目的应用磁化转移成像技术(Magnetization Transfer Imaging,MTI)研究视神经脊髓炎(Neuromyelitis Optica,NMO)患者早期脑组织是否存在隐匿性改变。方法收集27例临床确诊为NMO患者的临床资料(包括病程、年龄、主要临床症状、EDSS评分)...目的应用磁化转移成像技术(Magnetization Transfer Imaging,MTI)研究视神经脊髓炎(Neuromyelitis Optica,NMO)患者早期脑组织是否存在隐匿性改变。方法收集27例临床确诊为NMO患者的临床资料(包括病程、年龄、主要临床症状、EDSS评分)。采用3.0T磁共振技术对27例NMO患者进行头部MTI扫描,同时对30例年龄、性别相匹配的正常自愿者进行相同序列的扫描。对患者的灰白质感兴趣区(包括双侧岛叶、双侧尾状核、双侧豆状核、双侧苍白球、双侧丘脑、双侧扣带回)和白质感兴趣区(包括胼胝体膝部、胼胝体压部、双侧大脑脚、双侧内囊后肢、双侧放射冠后部)进行分析。结果急性期NMO组右侧豆状核、双侧苍白球、双侧扣带回的磁化传递率(MTR)值较正常健康对照组的MTR值升高。稳定期NMO组右侧尾状核、双侧苍白球、双侧扣带回的MTR值较正常健康对照组的MTR值降低。急性期NMO组双侧大脑脚的MTR值较健康对照组降低。其余的感兴趣区灰白质部位与健康对照组MTR比较差异无统计学意义(P>0.05)。结论 NMO患者大脑灰白质磁化转移成像扫描显示MTR存在差异提示可能存在隐匿性损伤,这种隐匿性改变在急性期与稳定期可能存在差异。展开更多
目的探究无创诊断对儿童颅内动静脉畸形(AVM)隐匿性病变的及时精准诊断及评估价值.方法选取2017年1月至2018年12月河北省儿童医院65例疑似AVM患儿为观察组,均行MRI及3D-TOF-MT-MRA检查,比较两种检查方法图像质量、信噪比(SNR)、对比度...目的探究无创诊断对儿童颅内动静脉畸形(AVM)隐匿性病变的及时精准诊断及评估价值.方法选取2017年1月至2018年12月河北省儿童医院65例疑似AVM患儿为观察组,均行MRI及3D-TOF-MT-MRA检查,比较两种检查方法图像质量、信噪比(SNR)、对比度噪声比(CNR),以数字减影血管造影(DSA)检查结果为"金标准",比较MRI、3D-TOF-MT-MRA单独及联合诊断儿童AVM的价值及评估Spetzler-Martin分级的准确性,另选取本院收治的65例AVM患儿为对照组,两组均根据术前影像学检查结果制定手术治疗方案,比较两组手术前后生活质量(PedsQLTM4.0评分)、预后情况(改良Rankin评分),随访3年,统计比较两组并发症发生率和死亡率.结果3D-TOF-MT-MRA检查的图像质量、SNR、CNR均高于MRI检查(P<0.05);MRI、3D-TOF-MT-MRA诊断儿童AVM的曲线下面积(area under the curve,AUC)分别为0.864、0.883,二者联合诊断的AUC最大,为0.939,联合诊断的敏感度、特异度、准确度分别为97.78%、90.00%、95.38%;MRI联合3D-TOF-MT-MRA评估Spetzler-Martin分级的准确度(97.78%)高于MRI单独评估(80.00%)(P<0.05),但与3D-TOF-MT-MRA单独评估的准确度(88.89%)比较,差异无统计学意义(P>0.05);两组术后PedsQLTM4.0评分均高于术前,且观察组高于对照组,mRS评分均低于术前,且观察组低于对照组(P<0.05);观察组并发症总发生率、死亡率(6.82%、4.55%)均低于对照组(22.22%、17.46%)(P<0.05).结论3D-TOF-MT-MRA联合MRI诊断儿童AVM能有效提高诊断敏感度及准确度,且在评估Spetzler-Martin分级方面具有较高可靠性,有助于及时精准判定儿童AVM病情,指导临床制定最佳治疗方法,从而改善患儿预后.展开更多
传统MRI显示的脊髓信号变化与脊髓型颈椎病(cervical spondylotic myelopathy,CSM)的临床表现有明显的相关性,磁化转移比(magnetization transfer ratio,MTR)可以反映髓鞘的完整性和患者的严重程度,神经元定向弥散和密度成像(neurite or...传统MRI显示的脊髓信号变化与脊髓型颈椎病(cervical spondylotic myelopathy,CSM)的临床表现有明显的相关性,磁化转移比(magnetization transfer ratio,MTR)可以反映髓鞘的完整性和患者的严重程度,神经元定向弥散和密度成像(neurite orientation dispersion and density imaging,NODDI)能够更好地了解脊髓微观结构信息和预测患者的术后恢复,而动态MRI(dynamic MRI,dMRI)可以更准确地确定颈椎病患者的病理狭窄或压迫。对近年来磁共振成像技术在脊髓型颈椎病患者诊治方面的应用进行了综述。展开更多
Objective: To study whole-brain MR measures derived from diffusion tensor i maging and magnetization transfer imaging(MTI) for the in vivo assessment of cum ulative neuropathologic changes in HIV and to evaluate the q...Objective: To study whole-brain MR measures derived from diffusion tensor i maging and magnetization transfer imaging(MTI) for the in vivo assessment of cum ulative neuropathologic changes in HIV and to evaluate the quantitative imaging strategies with respect to cognitive status measures including the severity of d ementia and the degree of impairment in specific cognitive domains including att ention, memory, constructional abilities, and motor speed. Methods: Quantitative whole-brain measurements, including fractional anisotropy (FA), apparent diff usion coefficient (ADC), and magnetization transfer ratio (MTR), were derived fr om histograms and compared in HIV and control participants. Relationships betwee n the MR and cognitive status measures were examined. Results: Wholebrain FA and MTR were reduced in patients with HIV and correlated with dementia severity. Wh ole-brain MTR and ADC were correlated with psychomotor deficits. Evaluation of relationships between the studied MR measures indicated a correlation between A DC and MTR; FA was not correlated with either ADC or MTR. Conclusions: Findings from this investigation support the use of quantitative whole-brain MR measure s for evaluation of disease burden in HIV. Reductions in whole-brain fractiona l anisotropy and magnetization transfer ratio (MTR) distinguished HIV and contro l subjects, and these measures were associated with dementia severity. Relations hips were identified between whole-brain MTR and apparent diffusion coefficien t and psychomotor deficits. Combining these quantitative strategies in neuroimag ing examinations may provide more comprehensive information concerning ongoing c hanges in the brains of HIV patients.展开更多
文摘目的应用磁化转移成像技术(Magnetization Transfer Imaging,MTI)研究视神经脊髓炎(Neuromyelitis Optica,NMO)患者早期脑组织是否存在隐匿性改变。方法收集27例临床确诊为NMO患者的临床资料(包括病程、年龄、主要临床症状、EDSS评分)。采用3.0T磁共振技术对27例NMO患者进行头部MTI扫描,同时对30例年龄、性别相匹配的正常自愿者进行相同序列的扫描。对患者的灰白质感兴趣区(包括双侧岛叶、双侧尾状核、双侧豆状核、双侧苍白球、双侧丘脑、双侧扣带回)和白质感兴趣区(包括胼胝体膝部、胼胝体压部、双侧大脑脚、双侧内囊后肢、双侧放射冠后部)进行分析。结果急性期NMO组右侧豆状核、双侧苍白球、双侧扣带回的磁化传递率(MTR)值较正常健康对照组的MTR值升高。稳定期NMO组右侧尾状核、双侧苍白球、双侧扣带回的MTR值较正常健康对照组的MTR值降低。急性期NMO组双侧大脑脚的MTR值较健康对照组降低。其余的感兴趣区灰白质部位与健康对照组MTR比较差异无统计学意义(P>0.05)。结论 NMO患者大脑灰白质磁化转移成像扫描显示MTR存在差异提示可能存在隐匿性损伤,这种隐匿性改变在急性期与稳定期可能存在差异。
文摘目的探究无创诊断对儿童颅内动静脉畸形(AVM)隐匿性病变的及时精准诊断及评估价值.方法选取2017年1月至2018年12月河北省儿童医院65例疑似AVM患儿为观察组,均行MRI及3D-TOF-MT-MRA检查,比较两种检查方法图像质量、信噪比(SNR)、对比度噪声比(CNR),以数字减影血管造影(DSA)检查结果为"金标准",比较MRI、3D-TOF-MT-MRA单独及联合诊断儿童AVM的价值及评估Spetzler-Martin分级的准确性,另选取本院收治的65例AVM患儿为对照组,两组均根据术前影像学检查结果制定手术治疗方案,比较两组手术前后生活质量(PedsQLTM4.0评分)、预后情况(改良Rankin评分),随访3年,统计比较两组并发症发生率和死亡率.结果3D-TOF-MT-MRA检查的图像质量、SNR、CNR均高于MRI检查(P<0.05);MRI、3D-TOF-MT-MRA诊断儿童AVM的曲线下面积(area under the curve,AUC)分别为0.864、0.883,二者联合诊断的AUC最大,为0.939,联合诊断的敏感度、特异度、准确度分别为97.78%、90.00%、95.38%;MRI联合3D-TOF-MT-MRA评估Spetzler-Martin分级的准确度(97.78%)高于MRI单独评估(80.00%)(P<0.05),但与3D-TOF-MT-MRA单独评估的准确度(88.89%)比较,差异无统计学意义(P>0.05);两组术后PedsQLTM4.0评分均高于术前,且观察组高于对照组,mRS评分均低于术前,且观察组低于对照组(P<0.05);观察组并发症总发生率、死亡率(6.82%、4.55%)均低于对照组(22.22%、17.46%)(P<0.05).结论3D-TOF-MT-MRA联合MRI诊断儿童AVM能有效提高诊断敏感度及准确度,且在评估Spetzler-Martin分级方面具有较高可靠性,有助于及时精准判定儿童AVM病情,指导临床制定最佳治疗方法,从而改善患儿预后.
文摘传统MRI显示的脊髓信号变化与脊髓型颈椎病(cervical spondylotic myelopathy,CSM)的临床表现有明显的相关性,磁化转移比(magnetization transfer ratio,MTR)可以反映髓鞘的完整性和患者的严重程度,神经元定向弥散和密度成像(neurite orientation dispersion and density imaging,NODDI)能够更好地了解脊髓微观结构信息和预测患者的术后恢复,而动态MRI(dynamic MRI,dMRI)可以更准确地确定颈椎病患者的病理狭窄或压迫。对近年来磁共振成像技术在脊髓型颈椎病患者诊治方面的应用进行了综述。
文摘Objective: To study whole-brain MR measures derived from diffusion tensor i maging and magnetization transfer imaging(MTI) for the in vivo assessment of cum ulative neuropathologic changes in HIV and to evaluate the quantitative imaging strategies with respect to cognitive status measures including the severity of d ementia and the degree of impairment in specific cognitive domains including att ention, memory, constructional abilities, and motor speed. Methods: Quantitative whole-brain measurements, including fractional anisotropy (FA), apparent diff usion coefficient (ADC), and magnetization transfer ratio (MTR), were derived fr om histograms and compared in HIV and control participants. Relationships betwee n the MR and cognitive status measures were examined. Results: Wholebrain FA and MTR were reduced in patients with HIV and correlated with dementia severity. Wh ole-brain MTR and ADC were correlated with psychomotor deficits. Evaluation of relationships between the studied MR measures indicated a correlation between A DC and MTR; FA was not correlated with either ADC or MTR. Conclusions: Findings from this investigation support the use of quantitative whole-brain MR measure s for evaluation of disease burden in HIV. Reductions in whole-brain fractiona l anisotropy and magnetization transfer ratio (MTR) distinguished HIV and contro l subjects, and these measures were associated with dementia severity. Relations hips were identified between whole-brain MTR and apparent diffusion coefficien t and psychomotor deficits. Combining these quantitative strategies in neuroimag ing examinations may provide more comprehensive information concerning ongoing c hanges in the brains of HIV patients.
