The experimental pathological studies of silicone rubber vaginal contraceptive ring with megestrol acetate on nineteen mature female Fujian Rhesus monkeys were performed.The experimental monkeys were divided into thre...The experimental pathological studies of silicone rubber vaginal contraceptive ring with megestrol acetate on nineteen mature female Fujian Rhesus monkeys were performed.The experimental monkeys were divided into three groups: high-dose,low-does and control groups.The results showed that ovulation could be inhibited in the high-dose group.There was no significant suppression o/f ovulation or only slight suppression in the low-dose group,but with disturbance of the function of corpus luteum.The endometria were all atrophic in all treated groups,this phenomenon might be the main mechanism of antifertilitic action of the device containing the drug.There was no obvious toxic effect and tumor formation in the various internal organs of all 3 groups.The result indicated that silicone rubber vaginal ring containing suitable dose of megestrol acetate might be a satisfactory and effective method for contraception.展开更多
文摘The experimental pathological studies of silicone rubber vaginal contraceptive ring with megestrol acetate on nineteen mature female Fujian Rhesus monkeys were performed.The experimental monkeys were divided into three groups: high-dose,low-does and control groups.The results showed that ovulation could be inhibited in the high-dose group.There was no significant suppression o/f ovulation or only slight suppression in the low-dose group,but with disturbance of the function of corpus luteum.The endometria were all atrophic in all treated groups,this phenomenon might be the main mechanism of antifertilitic action of the device containing the drug.There was no obvious toxic effect and tumor formation in the various internal organs of all 3 groups.The result indicated that silicone rubber vaginal ring containing suitable dose of megestrol acetate might be a satisfactory and effective method for contraception.
