药品不良反应（Adverse drug reaction,ADR）是指合格的药品在正常用法用量下出现的与用药目的无关的有害反应,每个药品都可能导致不良反应,因此临床用药过程中对ADR的监测工作非常重要,也非常有意义[1]。为了促进临床合理用药,提高药...药品不良反应（Adverse drug reaction,ADR）是指合格的药品在正常用法用量下出现的与用药目的无关的有害反应,每个药品都可能导致不良反应,因此临床用药过程中对ADR的监测工作非常重要,也非常有意义[1]。为了促进临床合理用药,提高药品使用安全性,本研究对2017年我院收集的药品不良反应报表进行回顾分析,以期掌握药品不良反应发生的情况、特点,旨在警示临床合理、安全用药，尽量避免ADR的发生，现报道如下。展开更多
Morphine also produces unexpected,paradoxical pain in the clinical utility for the treatment of many types of pain in addition to analgesia.Long-term morphine use is associated with tolerance,which has been recognized...Morphine also produces unexpected,paradoxical pain in the clinical utility for the treatment of many types of pain in addition to analgesia.Long-term morphine use is associated with tolerance,which has been recognized for long time.Recently,it has become increasingly clear that morphine-induced tolerance is accompanied with enhanced pain sensitivity,and they have some same mechanisms.This article elucidates the potential mechanisms for morphine-induced hyperalgesia and allodynia,for example,excitatory opioid receptor,NMDA receptor,anti-opioid eptids,descending facilitation system,and neuroimmune system,which maybe provide some new methods in clinical utility of morphine.展开更多
文摘药品不良反应（Adverse drug reaction,ADR）是指合格的药品在正常用法用量下出现的与用药目的无关的有害反应,每个药品都可能导致不良反应,因此临床用药过程中对ADR的监测工作非常重要,也非常有意义[1]。为了促进临床合理用药,提高药品使用安全性,本研究对2017年我院收集的药品不良反应报表进行回顾分析,以期掌握药品不良反应发生的情况、特点,旨在警示临床合理、安全用药，尽量避免ADR的发生，现报道如下。
文摘Morphine also produces unexpected,paradoxical pain in the clinical utility for the treatment of many types of pain in addition to analgesia.Long-term morphine use is associated with tolerance,which has been recognized for long time.Recently,it has become increasingly clear that morphine-induced tolerance is accompanied with enhanced pain sensitivity,and they have some same mechanisms.This article elucidates the potential mechanisms for morphine-induced hyperalgesia and allodynia,for example,excitatory opioid receptor,NMDA receptor,anti-opioid eptids,descending facilitation system,and neuroimmune system,which maybe provide some new methods in clinical utility of morphine.
