AIM:To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and signifi cance of their expression in gastric carcinoma and precancerous lesions.METHODS: Th...AIM:To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and signifi cance of their expression in gastric carcinoma and precancerous lesions.METHODS: The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric carcinoma.RESULTS: The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P<0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P<0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk=0.279, P<0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P<0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was signifi cantly higher than that in the group without lymph node metastasis (41.2%), P<0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk=0.246, P<0.01.CONCLUSION: YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.展开更多
近年来乳腺癌发病率有上升趋势,现已成为妇女第一位恶性肿瘤。乳腺X线检查作为乳腺癌的筛检手段、诊断方法已越来越引起重视,规范乳腺X线报告已非常必要。美国放射学会在20世纪90年代提出的乳腺影像报告和数据系统(breast imaging repor...近年来乳腺癌发病率有上升趋势,现已成为妇女第一位恶性肿瘤。乳腺X线检查作为乳腺癌的筛检手段、诊断方法已越来越引起重视,规范乳腺X线报告已非常必要。美国放射学会在20世纪90年代提出的乳腺影像报告和数据系统(breast imaging reporting and data system,BI-RADS),在规范乳腺X线报告,帮助临床医生对病变处理作出合理选择,在不同医疗机构之间的归一研究和乳腺X线检查随访的监测等方面均起着至关重要的作用。我们的应用显示,基于乳腺癌筛查而产生的这个系统同样也适应于乳腺病变检查人群。展开更多
基金Supported by National Natural Science Foundation of China,No.30371607
文摘AIM:To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and signifi cance of their expression in gastric carcinoma and precancerous lesions.METHODS: The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric carcinoma.RESULTS: The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P<0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P<0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk=0.279, P<0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P<0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was signifi cantly higher than that in the group without lymph node metastasis (41.2%), P<0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk=0.246, P<0.01.CONCLUSION: YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.
文摘近年来乳腺癌发病率有上升趋势,现已成为妇女第一位恶性肿瘤。乳腺X线检查作为乳腺癌的筛检手段、诊断方法已越来越引起重视,规范乳腺X线报告已非常必要。美国放射学会在20世纪90年代提出的乳腺影像报告和数据系统(breast imaging reporting and data system,BI-RADS),在规范乳腺X线报告,帮助临床医生对病变处理作出合理选择,在不同医疗机构之间的归一研究和乳腺X线检查随访的监测等方面均起着至关重要的作用。我们的应用显示,基于乳腺癌筛查而产生的这个系统同样也适应于乳腺病变检查人群。
