Ketamine has been used in clinic as an intravenous anesthetic with little cardiovascular or respiratory depression for several decades.The major problem with ketamine is that it produces psychotomimetic effects that m...Ketamine has been used in clinic as an intravenous anesthetic with little cardiovascular or respiratory depression for several decades.The major problem with ketamine is that it produces psychotomimetic effects that may be associated with postoperative dysphoria.It has also been demonstrated that ketamine possesses analgesic properties in a subanesthetic doses.Small-dose ketamine in combination with sedative drugs has been used for sedation and analgesia with less toxicity than either drug alone.The purpose of this article is to review the clinical application of small-dose ketamine in induction of general anesthesia,short-term operation,and analgesia.展开更多
目的探索首发精神分裂症认知功能损害的特征,以及与精神症状的相关性。方法对30例首发精神分裂症患者,采用成套认知功能评估工具(the Cambridge Neuropsychological Test Automated Battery,CANTAB),评估记忆、注意功能、空间工作记忆...目的探索首发精神分裂症认知功能损害的特征,以及与精神症状的相关性。方法对30例首发精神分裂症患者,采用成套认知功能评估工具(the Cambridge Neuropsychological Test Automated Battery,CANTAB),评估记忆、注意功能、空间工作记忆及执行功能,采用阳性与阴性症状量表(the positive and negative syndromescale,PANSS)评估精神症状;并在治疗4周后再次评估认知功能和精神症状。同时,对30名正常对照进行认知功能测评。结果与对照组相比,患者组治疗前的持续注意、视觉记忆和空间工作记忆均较差(P<0.05),但执行功能无组间差异(P>0.05);治疗前,认知功能指标与PANSS各项因子无统计学相关性(P>0.05);治疗4周后,患者组认知功能水平与治疗前相比差异无统计学意义(P>0.05)。结论首发精神分裂症患者在发病初期即存在视觉记忆、持续注意及空间工作记忆受损,且独立于精神症状,在发病后的短时期内保持相对稳定。展开更多
文摘Ketamine has been used in clinic as an intravenous anesthetic with little cardiovascular or respiratory depression for several decades.The major problem with ketamine is that it produces psychotomimetic effects that may be associated with postoperative dysphoria.It has also been demonstrated that ketamine possesses analgesic properties in a subanesthetic doses.Small-dose ketamine in combination with sedative drugs has been used for sedation and analgesia with less toxicity than either drug alone.The purpose of this article is to review the clinical application of small-dose ketamine in induction of general anesthesia,short-term operation,and analgesia.
文摘目的探索首发精神分裂症认知功能损害的特征,以及与精神症状的相关性。方法对30例首发精神分裂症患者,采用成套认知功能评估工具(the Cambridge Neuropsychological Test Automated Battery,CANTAB),评估记忆、注意功能、空间工作记忆及执行功能,采用阳性与阴性症状量表(the positive and negative syndromescale,PANSS)评估精神症状;并在治疗4周后再次评估认知功能和精神症状。同时,对30名正常对照进行认知功能测评。结果与对照组相比,患者组治疗前的持续注意、视觉记忆和空间工作记忆均较差(P<0.05),但执行功能无组间差异(P>0.05);治疗前,认知功能指标与PANSS各项因子无统计学相关性(P>0.05);治疗4周后,患者组认知功能水平与治疗前相比差异无统计学意义(P>0.05)。结论首发精神分裂症患者在发病初期即存在视觉记忆、持续注意及空间工作记忆受损,且独立于精神症状,在发病后的短时期内保持相对稳定。
