多发性骨髓瘤（multiple myeloma,MM）是浆细胞恶性增殖性疾病,约占所有肿瘤的1%、血液系统肿瘤的13%,不可治愈,终将复发进展。随着新药如沙利度胺、来那度胺、硼替佐米等的问世,复发难治性多发性骨髓瘤（relapsed or refractory multip...多发性骨髓瘤（multiple myeloma,MM）是浆细胞恶性增殖性疾病,约占所有肿瘤的1%、血液系统肿瘤的13%,不可治愈,终将复发进展。随着新药如沙利度胺、来那度胺、硼替佐米等的问世,复发难治性多发性骨髓瘤（relapsed or refractory multiple myeloma,RRMM）患者的总生存率较前取得明显提高。然而,多数患者病情终会复发或者产生耐药。展开更多
The acetylation status of histones and non-histone proteins regulate chromatin remodeling and gene transcription. Histone deacetylase inhibitors (HDACi), a promising therapeutic approach to cancer, are characteristic ...The acetylation status of histones and non-histone proteins regulate chromatin remodeling and gene transcription. Histone deacetylase inhibitors (HDACi), a promising therapeutic approach to cancer, are characteristic of causing accumulation of acetylated histones and other transcriptional regulators. Recent studies demonstrate that HDACi is able to arrest the cell cycle in G1 and/or G2 phase, and to induce apoptosis in a variety form of transformed cells with little toxicity to normal cells. However, the exact antitumor mechanisms of HDACi are still unclear. This review provides an update on the current knowledge of HDACi with a focus on HDACi-regulated cell growth arrest and apoptosis.展开更多
文摘The acetylation status of histones and non-histone proteins regulate chromatin remodeling and gene transcription. Histone deacetylase inhibitors (HDACi), a promising therapeutic approach to cancer, are characteristic of causing accumulation of acetylated histones and other transcriptional regulators. Recent studies demonstrate that HDACi is able to arrest the cell cycle in G1 and/or G2 phase, and to induce apoptosis in a variety form of transformed cells with little toxicity to normal cells. However, the exact antitumor mechanisms of HDACi are still unclear. This review provides an update on the current knowledge of HDACi with a focus on HDACi-regulated cell growth arrest and apoptosis.
