To investigate the effects of Ginse noside Rb 1 on the proliferation of Schwann cells in culture.Methods: Applying MTT assay and Thymidine incorporation assay, the effects of Ginsenoside Rb 1 on the proliferation of S...To investigate the effects of Ginse noside Rb 1 on the proliferation of Schwann cells in culture.Methods: Applying MTT assay and Thymidine incorporation assay, the effects of Ginsenoside Rb 1 on the proliferation of Schwann cells isolated from the sciatic nerve of adult rat were studied.Results: Ginsenoside Rb 1 (10 μg/ml) significantly induced Sc hwann cell proliferation, the effect was similar to NGF (50 μg/ml). At high con centrations of Ginsenoside Rb 1 (1 mg/ml), the proliferation of Schwann cells w as significantly inhibited. Conclusions: Ginsenoside Rb 1 at the optimal concentrations is found to be effective in inducing the proliferation of Schwann cells, but at hi gher concentrations the drug is cytotoxic for Schwann cells.展开更多
文摘To investigate the effects of Ginse noside Rb 1 on the proliferation of Schwann cells in culture.Methods: Applying MTT assay and Thymidine incorporation assay, the effects of Ginsenoside Rb 1 on the proliferation of Schwann cells isolated from the sciatic nerve of adult rat were studied.Results: Ginsenoside Rb 1 (10 μg/ml) significantly induced Sc hwann cell proliferation, the effect was similar to NGF (50 μg/ml). At high con centrations of Ginsenoside Rb 1 (1 mg/ml), the proliferation of Schwann cells w as significantly inhibited. Conclusions: Ginsenoside Rb 1 at the optimal concentrations is found to be effective in inducing the proliferation of Schwann cells, but at hi gher concentrations the drug is cytotoxic for Schwann cells.
