Purpose: Extra- gonadal germ cell tumors (GCTs) are rare and can be highly aggressive. If correctly identified and treated with multimodality chemotherapy, their prognosis can be significantly improved. We examined a ...Purpose: Extra- gonadal germ cell tumors (GCTs) are rare and can be highly aggressive. If correctly identified and treated with multimodality chemotherapy, their prognosis can be significantly improved. We examined a 10 month- old female with primary embryonal carcinoma of the orbit. Design: Case report and literature review. Methods: Case study with 7- year follow- up and literature review of intracranial and intraorbital GCT cases. Results: The patient presented with progressive proptosis and ophthalmoplegia. CT scan revealed an orbital apex mass and biopsy demonstrated a nongerminomatous GCT - an embryonal carcinoma. The patient is tumor- free 7 years after multimodality chemotherapy. She has mild amblyopia and a right micro esotropia. Conclusions: NongonadalGCTs of the orbit can occur and should be considered in the differential diagnosis of a young child with proptosis and ophthalmoplegia. Five- year survival rates improve significantly with accurate identification and treatment.展开更多
We report a case of a primary uterine choriocarcinoma associated with adenocarcinoma occurring during peri- menopausal age, and review the literature. The clinical course and the histopathology of the case were review...We report a case of a primary uterine choriocarcinoma associated with adenocarcinoma occurring during peri- menopausal age, and review the literature. The clinical course and the histopathology of the case were reviewed and a Medline literature search for other cases was performed. β HCG and analysis of uterine curettage provided the diagnosis of choriocarcinoma. Polychemotherapy, started immediately after the patient’ s clinical condition deteriorated, was successful. Colpohysterectomy and pelvic lymphadenectomy were performed 5 months later. Treatment was completed by vaginal curietherapy. Histhopathologic examination of the surgical specimen revealed only adenocarcinoma. The patient was followed for 18 months without evidence of recurrence. The literature search revealed that primary forms are exceptional; the etiology is unknown. Treatment is based on polychemotherapy. Primary choriocarcinomas are rare tumours, associated with other histopathological forms. We document a case occurring during the peri- menopausal period and review the literature on this pathology. The very poor prognosis in the past has changed with early polychemotherapy.展开更多
文摘Purpose: Extra- gonadal germ cell tumors (GCTs) are rare and can be highly aggressive. If correctly identified and treated with multimodality chemotherapy, their prognosis can be significantly improved. We examined a 10 month- old female with primary embryonal carcinoma of the orbit. Design: Case report and literature review. Methods: Case study with 7- year follow- up and literature review of intracranial and intraorbital GCT cases. Results: The patient presented with progressive proptosis and ophthalmoplegia. CT scan revealed an orbital apex mass and biopsy demonstrated a nongerminomatous GCT - an embryonal carcinoma. The patient is tumor- free 7 years after multimodality chemotherapy. She has mild amblyopia and a right micro esotropia. Conclusions: NongonadalGCTs of the orbit can occur and should be considered in the differential diagnosis of a young child with proptosis and ophthalmoplegia. Five- year survival rates improve significantly with accurate identification and treatment.
文摘We report a case of a primary uterine choriocarcinoma associated with adenocarcinoma occurring during peri- menopausal age, and review the literature. The clinical course and the histopathology of the case were reviewed and a Medline literature search for other cases was performed. β HCG and analysis of uterine curettage provided the diagnosis of choriocarcinoma. Polychemotherapy, started immediately after the patient’ s clinical condition deteriorated, was successful. Colpohysterectomy and pelvic lymphadenectomy were performed 5 months later. Treatment was completed by vaginal curietherapy. Histhopathologic examination of the surgical specimen revealed only adenocarcinoma. The patient was followed for 18 months without evidence of recurrence. The literature search revealed that primary forms are exceptional; the etiology is unknown. Treatment is based on polychemotherapy. Primary choriocarcinomas are rare tumours, associated with other histopathological forms. We document a case occurring during the peri- menopausal period and review the literature on this pathology. The very poor prognosis in the past has changed with early polychemotherapy.