL/min）. This effect was normalized in the treatment group （5.13±0.4 nL/min, P〈0.05）. Enzyme values rose during development of cirrhosis and bowel inflammation, and reduced after ATIII application （P〈0.05）. CONCLUSION： Liver cirrhosis in the presence of IBD leads to a significant reduction in mucosal blood flow and an increase in hepatic leukocyte adherence with consecutive liver injury, which can be prevented by administration of ATⅢ.展开更多
To elucidate the differences of the clinical course and treatments between intestinal Behcet's disease and Simple ulcer, we surveyed 17 patients with intestinal Behcet's disease and 4 patients with Simple ulce...To elucidate the differences of the clinical course and treatments between intestinal Behcet's disease and Simple ulcer, we surveyed 17 patients with intestinal Behcet's disease and 4 patients with Simple ulcer diagnosed from 1974 to 1997. There were no essential differences of clinical course between intestinal Behcet's disease and Simple ulcer. Regarding the treatments, 8 of 17 patients (47 per cent) with intestinal Behcet's disease were managed without surgical operation, whereas all patients with simple ulcer required operation. Treatments of intestinal Behcet's disease were based on corticosteroids,salazosulfapyridine,colchicine,indometha cin,and cyclosporin.展开更多
Increasing interest in theanalogues or antagonists inapplication of gut peptide the diagnosis and treatmentof colorectal cancer necessitates a better insight and characterization of receptors for gut peptides in the d...Increasing interest in theanalogues or antagonists inapplication of gut peptide the diagnosis and treatmentof colorectal cancer necessitates a better insight and characterization of receptors for gut peptides in the development and metastasis of colorectal cancer. This study visualized and characterized the receptors for vasoactive intestinal peptide, secretin and somatostatin in the development and metastasis of colorectal cancer with storage phosphor autoradiography. Receptors for these three peptides were demonstrated in tumor-free colon and colon tumors. A decrease in affinity of vasoactive intestinal peptide receptors was shown in the sequence from tumor-free colon (Kd=0.93nmol),展开更多
文摘Human intestinal capillariasis is a rare parasitosis that was first recognized in the Philippines in the 1960 s. Parasitosis is a life threatening disease and has been reported from Thailand, Japan, South of Taiwan (Kaoh-Siung), Korea,Iran Egypt, Italy and Spain. Its clinical symptoms are characterized by chronic diarrhea, abdominal pain,borborygmus, marked weight loss, protein and electrolyte loss and cachexia. Capillariasis may be fatal if early treatment is not given. We reported 14 cases living in rural areas of Taiwan. Three cases had histories of travelling to Thailand. They might have been infected in Thailand while stayed there. Two cases had the diet of raw freshwater fish before. Three cases received emergency laparotomy due to peritonitis and two cases were found of enteritis cystica profunda. According to the route of transmission,freshwater and brackish-water fish may act as the intermediate host of the parasite. The most simple and convenient method of diagnosing capillariasis is stool examination. Two cases were diagnosed by histology. Mebendazole or albendezole 200 mg orally twice a day for 20-30 d is the treatment ef choice. All the patients were cured, and relapses were not obsetbed within 12 mo,
文摘AIM： To analyze the hepatic and intestinal microcirculation in an animal model of liver cirrhosis and inflammatory bowel disease （IBD） and to characterize bhe anti-inflammatory action of antithrombin Ⅲ （ATⅢ） on leukocyte kinetics and liver damage. METHODS： Hepatic and intestinal microcirculation was investigated by intravital videomicroscopy. Standardized models of experimental chronic liver cirrhosis and bowel inflammation were employed. Animals were divided into four groups （n = 6/group）： controls, animals with cirrhosis, animals with cirrhosis and IBD, animals with cirrhosis and IBD treated with ATIII. RESULTS： Cirrhosis facilitated leukocyte rolling and sticking in hepatic sinusoids （1.91±0.28 sticker/μm vs 0.5±0.5 sticker/μm in controls, P〈0.05）. The effect enhanced in animals with cirrhosis and IBD （5.4±1.65 sticker/μm）, but reversed after ATIII application （3.97±1.04 sticker/μm, P〈0.05）. Mucosal blood flow showed no differences in cirrhotic animals and controls （5.3±0.31 nL/min vs5.4±0.25 nL/min） and was attenuated in animals wibh cirrhosis and IBD significantly （3.49±0.6 nL/min）. This effect was normalized in the treatment group （5.13±0.4 nL/min, P〈0.05）. Enzyme values rose during development of cirrhosis and bowel inflammation, and reduced after ATIII application （P〈0.05）. CONCLUSION： Liver cirrhosis in the presence of IBD leads to a significant reduction in mucosal blood flow and an increase in hepatic leukocyte adherence with consecutive liver injury, which can be prevented by administration of ATⅢ.
文摘To elucidate the differences of the clinical course and treatments between intestinal Behcet's disease and Simple ulcer, we surveyed 17 patients with intestinal Behcet's disease and 4 patients with Simple ulcer diagnosed from 1974 to 1997. There were no essential differences of clinical course between intestinal Behcet's disease and Simple ulcer. Regarding the treatments, 8 of 17 patients (47 per cent) with intestinal Behcet's disease were managed without surgical operation, whereas all patients with simple ulcer required operation. Treatments of intestinal Behcet's disease were based on corticosteroids,salazosulfapyridine,colchicine,indometha cin,and cyclosporin.
文摘Increasing interest in theanalogues or antagonists inapplication of gut peptide the diagnosis and treatmentof colorectal cancer necessitates a better insight and characterization of receptors for gut peptides in the development and metastasis of colorectal cancer. This study visualized and characterized the receptors for vasoactive intestinal peptide, secretin and somatostatin in the development and metastasis of colorectal cancer with storage phosphor autoradiography. Receptors for these three peptides were demonstrated in tumor-free colon and colon tumors. A decrease in affinity of vasoactive intestinal peptide receptors was shown in the sequence from tumor-free colon (Kd=0.93nmol),
