Introduction. We report a cutaneous ulceration which occurred following a BCG revaccination. Observation. A 17 year old man, without previous history, presented a large and slow progressive ulceration of the left delt...Introduction. We report a cutaneous ulceration which occurred following a BCG revaccination. Observation. A 17 year old man, without previous history, presented a large and slow progressive ulceration of the left deltoid area following a fortuitous BCG revaccination. He did not complain of any other symptom. The swab culture from the exudate isolated Mycobacterium boviswhereasthedirectanalysisbyZiehlstainingwasnegative. The ulceration healed in four months with local and systemic treatment with isoniazid. Discussion. BCG vaccination side effects are largely described and can be either nonspecific, like with all vaccinations, or specific and due to the infection with Mycobacterium bovis. It can behave like an infectious agent or an immunogenic agent. The BCG revaccination complications are much less known because there are only few publications in the literature. In our case, the mechanism may have been infectious or imply immune reaction with Arthus’type-phenomenon and/or a type IV hypersensitivity. Conclusion. Adverse reactions due to revaccination are rarely described should became lessfrequentwhentheBCGrevaccinationisabandonedfollowing the decision of French regulatory authorities. Nevertheless, such complications can occur by accident, as the case in our patient.展开更多
自从1976年 Nime 等首次报告人隐孢子虫肠炎以来,引起了世界各国医学界的普遍重视.目前,亚、非、欧、拉美洲许多国家已有不少研究证明,隐孢子虫是人类,尤其是小儿腹泻的重要病原之一.但国内报道甚少.本文是对呼和浩特地区腹泻患儿粪便...自从1976年 Nime 等首次报告人隐孢子虫肠炎以来,引起了世界各国医学界的普遍重视.目前,亚、非、欧、拉美洲许多国家已有不少研究证明,隐孢子虫是人类,尤其是小儿腹泻的重要病原之一.但国内报道甚少.本文是对呼和浩特地区腹泻患儿粪便进行了检查的结果.1 对象和方法1.1展开更多
文摘Introduction. We report a cutaneous ulceration which occurred following a BCG revaccination. Observation. A 17 year old man, without previous history, presented a large and slow progressive ulceration of the left deltoid area following a fortuitous BCG revaccination. He did not complain of any other symptom. The swab culture from the exudate isolated Mycobacterium boviswhereasthedirectanalysisbyZiehlstainingwasnegative. The ulceration healed in four months with local and systemic treatment with isoniazid. Discussion. BCG vaccination side effects are largely described and can be either nonspecific, like with all vaccinations, or specific and due to the infection with Mycobacterium bovis. It can behave like an infectious agent or an immunogenic agent. The BCG revaccination complications are much less known because there are only few publications in the literature. In our case, the mechanism may have been infectious or imply immune reaction with Arthus’type-phenomenon and/or a type IV hypersensitivity. Conclusion. Adverse reactions due to revaccination are rarely described should became lessfrequentwhentheBCGrevaccinationisabandonedfollowing the decision of French regulatory authorities. Nevertheless, such complications can occur by accident, as the case in our patient.
