Cyanopyridine was at first catalytically hydrolyzed to give isonicotinamide in the presence of Mg-Fe oxides with yield 92%. 4-Aminopyridine was obtained from isonicotinamide in yield of 83%～85% by Hofmann reaction us...Cyanopyridine was at first catalytically hydrolyzed to give isonicotinamide in the presence of Mg-Fe oxides with yield 92%. 4-Aminopyridine was obtained from isonicotinamide in yield of 83%～85% by Hofmann reaction using iodo-benzene as catalyst. All of the reaction were monitored by TLC and the products were confirmed by IR, NMR and melting point determination.展开更多
文摘Cyanopyridine was at first catalytically hydrolyzed to give isonicotinamide in the presence of Mg-Fe oxides with yield 92%. 4-Aminopyridine was obtained from isonicotinamide in yield of 83%～85% by Hofmann reaction using iodo-benzene as catalyst. All of the reaction were monitored by TLC and the products were confirmed by IR, NMR and melting point determination.
