To determine the impact of an aborted radical hysterectomy on morbidity and overall survival in patients undergoing surgical treatment for early stage cervical carcinoma. Following IRB approval, a computerized databas...To determine the impact of an aborted radical hysterectomy on morbidity and overall survival in patients undergoing surgical treatment for early stage cervical carcinoma. Following IRB approval, a computerized database identified 304 women treated with radical surgery for early stage cervical carcinoma from 1994 to 2000 of which 23 (8% ) had an aborted radical hysterectomy. Of the 23 patients, 17 patients had a IB1 lesion, 4 patients had a IB 2 lesion, and 2 patients had a IIA lesion. Median age was 42 years (range 28- 60). Twenty- one patients had squamous cell carcinoma and two patients had adenocarcinoma. Radical hysterectomywas aborted for the following reasons: 11 patients had pelvic extension, seven had positive pelvic nodes, and five patients had positive paraaortic nodes. All 23 patients received postoperative radiation therapy; additionally, 12 patients received concurrent chemotherapy consisting of platinum with or without 5- FU. There were four operative complications (17% ) including deep vein thrombosis, wound infection, blood transfusion, and an ileus. Four patients (17% ) had radiationassociated complications. Six of 23 (26% ) patients experienced a recurrence. The 5- year overall survival was 83% with a median follow- up of 59 months (range 12- 107 months). A small percentage of patients (8% ) with early stage cervical carcinoma will have an aborted radical hysterectomy for pelvic extension or positive nodes. Fortunately, these patients still have a favorable prognosis with postoperative radiation therapy. Aborted radical surgery does not significantly increase overall complications.展开更多
文摘To determine the impact of an aborted radical hysterectomy on morbidity and overall survival in patients undergoing surgical treatment for early stage cervical carcinoma. Following IRB approval, a computerized database identified 304 women treated with radical surgery for early stage cervical carcinoma from 1994 to 2000 of which 23 (8% ) had an aborted radical hysterectomy. Of the 23 patients, 17 patients had a IB1 lesion, 4 patients had a IB 2 lesion, and 2 patients had a IIA lesion. Median age was 42 years (range 28- 60). Twenty- one patients had squamous cell carcinoma and two patients had adenocarcinoma. Radical hysterectomywas aborted for the following reasons: 11 patients had pelvic extension, seven had positive pelvic nodes, and five patients had positive paraaortic nodes. All 23 patients received postoperative radiation therapy; additionally, 12 patients received concurrent chemotherapy consisting of platinum with or without 5- FU. There were four operative complications (17% ) including deep vein thrombosis, wound infection, blood transfusion, and an ileus. Four patients (17% ) had radiationassociated complications. Six of 23 (26% ) patients experienced a recurrence. The 5- year overall survival was 83% with a median follow- up of 59 months (range 12- 107 months). A small percentage of patients (8% ) with early stage cervical carcinoma will have an aborted radical hysterectomy for pelvic extension or positive nodes. Fortunately, these patients still have a favorable prognosis with postoperative radiation therapy. Aborted radical surgery does not significantly increase overall complications.
