AIM： To investigate whether microproteinuria in patients with inflammatory bowel disease （IBD） is associated with the disease activity or the treatment with 5-aminosalicylic acid （5-ASA）. METHODS： We prospective...AIM： To investigate whether microproteinuria in patients with inflammatory bowel disease （IBD） is associated with the disease activity or the treatment with 5-aminosalicylic acid （5-ASA）. METHODS： We prospectively studied microproteinuria in 86 consecutive patients with IBD, 61 with ulcerative colitis （UC） and 25 with Crohn＇s disease （CD）, before as well as 2 and 6 months after their inclusion in the study. Forty-six patients received 5-ASA for a period of 28.8 months （range 1-168 too）. Microalbuminuria （mALB） and urine levels of the renal tubular proteins β2-microglobulin （β2mGLB） and β-N-acetyI-D-glucosamidase （β-NAG） as well as the creatinine clearance were determined in a 12-h overnight urine collection. Tumor necrosis factor-α （TNF-α） serum levels were also measured. RESULTS： A total of 277 measurements （194 in UC patients and 83 in CD patients） were performed. The prevalence of abnormal microoproteinuria in UC and CD patients was 12.9% and 6.0% for mALB, 22.7% and 27.7% for B2mGLB, and 11.3% and 8.4% for β-NAG, respectively, mALB was not associated with IBD activity. β2mGLB and B-NAG urine levels were correlated to UC activity （UCAI： P〈0.01; UCEI： P〈0.005）. mALB in UC patients and β-NAG urine levels in CD patients were related to TNF-α serum levels. An association was noticed between microproteinuria and smoking habit. Treatment with 5-ASA was not correlated to the severity of microproteinuria or to the changes of creatinine clearance.CONCLUSION： Microproteinuria is mainly associated with UC and its activity but not affected by 5-ASA.展开更多
目的了解炎症性肠病患者对疾病相关知识的掌握情况和对健康教育的需求，为针对性的健康指导提供依据。方法采用中文版克罗恩病与溃疡性结肠炎知识问卷（Crohn＇s and Colitis Knowledge Score,CCKNOW）对106例炎症性肠病患者进行问卷调...目的了解炎症性肠病患者对疾病相关知识的掌握情况和对健康教育的需求，为针对性的健康指导提供依据。方法采用中文版克罗恩病与溃疡性结肠炎知识问卷（Crohn＇s and Colitis Knowledge Score,CCKNOW）对106例炎症性肠病患者进行问卷调查.结果炎症性肠病患者CCKNOW总分为（5．82±4．66）分；其中78例溃疡性结肠炎患者为（5．42±4．44）分，28例克罗恩病患者为（6．61±4．92）分，差异无统计学意义（P〉0．05）。问巷4个维度的问题回答正确率分别为：饮食知识32％～39％，药物知识27％-36％，一般知识22％～28％，并发症知识20％～21％.患者的文化程度和病程是其知识水平的主要影响因素；97．2％的患者对药物和非药物治疗知识有较高需求，90．6％的患者对并发症知识需求强烈;患者疾病知识来源主要是医务人员。结论炎症性肠病患者疾病相关知识知晓率总体水平较低，对药物、非药物治疗知识和并发症方面知识有较高需求。护理人员应根据炎症性肠病患者对疾病知识的掌握程度、不同文化程度和健康教育的不同需求，给予针对性的健康指导，从而促进炎症性肠病患者的健康行为，提高其生活质量．展开更多
目的检索和分析炎症性肠病患者焦虑和抑郁管理的相关证据,并对最佳证据进行总结。方法计算机检索BMJ Best Practice、JBI循证卫生保健中心数据库、UptoDate、美国指南网、英国国家临床医学研究所指南库、苏格兰校际指南网、世界胃肠病...目的检索和分析炎症性肠病患者焦虑和抑郁管理的相关证据,并对最佳证据进行总结。方法计算机检索BMJ Best Practice、JBI循证卫生保健中心数据库、UptoDate、美国指南网、英国国家临床医学研究所指南库、苏格兰校际指南网、世界胃肠病组织网、PubMed、Cochrane Library、Embase、CINAHL、PsycInfo、中国生物医学文献数据库、CNKI和万方数据库中有关炎症性肠病患者焦虑和抑郁管理的指南、证据总结、专家共识、最佳信息实践册、推荐实践和系统评价。检索时限为建库至2020年4月20日。对纳入文献进行质量评价和证据汇总。结果共纳入12篇文献,其中指南3篇、专家共识3篇、系统评价6篇。最终提取并综合成筛查、评估和管理共3个层面、20条证据,其中管理维度又可以细化为信息支持、情感支持、心理干预、戒烟戒酒、运动锻炼5个方面。结论应用证据时需结合机构的环境、现有条件、决策者意愿、患者意愿及证据应用的促进、障碍因素,对证据进行个体化调整,以科学的方式管理炎症性肠病患者的心理问题,保证护理质量。展开更多
文摘AIM： To investigate whether microproteinuria in patients with inflammatory bowel disease （IBD） is associated with the disease activity or the treatment with 5-aminosalicylic acid （5-ASA）. METHODS： We prospectively studied microproteinuria in 86 consecutive patients with IBD, 61 with ulcerative colitis （UC） and 25 with Crohn＇s disease （CD）, before as well as 2 and 6 months after their inclusion in the study. Forty-six patients received 5-ASA for a period of 28.8 months （range 1-168 too）. Microalbuminuria （mALB） and urine levels of the renal tubular proteins β2-microglobulin （β2mGLB） and β-N-acetyI-D-glucosamidase （β-NAG） as well as the creatinine clearance were determined in a 12-h overnight urine collection. Tumor necrosis factor-α （TNF-α） serum levels were also measured. RESULTS： A total of 277 measurements （194 in UC patients and 83 in CD patients） were performed. The prevalence of abnormal microoproteinuria in UC and CD patients was 12.9% and 6.0% for mALB, 22.7% and 27.7% for B2mGLB, and 11.3% and 8.4% for β-NAG, respectively, mALB was not associated with IBD activity. β2mGLB and B-NAG urine levels were correlated to UC activity （UCAI： P〈0.01; UCEI： P〈0.005）. mALB in UC patients and β-NAG urine levels in CD patients were related to TNF-α serum levels. An association was noticed between microproteinuria and smoking habit. Treatment with 5-ASA was not correlated to the severity of microproteinuria or to the changes of creatinine clearance.CONCLUSION： Microproteinuria is mainly associated with UC and its activity but not affected by 5-ASA.
文摘目的了解炎症性肠病患者对疾病相关知识的掌握情况和对健康教育的需求，为针对性的健康指导提供依据。方法采用中文版克罗恩病与溃疡性结肠炎知识问卷（Crohn＇s and Colitis Knowledge Score,CCKNOW）对106例炎症性肠病患者进行问卷调查.结果炎症性肠病患者CCKNOW总分为（5．82±4．66）分；其中78例溃疡性结肠炎患者为（5．42±4．44）分，28例克罗恩病患者为（6．61±4．92）分，差异无统计学意义（P〉0．05）。问巷4个维度的问题回答正确率分别为：饮食知识32％～39％，药物知识27％-36％，一般知识22％～28％，并发症知识20％～21％.患者的文化程度和病程是其知识水平的主要影响因素；97．2％的患者对药物和非药物治疗知识有较高需求，90．6％的患者对并发症知识需求强烈;患者疾病知识来源主要是医务人员。结论炎症性肠病患者疾病相关知识知晓率总体水平较低，对药物、非药物治疗知识和并发症方面知识有较高需求。护理人员应根据炎症性肠病患者对疾病知识的掌握程度、不同文化程度和健康教育的不同需求，给予针对性的健康指导，从而促进炎症性肠病患者的健康行为，提高其生活质量．
文摘目的检索和分析炎症性肠病患者焦虑和抑郁管理的相关证据,并对最佳证据进行总结。方法计算机检索BMJ Best Practice、JBI循证卫生保健中心数据库、UptoDate、美国指南网、英国国家临床医学研究所指南库、苏格兰校际指南网、世界胃肠病组织网、PubMed、Cochrane Library、Embase、CINAHL、PsycInfo、中国生物医学文献数据库、CNKI和万方数据库中有关炎症性肠病患者焦虑和抑郁管理的指南、证据总结、专家共识、最佳信息实践册、推荐实践和系统评价。检索时限为建库至2020年4月20日。对纳入文献进行质量评价和证据汇总。结果共纳入12篇文献,其中指南3篇、专家共识3篇、系统评价6篇。最终提取并综合成筛查、评估和管理共3个层面、20条证据,其中管理维度又可以细化为信息支持、情感支持、心理干预、戒烟戒酒、运动锻炼5个方面。结论应用证据时需结合机构的环境、现有条件、决策者意愿、患者意愿及证据应用的促进、障碍因素,对证据进行个体化调整,以科学的方式管理炎症性肠病患者的心理问题,保证护理质量。
