AIM:To compare intensity-modulated radiotherapy (IMRT) with conformal radiotherapy (CRT) by investigating the dose profiles of primary tumors,electively treated regions,and the doses to organs at risk. METHODS:CRT and...AIM:To compare intensity-modulated radiotherapy (IMRT) with conformal radiotherapy (CRT) by investigating the dose profiles of primary tumors,electively treated regions,and the doses to organs at risk. METHODS:CRT and IMRT plans were designed for five patients with upper esophageal carcinoma.For each patient, target volumes for primary lesions (67.2 Gy) and electively treated regions (50.4 Gy) were predefined.An experienced planner manually designed one CRT plan.Four IMRT plans were generated with the same dose-volume constraints,but with different beam arrangements.Indices including dose distributions,dose volume histograms (DVHs) and conformity index were compared. RESULTS:The plans with three intensity-modulated beams were discarded because the doses to spinal cord were lager than the tolerable dose 45Gy,and the dose on areas near the skin was up to 50Gy.When the number of intensity beams increased to five,IMRT plans were better than CRT plans in terms of the dose conformity and homogeneity of targets and the dose to OARs.The dose distributions changed little when the beam number increased from five to seven and nine. CONCLUSION:IMRT is superior to CRT for the treatment of upper esophageal carcinoma with simultaneous integrated boost (SIB).Five equispaced coplanar intensity-modulated beams can produce desirable dose distributions.The primary tumor can get higher equivalent dose by SIB technique. The SIB-IMRT technique shortens the total treatment time, and is an easier,more efficient,and perhaps a less error- prone way in delivering IMRT.展开更多
肝脏是结直肠癌血行转移最主要的靶器官,结直肠癌肝转移（colorectal cancer liver metastases）是结直肠癌治疗的重点和难点之一。约15%~25%结直肠癌病人在确诊时即合并有肝转移,另有15%~25%的病人将在行结直肠癌原发灶根治术后发生肝...肝脏是结直肠癌血行转移最主要的靶器官,结直肠癌肝转移（colorectal cancer liver metastases）是结直肠癌治疗的重点和难点之一。约15%~25%结直肠癌病人在确诊时即合并有肝转移,另有15%~25%的病人将在行结直肠癌原发灶根治术后发生肝转移,其中绝大多数（80%~90%）的肝转移灶无法获得根治性切除。展开更多
文摘AIM:To compare intensity-modulated radiotherapy (IMRT) with conformal radiotherapy (CRT) by investigating the dose profiles of primary tumors,electively treated regions,and the doses to organs at risk. METHODS:CRT and IMRT plans were designed for five patients with upper esophageal carcinoma.For each patient, target volumes for primary lesions (67.2 Gy) and electively treated regions (50.4 Gy) were predefined.An experienced planner manually designed one CRT plan.Four IMRT plans were generated with the same dose-volume constraints,but with different beam arrangements.Indices including dose distributions,dose volume histograms (DVHs) and conformity index were compared. RESULTS:The plans with three intensity-modulated beams were discarded because the doses to spinal cord were lager than the tolerable dose 45Gy,and the dose on areas near the skin was up to 50Gy.When the number of intensity beams increased to five,IMRT plans were better than CRT plans in terms of the dose conformity and homogeneity of targets and the dose to OARs.The dose distributions changed little when the beam number increased from five to seven and nine. CONCLUSION:IMRT is superior to CRT for the treatment of upper esophageal carcinoma with simultaneous integrated boost (SIB).Five equispaced coplanar intensity-modulated beams can produce desirable dose distributions.The primary tumor can get higher equivalent dose by SIB technique. The SIB-IMRT technique shortens the total treatment time, and is an easier,more efficient,and perhaps a less error- prone way in delivering IMRT.
文摘肝脏是结直肠癌血行转移最主要的靶器官,结直肠癌肝转移（colorectal cancer liver metastases）是结直肠癌治疗的重点和难点之一。约15%~25%结直肠癌病人在确诊时即合并有肝转移,另有15%~25%的病人将在行结直肠癌原发灶根治术后发生肝转移,其中绝大多数（80%~90%）的肝转移灶无法获得根治性切除。
