AIM: To identify the prognostic factors with regard to survival for patients with brain metastasis from primary tumors of the gastrointestinal tract. METHODS: Nine hundred and sixteen patients with brain metastases, t...AIM: To identify the prognostic factors with regard to survival for patients with brain metastasis from primary tumors of the gastrointestinal tract. METHODS: Nine hundred and sixteen patients with brain metastases, treated with whole brain radiation therapy (WBRT) between January 1985 and December 2000 at the Department of Radiation Oncology, University Hospital Freiburg, were analyzed retrospectively. RESULTS: Fifty-seven patients presented with a primary tumor of the gastrointestinal tract (esophagus: n=0, stomach: n=10, colorectal: n=47). Twenty-six patients had a solitary brain metastasis, 31 patients presented with multiple brain metastases. Surgical resection was performed in 25 patients. WBRT was applied with daily fractions of 2 Gray (Gy) or 3Gy to a total dose of 50Gy or 30Gy, respectively. The interval between diagnoses of the primary tumors and brain metastases was 22.6mo vs 8.0mo for patients with primary tumors of the colon/rectum vs other primary tumors, respectively (P<0.01, log-rank). Median overall survival for all patients with brain metastases (n=916) was 3.4mo and 3.2mo for patients with gastrointestinal neoplasms. Patients with gastrointestinal primary tumors presented significantly more often with a solitary brain metastasis than patients with other primary tumors (P<0.05, log-rank). In patients with gastrointestinal neoplasms (n=57), the median overall survival was 5.8 mo for patients with solitary brain metastasis vs 2.7mo for patients with multiple brain metastases (P<0.01, log-rank). The median overall survival for patients with a Karnofsky performance status (KPS) ≥70 was 5.5mo vs 2.1mo for patients with KPS <70 (P<0.01, log-rank). At multivariate analysis (Cox Model) the performance status and the number of brain metastases were identified as independent prognostic factors for overall survival. CONCLUSION: Brain metastases occur late in the course of gastrointestinal tumors. Pretherapeutic variables like KPS and the number of brain metastases have a profound influence on treatment o展开更多
To detect the differences in the expression levels of protein and mRNA of E-cadherin and β-eatenin in primary tumor and lymph node metastatic tumor of nasopharyngeal carcinoma (NPC), and to investigate the mechanism ...To detect the differences in the expression levels of protein and mRNA of E-cadherin and β-eatenin in primary tumor and lymph node metastatic tumor of nasopharyngeal carcinoma (NPC), and to investigate the mechanism of invasion and metastasis of neoplastic cell in NPC. Methods: 21 biopsies taken from primary tumor and another 21 biopsies from lymph node metastatic tumor of NPC were collected from the affiliated hospitals of Sun Yat-sen University of Medical Sciences during 1999 2002. Western blotting assay, immunohistoehemieal staining and reverse transeriptase-polymeraes chain reaction (RT-PCR) were adopted to detect the expression levels of protein and mRNA of E-eadherin and β-eatenin in all of 42 samples. Results: (1) In 21 eases of lymph node metastatic tumor, the protein expression level of E-eadherin was lower detected by immunohistoehemieal staining (50% in average) and Western blotting (Rh 65±15.9 in average) than that in primary tumor of NPC (80% and 206.7+32.7 in average respectively). Furthermore, mRNA expression level of E-eadherin was also lower in metastatic tumor than that in primary tumor, with the difference being significant (P<0.05). (2) Both primary NPC and lymph node metastatic NPC were found to have high β-eatenin protein and mRNA expression with the differences being not statistically significant (P>0.05). (3) There was no correlation between neoplastic cell expression of β-eatenin and E-eadherin either in primary tumor or in lymph node metastatic tumors. Conclusion: Down-regulation of the expression of E-eadherin may play a critical role in neoplastic cell invasion and metastasis in NPC.展开更多
Purpose:To report ophthalmologic and angiographic features of choroidal metastases from carcinoid tumor and analyze their common clinical manifestation.Methods:Ophthalmologic examinations and fundus fluorescein angiog...Purpose:To report ophthalmologic and angiographic features of choroidal metastases from carcinoid tumor and analyze their common clinical manifestation.Methods:Ophthalmologic examinations and fundus fluorescein angiography(FFA) were performed in 30 patients suffered from carcinoid tumor,and four patients diagnosed of breast cancer(2 cases),lung cancer(1 case)and maxillary sinus cancer(1 case)were confirmed with choroidal metastases.Results:Choroidal metastases were found as the initial manifestations of the malignant tumors on 2 patients whose initial and chief complaints were decreasing vision,theirfun鄄dusl esions were mainly presented in the posterir pole and FFA showed high density of fluorescence of the lesions.Conclusions:This study indicated choroidal metastasis might be the first sign of metastases for patients with cancer.For patients with unknown metastastic cancers,examinations of the choroids may be useful for diagnosis and prognosis.Eye Science 2004;20:15-18.展开更多
HEDTMP (N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri(methylene phosphonic acid)) was labeled with 153Sm. The formation condition, stability, rabbit bone imaging and mouse bio-distribution of 153Sm -HEDTMP were investig...HEDTMP (N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri(methylene phosphonic acid)) was labeled with 153Sm. The formation condition, stability, rabbit bone imaging and mouse bio-distribution of 153Sm -HEDTMP were investigated. The results showed that weak basic media and high ligand’s concentration were favorable to form 153Sm-HEDTMP, and neutral or weak basic media increase the stability of 153Sm-HEDTMP. And the higher the con- centration of HEDTMP was, the more stable the labeling complex was. Bio-distribution study indicated the uptake of 153Sm-HEDTMP in skeleton was high ((25.68±1.22)ID%/g bone at 3 h post injection and (16.56±1.01)ID%/g bone at 48 h post injection), while the non-target tissue uptake and retention were relatively low, so 153Sm-HEDTMP is a promising bone tumor therapeutic agent.展开更多
文摘AIM: To identify the prognostic factors with regard to survival for patients with brain metastasis from primary tumors of the gastrointestinal tract. METHODS: Nine hundred and sixteen patients with brain metastases, treated with whole brain radiation therapy (WBRT) between January 1985 and December 2000 at the Department of Radiation Oncology, University Hospital Freiburg, were analyzed retrospectively. RESULTS: Fifty-seven patients presented with a primary tumor of the gastrointestinal tract (esophagus: n=0, stomach: n=10, colorectal: n=47). Twenty-six patients had a solitary brain metastasis, 31 patients presented with multiple brain metastases. Surgical resection was performed in 25 patients. WBRT was applied with daily fractions of 2 Gray (Gy) or 3Gy to a total dose of 50Gy or 30Gy, respectively. The interval between diagnoses of the primary tumors and brain metastases was 22.6mo vs 8.0mo for patients with primary tumors of the colon/rectum vs other primary tumors, respectively (P<0.01, log-rank). Median overall survival for all patients with brain metastases (n=916) was 3.4mo and 3.2mo for patients with gastrointestinal neoplasms. Patients with gastrointestinal primary tumors presented significantly more often with a solitary brain metastasis than patients with other primary tumors (P<0.05, log-rank). In patients with gastrointestinal neoplasms (n=57), the median overall survival was 5.8 mo for patients with solitary brain metastasis vs 2.7mo for patients with multiple brain metastases (P<0.01, log-rank). The median overall survival for patients with a Karnofsky performance status (KPS) ≥70 was 5.5mo vs 2.1mo for patients with KPS <70 (P<0.01, log-rank). At multivariate analysis (Cox Model) the performance status and the number of brain metastases were identified as independent prognostic factors for overall survival. CONCLUSION: Brain metastases occur late in the course of gastrointestinal tumors. Pretherapeutic variables like KPS and the number of brain metastases have a profound influence on treatment o
文摘To detect the differences in the expression levels of protein and mRNA of E-cadherin and β-eatenin in primary tumor and lymph node metastatic tumor of nasopharyngeal carcinoma (NPC), and to investigate the mechanism of invasion and metastasis of neoplastic cell in NPC. Methods: 21 biopsies taken from primary tumor and another 21 biopsies from lymph node metastatic tumor of NPC were collected from the affiliated hospitals of Sun Yat-sen University of Medical Sciences during 1999 2002. Western blotting assay, immunohistoehemieal staining and reverse transeriptase-polymeraes chain reaction (RT-PCR) were adopted to detect the expression levels of protein and mRNA of E-eadherin and β-eatenin in all of 42 samples. Results: (1) In 21 eases of lymph node metastatic tumor, the protein expression level of E-eadherin was lower detected by immunohistoehemieal staining (50% in average) and Western blotting (Rh 65±15.9 in average) than that in primary tumor of NPC (80% and 206.7+32.7 in average respectively). Furthermore, mRNA expression level of E-eadherin was also lower in metastatic tumor than that in primary tumor, with the difference being significant (P<0.05). (2) Both primary NPC and lymph node metastatic NPC were found to have high β-eatenin protein and mRNA expression with the differences being not statistically significant (P>0.05). (3) There was no correlation between neoplastic cell expression of β-eatenin and E-eadherin either in primary tumor or in lymph node metastatic tumors. Conclusion: Down-regulation of the expression of E-eadherin may play a critical role in neoplastic cell invasion and metastasis in NPC.
文摘Purpose:To report ophthalmologic and angiographic features of choroidal metastases from carcinoid tumor and analyze their common clinical manifestation.Methods:Ophthalmologic examinations and fundus fluorescein angiography(FFA) were performed in 30 patients suffered from carcinoid tumor,and four patients diagnosed of breast cancer(2 cases),lung cancer(1 case)and maxillary sinus cancer(1 case)were confirmed with choroidal metastases.Results:Choroidal metastases were found as the initial manifestations of the malignant tumors on 2 patients whose initial and chief complaints were decreasing vision,theirfun鄄dusl esions were mainly presented in the posterir pole and FFA showed high density of fluorescence of the lesions.Conclusions:This study indicated choroidal metastasis might be the first sign of metastases for patients with cancer.For patients with unknown metastastic cancers,examinations of the choroids may be useful for diagnosis and prognosis.Eye Science 2004;20:15-18.
文摘HEDTMP (N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri(methylene phosphonic acid)) was labeled with 153Sm. The formation condition, stability, rabbit bone imaging and mouse bio-distribution of 153Sm -HEDTMP were investigated. The results showed that weak basic media and high ligand’s concentration were favorable to form 153Sm-HEDTMP, and neutral or weak basic media increase the stability of 153Sm-HEDTMP. And the higher the con- centration of HEDTMP was, the more stable the labeling complex was. Bio-distribution study indicated the uptake of 153Sm-HEDTMP in skeleton was high ((25.68±1.22)ID%/g bone at 3 h post injection and (16.56±1.01)ID%/g bone at 48 h post injection), while the non-target tissue uptake and retention were relatively low, so 153Sm-HEDTMP is a promising bone tumor therapeutic agent.
