PURPOSE: To report on a case of bilateral conjunctival lymphoid hyperplasia pr esenting with bilateral panuveitis in a female patient. DESIGN: Observational ca se report. METHODS: In this case excisional biopsy indica...PURPOSE: To report on a case of bilateral conjunctival lymphoid hyperplasia pr esenting with bilateral panuveitis in a female patient. DESIGN: Observational ca se report. METHODS: In this case excisional biopsy indicated lymphoid tissue. Im munohistochemistry showed a follicular architecture with appropriate zoning of B and T lymphocytes. RESULTS: Causes of panuveitis were considered and excluded b ased on a detailed history, physical examination, and laboratory investigations. The bilateral panuveitis resolved on topical corticosteroids and visual acuity returned to normal. CONCLUSIONS: Ocular adnexal lymphoproliferative lesions cons ist of a spectrum of disease entities, including reactive lymphoid hyperplasia, atypical lymphoid hyperplasia, and lymphoma. There are no established clinical c riteria to differentiate between these lesions. This case highlights the importa nce of a thorough ophthalmic examination in these patients, as an intra-ocular inflammatory process may accompany the conjunctival findings. Futhermore, we adv ocate periodic follow-up examinations because of the small potential risk of de veloping ocular or systemic lymphoma in these patients.展开更多
Follicular malignant melanoma can be regarded as a rare and unique presentation ofmelanoma. It is characterized by a deepseated follicular structure in which atypicalmelanocytes extend downward along the follicular ep...Follicular malignant melanoma can be regarded as a rare and unique presentation ofmelanoma. It is characterized by a deepseated follicular structure in which atypicalmelanocytes extend downward along the follicular epitheliumand permeate parts of the follicle as well as the adjacent dermis. The clinical diagnosis of follicular malignant melanoma may be difficult because the tumor mostly resembles a comedo or a pigmented cyst. We studied five cases of follicular malignant melanoma in which the patients were between 61 and 82 years old. Three lesions were localized on the nose, one on the cheek, and one on the back of the neck. Clinically, all five cases measured distinctly less than 0.5 cm in size. While lentigo maligna is traditionally known as a pigmented macule in actinically damaged skin that gradually evolves in a slow process before invasive growth, three follicular malignant melanomas had developed in relatively short timeframes of 9 months to 1 1/2 years. In all five cases the inconspicuous clinical appearance did not herald a malignant melanoma with invasive growth. Follicular malignant melanoma underlines the importance of a correct excision technique with subsequent histologic workup and diagnosis. Superficial shave excision or even laser treatment in these specific cases may lead to a fatal prognosis for the patient.展开更多
目的探讨甲状腺滤泡癌样肾细胞癌(thyroid-likefollicular carcinoma of the kidney,TLFCK)临床病理特点。方法对1例TLFCK患者的临床资料、病理学检查及免疫表型结果进行分析,并复习相关文献。结果患者男性,66岁,反复全程肉眼血尿4年余...目的探讨甲状腺滤泡癌样肾细胞癌(thyroid-likefollicular carcinoma of the kidney,TLFCK)临床病理特点。方法对1例TLFCK患者的临床资料、病理学检查及免疫表型结果进行分析,并复习相关文献。结果患者男性,66岁,反复全程肉眼血尿4年余。术中切除肿物16 cm×7 cm×6 cm大小,该肿瘤累犯肾实质及肾盂,累及肾被膜与肾周脂肪。镜检:肿瘤主要由甲状腺滤泡样结构构成,另见坏死、乳头状结构区域、实性区等。免疫表型:CKpan、vimentin、EMA、NSE等呈弥漫性强阳性,TG、TTF-1、WT1、CD117、AM-ACR等均呈阴性。结论 TLFCK是一种极其罕见的肾脏肿瘤类型,应提高对该肿瘤的认识,避免误诊。展开更多
文摘PURPOSE: To report on a case of bilateral conjunctival lymphoid hyperplasia pr esenting with bilateral panuveitis in a female patient. DESIGN: Observational ca se report. METHODS: In this case excisional biopsy indicated lymphoid tissue. Im munohistochemistry showed a follicular architecture with appropriate zoning of B and T lymphocytes. RESULTS: Causes of panuveitis were considered and excluded b ased on a detailed history, physical examination, and laboratory investigations. The bilateral panuveitis resolved on topical corticosteroids and visual acuity returned to normal. CONCLUSIONS: Ocular adnexal lymphoproliferative lesions cons ist of a spectrum of disease entities, including reactive lymphoid hyperplasia, atypical lymphoid hyperplasia, and lymphoma. There are no established clinical c riteria to differentiate between these lesions. This case highlights the importa nce of a thorough ophthalmic examination in these patients, as an intra-ocular inflammatory process may accompany the conjunctival findings. Futhermore, we adv ocate periodic follow-up examinations because of the small potential risk of de veloping ocular or systemic lymphoma in these patients.
文摘Follicular malignant melanoma can be regarded as a rare and unique presentation ofmelanoma. It is characterized by a deepseated follicular structure in which atypicalmelanocytes extend downward along the follicular epitheliumand permeate parts of the follicle as well as the adjacent dermis. The clinical diagnosis of follicular malignant melanoma may be difficult because the tumor mostly resembles a comedo or a pigmented cyst. We studied five cases of follicular malignant melanoma in which the patients were between 61 and 82 years old. Three lesions were localized on the nose, one on the cheek, and one on the back of the neck. Clinically, all five cases measured distinctly less than 0.5 cm in size. While lentigo maligna is traditionally known as a pigmented macule in actinically damaged skin that gradually evolves in a slow process before invasive growth, three follicular malignant melanomas had developed in relatively short timeframes of 9 months to 1 1/2 years. In all five cases the inconspicuous clinical appearance did not herald a malignant melanoma with invasive growth. Follicular malignant melanoma underlines the importance of a correct excision technique with subsequent histologic workup and diagnosis. Superficial shave excision or even laser treatment in these specific cases may lead to a fatal prognosis for the patient.
文摘目的探讨甲状腺滤泡癌样肾细胞癌(thyroid-likefollicular carcinoma of the kidney,TLFCK)临床病理特点。方法对1例TLFCK患者的临床资料、病理学检查及免疫表型结果进行分析,并复习相关文献。结果患者男性,66岁,反复全程肉眼血尿4年余。术中切除肿物16 cm×7 cm×6 cm大小,该肿瘤累犯肾实质及肾盂,累及肾被膜与肾周脂肪。镜检:肿瘤主要由甲状腺滤泡样结构构成,另见坏死、乳头状结构区域、实性区等。免疫表型:CKpan、vimentin、EMA、NSE等呈弥漫性强阳性,TG、TTF-1、WT1、CD117、AM-ACR等均呈阴性。结论 TLFCK是一种极其罕见的肾脏肿瘤类型,应提高对该肿瘤的认识,避免误诊。
