目的:分析先天性肠闭锁的病理组织学改变及其对肠道功能的影响,以探讨肠闭锁手术的切除范围。方法:对16例先天性肠闭锁手术切除之远近端肠管行 HE 染色,光镜下观察肠壁各层厚度及神经组织的改变及其范围。结果:在各型肠闭锁中,远近端肠...目的:分析先天性肠闭锁的病理组织学改变及其对肠道功能的影响,以探讨肠闭锁手术的切除范围。方法:对16例先天性肠闭锁手术切除之远近端肠管行 HE 染色,光镜下观察肠壁各层厚度及神经组织的改变及其范围。结果:在各型肠闭锁中,远近端肠管除肠壁厚度有改变外,各层神经丛及神经节细胞数均较正常明显减少,近端改变范围大于10cm,远端改变局限于2cm 内。在此范围内,随着远离闭锁盲端,上述指标均有逐渐增加的趋势。结论:本组结果从病理角度上对肠闭锁手术切除范围提供了理论依据,并对术后肠道功能恢复缓慢的现象给予解释。提出肠闭锁术后应依据具体情况合理延长 TPN 时间,以期患儿安全度过肠道功能自我逆转期。展开更多
The changes in retinal thickness and visual function in type 2 diabetic patients without clinical evidence of diabetic retinopathy were evaluated. A total of 141 diabetic subjects without retinopathy and 158 healthy s...The changes in retinal thickness and visual function in type 2 diabetic patients without clinical evidence of diabetic retinopathy were evaluated. A total of 141 diabetic subjects without retinopathy and 158 healthy subjects were enrolled in this study. Superior macular ganglion cell complex thicknesses were significantly decreased in diabetic cases, and no significant peripapillary retinal nerve fiber layer thickness changes were observed. The contrast sensitivities at all space frequencies were significantly different between diabetic patients and controls. The mean P50 amplitude from pattern electroretinogram results was reduced significantly in the diabetic group. In the diabetic group, average superior ganglion cell complex thicknesses positively correlated with both contrast sensitivities at high spatial frequencies and P50 amplitudes. The results indicated that ganglion cell complex thickness and visual function changes could be observed in diabetic subjects before the onset of any significant diabetic retinopathy. Macular ganglion cell complex reduction occurred much earlier than peripapillary retinal nerve fiber layer thinning in diabetic patients without retinopathy.展开更多
基金supported by the National Natural Science Foundation of China(81341029)
文摘The changes in retinal thickness and visual function in type 2 diabetic patients without clinical evidence of diabetic retinopathy were evaluated. A total of 141 diabetic subjects without retinopathy and 158 healthy subjects were enrolled in this study. Superior macular ganglion cell complex thicknesses were significantly decreased in diabetic cases, and no significant peripapillary retinal nerve fiber layer thickness changes were observed. The contrast sensitivities at all space frequencies were significantly different between diabetic patients and controls. The mean P50 amplitude from pattern electroretinogram results was reduced significantly in the diabetic group. In the diabetic group, average superior ganglion cell complex thicknesses positively correlated with both contrast sensitivities at high spatial frequencies and P50 amplitudes. The results indicated that ganglion cell complex thickness and visual function changes could be observed in diabetic subjects before the onset of any significant diabetic retinopathy. Macular ganglion cell complex reduction occurred much earlier than peripapillary retinal nerve fiber layer thinning in diabetic patients without retinopathy.
