We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. An 80-year-old man was admitted to our clinic for further investigation of a fever of unknown origin. He noted anorexia, ...We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. An 80-year-old man was admitted to our clinic for further investigation of a fever of unknown origin. He noted anorexia, weight loss and fatigue. His laboratory tests showed anemia and a great elevation of ESR, LDH, and β2 microglobulin. In CT and MRI scan, a soft tissue mass in the pancreas was observed. A repeated endoscopy after his admission revealed an ulcerated mass-like deformity of the duodenal bulb. Explorative laparotomy confirmed a diffuse spread of an unresectable malignant pancreatic mass extending to the adjacent organs. Duodenal and surgical biopsies identified an ALCL of T-cell lineage, ALK-. The patient died in the Intensive Care Unit due to hemodynamic instability.Our case is the first one indicating that primary pancreatic lymphoma should be suspected in a patient with pancreatic mass and elevated serum LDH and β2 microglobulin.展开更多
Background: Adult T- cell leukaemia/lymphoma (ATLL) is a human malignancy associated with human T- cell leukaemia virus type I (HTLV- I). ATLL frequently involves the skin. Objectives: To correlate the clinicopatholog...Background: Adult T- cell leukaemia/lymphoma (ATLL) is a human malignancy associated with human T- cell leukaemia virus type I (HTLV- I). ATLL frequently involves the skin. Objectives: To correlate the clinicopathological features and prognosis in patients with ATLL and cutaneous lesions. Methods: We examined the HTLV- I proviral state and the clinicopathological features of the cutaneous lesions in 80 patients with serum anti- ATL antibody, to clarify the correlation between macroscopic/histopathological findings and prognosis. Southern blot analysis was performed in all cases to detect monoclonal HTLV- I proviral DNA integration. Results: The cutaneous lesions of 46 patients were positive for proviral DNA integration. The median survival time of patients with monoclonal proviral DNA integration in cutaneous lesions was 14 months, which was markedly shorter than that of patients negative for proviral DNA integration (72 months). Of the 46 patients with proviral DNA, 21 had solitary or multiple red nodules (including three with subcutaneous induration), eight had multiple red papules and 17 had erythema. Patients with papules and nodules had poorer prognosis than those with erythema. Histopathologically, the prognosis was poorer in patients with nodular or diffuse infiltration of medium- sized to large lymphoma cells, compared with those with perivascular infiltration of small to medium- sized lymphoma cells. Conclusions: Our results show a close correlation between clinicopathological features of HTLV- I- associated cutaneous lesions and prognosis.展开更多
炎性乳腺癌曾有过许多不同的名称,包括癌性乳腺炎(mastiffs carcinomatosa)、急性乳腺癌(acute mammary carcinoma)、急性硬结癌(acute brawny cancer)、急性硬化性癌(acutescirrhous carcinoma)、乳腺淋巴细胞瘤(lymphocytoma of the b...炎性乳腺癌曾有过许多不同的名称,包括癌性乳腺炎(mastiffs carcinomatosa)、急性乳腺癌(acute mammary carcinoma)、急性硬结癌(acute brawny cancer)、急性硬化性癌(acutescirrhous carcinoma)、乳腺淋巴细胞瘤(lymphocytoma of the breast)。展开更多
We report the case of a 41-year-old patient with an aggressive cutaneous T-cell lymphoma (CTCL) initially presenting on histology as lymphocytic vasculitis. On repeated histological examination and by molecular biolog...We report the case of a 41-year-old patient with an aggressive cutaneous T-cell lymphoma (CTCL) initially presenting on histology as lymphocytic vasculitis. On repeated histological examination and by molecular biology work-up, the diagnosis of an unclassifiable CTCL could eventually be established. This atypical poorly differentiated lymphoma was of a CD4+CD8-CD56-phenotype and followed an unfavourable course. The patient died despite chemoand immunotherapy 7 months after the first consideration of lymphoma as diagnosis.展开更多
文摘We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. An 80-year-old man was admitted to our clinic for further investigation of a fever of unknown origin. He noted anorexia, weight loss and fatigue. His laboratory tests showed anemia and a great elevation of ESR, LDH, and β2 microglobulin. In CT and MRI scan, a soft tissue mass in the pancreas was observed. A repeated endoscopy after his admission revealed an ulcerated mass-like deformity of the duodenal bulb. Explorative laparotomy confirmed a diffuse spread of an unresectable malignant pancreatic mass extending to the adjacent organs. Duodenal and surgical biopsies identified an ALCL of T-cell lineage, ALK-. The patient died in the Intensive Care Unit due to hemodynamic instability.Our case is the first one indicating that primary pancreatic lymphoma should be suspected in a patient with pancreatic mass and elevated serum LDH and β2 microglobulin.
文摘Background: Adult T- cell leukaemia/lymphoma (ATLL) is a human malignancy associated with human T- cell leukaemia virus type I (HTLV- I). ATLL frequently involves the skin. Objectives: To correlate the clinicopathological features and prognosis in patients with ATLL and cutaneous lesions. Methods: We examined the HTLV- I proviral state and the clinicopathological features of the cutaneous lesions in 80 patients with serum anti- ATL antibody, to clarify the correlation between macroscopic/histopathological findings and prognosis. Southern blot analysis was performed in all cases to detect monoclonal HTLV- I proviral DNA integration. Results: The cutaneous lesions of 46 patients were positive for proviral DNA integration. The median survival time of patients with monoclonal proviral DNA integration in cutaneous lesions was 14 months, which was markedly shorter than that of patients negative for proviral DNA integration (72 months). Of the 46 patients with proviral DNA, 21 had solitary or multiple red nodules (including three with subcutaneous induration), eight had multiple red papules and 17 had erythema. Patients with papules and nodules had poorer prognosis than those with erythema. Histopathologically, the prognosis was poorer in patients with nodular or diffuse infiltration of medium- sized to large lymphoma cells, compared with those with perivascular infiltration of small to medium- sized lymphoma cells. Conclusions: Our results show a close correlation between clinicopathological features of HTLV- I- associated cutaneous lesions and prognosis.
文摘炎性乳腺癌曾有过许多不同的名称,包括癌性乳腺炎(mastiffs carcinomatosa)、急性乳腺癌(acute mammary carcinoma)、急性硬结癌(acute brawny cancer)、急性硬化性癌(acutescirrhous carcinoma)、乳腺淋巴细胞瘤(lymphocytoma of the breast)。
文摘We report the case of a 41-year-old patient with an aggressive cutaneous T-cell lymphoma (CTCL) initially presenting on histology as lymphocytic vasculitis. On repeated histological examination and by molecular biology work-up, the diagnosis of an unclassifiable CTCL could eventually be established. This atypical poorly differentiated lymphoma was of a CD4+CD8-CD56-phenotype and followed an unfavourable course. The patient died despite chemoand immunotherapy 7 months after the first consideration of lymphoma as diagnosis.
