Multicentric reticulohistiocytosis (MRH) is a rare histocytic disease characterized by destructive arthritis in association with classic skin findings. Although MRH is not strictly a paraneoplastic disease, one quarte...Multicentric reticulohistiocytosis (MRH) is a rare histocytic disease characterized by destructive arthritis in association with classic skin findings. Although MRH is not strictly a paraneoplastic disease, one quarter of cases are malignancy related. We report a case of MRH with an initial remission followed by an acute exacerbation several years later heralding the clinical presentation of endometrial carcinoma. During this flareup a skin biopsy specimen revealed a diffuse dermal infiltrate composed of histiocytes with ground-glass cytoplasm and multiple atypical mitoses. Approximately 40% of the cells stained with the proliferation marker Ki- 67. Treatment of endometrial carcinoma resulted in improvement of skin and joint symptoms, and a repeat biopsy specimen no longer demonstrated mitotic figures. These findings support a reactive and proliferative cause of MRH.展开更多
Rosai—Dorfman病（RDD）是一种原因不明、少见的良性组织细胞增生性疾病，主要特征是窦组织细胞增生伴淋巴结肿大，以及组织细胞胞质内有完整淋巴细胞的现象I】I。故又称窦性组织细胞增生伴巨大淋巴结病（sinus histiocytosis with mas...Rosai—Dorfman病（RDD）是一种原因不明、少见的良性组织细胞增生性疾病，主要特征是窦组织细胞增生伴淋巴结肿大，以及组织细胞胞质内有完整淋巴细胞的现象I】I。故又称窦性组织细胞增生伴巨大淋巴结病（sinus histiocytosis with massive lymphadenopathy，SHML）。展开更多
文摘Multicentric reticulohistiocytosis (MRH) is a rare histocytic disease characterized by destructive arthritis in association with classic skin findings. Although MRH is not strictly a paraneoplastic disease, one quarter of cases are malignancy related. We report a case of MRH with an initial remission followed by an acute exacerbation several years later heralding the clinical presentation of endometrial carcinoma. During this flareup a skin biopsy specimen revealed a diffuse dermal infiltrate composed of histiocytes with ground-glass cytoplasm and multiple atypical mitoses. Approximately 40% of the cells stained with the proliferation marker Ki- 67. Treatment of endometrial carcinoma resulted in improvement of skin and joint symptoms, and a repeat biopsy specimen no longer demonstrated mitotic figures. These findings support a reactive and proliferative cause of MRH.
文摘Rosai—Dorfman病（RDD）是一种原因不明、少见的良性组织细胞增生性疾病，主要特征是窦组织细胞增生伴淋巴结肿大，以及组织细胞胞质内有完整淋巴细胞的现象I】I。故又称窦性组织细胞增生伴巨大淋巴结病（sinus histiocytosis with massive lymphadenopathy，SHML）。
