AIM: To investigate the effect of Ginkgo biloba extract on the enteric neurons in the small intestine of diabetic rats. METHODS: Fifteen Wistar rats were divided into three groups: control group (C), diabetic group (D...AIM: To investigate the effect of Ginkgo biloba extract on the enteric neurons in the small intestine of diabetic rats. METHODS: Fifteen Wistar rats were divided into three groups: control group (C), diabetic group (D) and diabetic-treated (DT) daily with EGb 761 extract (50 mg/kg body weight) for 120 d. The enteric neurons were identified by the myosin-V immunohistochemical technique. The neuronal density and the cell body area were also analyzed. RESULTS: There was a significant decrease in the neuronal population (myenteric plexus P = 0.0351; submucous plexus P = 0.0217) in both plexuses of the jejunum in group D when compared to group C. With regard to the ileum, there was a significant decrease (P = 0.0117) only in the myenteric plexus. The DT group showed preservation of the neuronal population in the jejunum submucous plexus and in the myenteric plexus in the ileum. The cell body area in group D increased significantly (P = 0.0001) in the myenteric plexus of both segments studied as well as in the ileum submucosal plexus, when compared to C. The treatment reduced (P = 0.0001) the cell body area of the submucosal neurons of both segments and the jejunum myenteric neurons. CONCLUSION: The purified Ginkgo biloba extract has a neuroprotective effect on the jejunum submucous plexus and the myenteric plexus of the ileum of diabetic rats.展开更多
In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,w...In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,we have found that the phase of a neuronal oscillator undergoes periodic evolution or locked state,which is determined by the synaptic time constant.The synaptic time constant is also an important condition under which the global network is synchronized.When the synaptic time constant is relatively small,perfectly synchronized behavior quickly occurs in the neuronal population.As the synaptic time constant becomes slightly larger,periodic synchronization emerges in the neuronal population.However,synchronized activity in the neuronal population is lost for larger synaptic time constant.The external periodic stimulus can change the synchronization patterns in the neuronal population.With a weak low-frequency stimulus,the neuronal populations quick synchronized bursting;whereas a high-frequency stimulus can produce synchronized overlapping bursting.We have also found that neuronal oscillators with type-II phase response curves are more susceptible to synchronization than those with type-I phase response curves.展开更多
文摘AIM: To investigate the effect of Ginkgo biloba extract on the enteric neurons in the small intestine of diabetic rats. METHODS: Fifteen Wistar rats were divided into three groups: control group (C), diabetic group (D) and diabetic-treated (DT) daily with EGb 761 extract (50 mg/kg body weight) for 120 d. The enteric neurons were identified by the myosin-V immunohistochemical technique. The neuronal density and the cell body area were also analyzed. RESULTS: There was a significant decrease in the neuronal population (myenteric plexus P = 0.0351; submucous plexus P = 0.0217) in both plexuses of the jejunum in group D when compared to group C. With regard to the ileum, there was a significant decrease (P = 0.0117) only in the myenteric plexus. The DT group showed preservation of the neuronal population in the jejunum submucous plexus and in the myenteric plexus in the ileum. The cell body area in group D increased significantly (P = 0.0001) in the myenteric plexus of both segments studied as well as in the ileum submucosal plexus, when compared to C. The treatment reduced (P = 0.0001) the cell body area of the submucosal neurons of both segments and the jejunum myenteric neurons. CONCLUSION: The purified Ginkgo biloba extract has a neuroprotective effect on the jejunum submucous plexus and the myenteric plexus of the ileum of diabetic rats.
基金supported by the National Natural Science Foundation of China(Grant Nos.1123200511172086)
文摘In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,we have found that the phase of a neuronal oscillator undergoes periodic evolution or locked state,which is determined by the synaptic time constant.The synaptic time constant is also an important condition under which the global network is synchronized.When the synaptic time constant is relatively small,perfectly synchronized behavior quickly occurs in the neuronal population.As the synaptic time constant becomes slightly larger,periodic synchronization emerges in the neuronal population.However,synchronized activity in the neuronal population is lost for larger synaptic time constant.The external periodic stimulus can change the synchronization patterns in the neuronal population.With a weak low-frequency stimulus,the neuronal populations quick synchronized bursting;whereas a high-frequency stimulus can produce synchronized overlapping bursting.We have also found that neuronal oscillators with type-II phase response curves are more susceptible to synchronization than those with type-I phase response curves.
