Objective: To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of ...Objective: To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of Atherosclerosis (MESA). Design: Prospective cohort study. Participants: Six thousand one hundred seventy-six 45- to 85- year-old subjects selected from 6 United States communities. Methods: Fundus images were taken using a 45° digital camera through dark-adapted pupils and were graded for drusen size, type, area, increased retinal pigment, retinal pigment epithelial depigmentation, neovascular lesions, and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System. Main Outcome Measure: Age-related macular degeneration. Results: Prevalences of AMD were 2.4% (black), 4.2% (Hispanic), 4.6% (Chinese), to 5.4% (white) (P<0.001 for any differences among groups). The highest prevalence of any AMD occurred in those 75 to 84 years old, varying from 7.4% in blacks to 15.8% in whites and Chinese (P=0.03). Estimated prevalences of late AMD were 0.3% (black), 0.2% (Hispanic), 0.6% (white), and 1.0% (Chinese). These differences were marginally significant (age and gender adjusted, P=0.08). The frequency of exudative AMD was highest in Chinese (age-and gender-adjusted odds ratio, 4.30; 95% confidence interval, 1.30- 14.27) compared with whites. Differences in age, gender, pupil size, body mass index, smoking, alcohol drinking history, diabetes, and hypertension status did not explain the variability among the 4 racial/ethnic groups. Conclusions: Low prevalences of AMD were found in the MESA cohort in all groups. A lower prevalence of AMD was found in blacks compared with whites. The higher prevalence of exudative AMD in Chinese needs further study.展开更多
玻璃样钙化物质出现在视乳头部位称为视乳头玻璃疣（drusen of the optic disc），大多数患者为双眼发病，因所在的位置不同而有不同的临床表现。深埋在视神经组织内者称为埋藏视乳头玻璃疣（buried optic disc drusen）。位于筛板前的...玻璃样钙化物质出现在视乳头部位称为视乳头玻璃疣（drusen of the optic disc），大多数患者为双眼发病，因所在的位置不同而有不同的临床表现。深埋在视神经组织内者称为埋藏视乳头玻璃疣（buried optic disc drusen）。位于筛板前的埋藏玻璃疣可压迫视神经或血管引起前部缺血性视神经病变（anterior ischaemic optic neuropathy,AION）.展开更多
埋藏性视盘玻璃疣(buried optic disk drusen,BODD)多见于儿童和青少年,临床上较少见[1],不同的疣体位置及大小可表现出不同的症状,也可无症状,患者多因“视物模糊或眼前黑影”就诊,眼底出血多在1~3个月之内完全吸收,视力恢复[2],本病...埋藏性视盘玻璃疣(buried optic disk drusen,BODD)多见于儿童和青少年,临床上较少见[1],不同的疣体位置及大小可表现出不同的症状,也可无症状,患者多因“视物模糊或眼前黑影”就诊,眼底出血多在1~3个月之内完全吸收,视力恢复[2],本病也可诱发视网膜中央动。展开更多
文摘Objective: To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of Atherosclerosis (MESA). Design: Prospective cohort study. Participants: Six thousand one hundred seventy-six 45- to 85- year-old subjects selected from 6 United States communities. Methods: Fundus images were taken using a 45° digital camera through dark-adapted pupils and were graded for drusen size, type, area, increased retinal pigment, retinal pigment epithelial depigmentation, neovascular lesions, and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System. Main Outcome Measure: Age-related macular degeneration. Results: Prevalences of AMD were 2.4% (black), 4.2% (Hispanic), 4.6% (Chinese), to 5.4% (white) (P<0.001 for any differences among groups). The highest prevalence of any AMD occurred in those 75 to 84 years old, varying from 7.4% in blacks to 15.8% in whites and Chinese (P=0.03). Estimated prevalences of late AMD were 0.3% (black), 0.2% (Hispanic), 0.6% (white), and 1.0% (Chinese). These differences were marginally significant (age and gender adjusted, P=0.08). The frequency of exudative AMD was highest in Chinese (age-and gender-adjusted odds ratio, 4.30; 95% confidence interval, 1.30- 14.27) compared with whites. Differences in age, gender, pupil size, body mass index, smoking, alcohol drinking history, diabetes, and hypertension status did not explain the variability among the 4 racial/ethnic groups. Conclusions: Low prevalences of AMD were found in the MESA cohort in all groups. A lower prevalence of AMD was found in blacks compared with whites. The higher prevalence of exudative AMD in Chinese needs further study.
