Solid lipid microparticles of erythromycin ethyl succinate were prepared using solvent evaporation method to improve its bioavailability and efficacy. The solvent was allowed to evaporate after which the various entra...Solid lipid microparticles of erythromycin ethyl succinate were prepared using solvent evaporation method to improve its bioavailability and efficacy. The solvent was allowed to evaporate after which the various entrapments were determined; the best entrapment was used in the in vivo studies to determine the bioavailability and efficacy. This study was done with albino mice. The best entrapment obtained was 83% with a loading capacity of 2.9% （Batch D） and was used in comparison with the unformulated drug to check for the in vivo efficacy. The results show higher efficacy with the formulated drug than with the pure drug both in vitro and in vivo. The in vitro test results were better despite that some enzymes which need to act on the solid lipid microparticles were not present in the in vitro assay and could lead to a reduction in the release of the drugs. In conclusion, there was improvement in efficacy, and hence bioavailability.展开更多
A composite of 60% of lanthanum stearate and 40%（mass fraction） of stearic acid was prepared and its influence on the crystallization characteristics of isotatic polypropylene （iPP） was investigated. The results s...A composite of 60% of lanthanum stearate and 40%（mass fraction） of stearic acid was prepared and its influence on the crystallization characteristics of isotatic polypropylene （iPP） was investigated. The results showed that we had found a new kind of β-crystalline form nucleating agent. The composite might induced rather high proportion of β-modification. The relative content of β-phase estimated by WAXD and DSC was 30% and 51.8% in a PP containing 2.5%（mass fraction） of the composite respectively. The isothermal crystallization at 130 ℃ and melting behavior examined by DSC revealed that the composite accelerated the overall rate of crystallization remarkably. The half crystallization period t1/2 decreased from 11 8 min of pure PP to 7 5 min of PP containing 2.5% of the composite. However, the composite had no obvious influence on crystallization mode and the size of α-crystal unit cell.展开更多
文摘Solid lipid microparticles of erythromycin ethyl succinate were prepared using solvent evaporation method to improve its bioavailability and efficacy. The solvent was allowed to evaporate after which the various entrapments were determined; the best entrapment was used in the in vivo studies to determine the bioavailability and efficacy. This study was done with albino mice. The best entrapment obtained was 83% with a loading capacity of 2.9% （Batch D） and was used in comparison with the unformulated drug to check for the in vivo efficacy. The results show higher efficacy with the formulated drug than with the pure drug both in vitro and in vivo. The in vitro test results were better despite that some enzymes which need to act on the solid lipid microparticles were not present in the in vitro assay and could lead to a reduction in the release of the drugs. In conclusion, there was improvement in efficacy, and hence bioavailability.
文摘A composite of 60% of lanthanum stearate and 40%（mass fraction） of stearic acid was prepared and its influence on the crystallization characteristics of isotatic polypropylene （iPP） was investigated. The results showed that we had found a new kind of β-crystalline form nucleating agent. The composite might induced rather high proportion of β-modification. The relative content of β-phase estimated by WAXD and DSC was 30% and 51.8% in a PP containing 2.5%（mass fraction） of the composite respectively. The isothermal crystallization at 130 ℃ and melting behavior examined by DSC revealed that the composite accelerated the overall rate of crystallization remarkably. The half crystallization period t1/2 decreased from 11 8 min of pure PP to 7 5 min of PP containing 2.5% of the composite. However, the composite had no obvious influence on crystallization mode and the size of α-crystal unit cell.
