目的探讨血清淀粉样蛋白A(Serum Amyloid A Protein SAA)、超敏C-反应蛋白(hs-CRP)和血清降钙素原(PCT)对原发性肺癌患者肺部感染病原菌的诊断效果。方法选取2015年7月-2018年7月于广东省第二人民医院接受治疗的314例原发性肺癌患者为...目的探讨血清淀粉样蛋白A(Serum Amyloid A Protein SAA)、超敏C-反应蛋白(hs-CRP)和血清降钙素原(PCT)对原发性肺癌患者肺部感染病原菌的诊断效果。方法选取2015年7月-2018年7月于广东省第二人民医院接受治疗的314例原发性肺癌患者为研究对象,按照患者住院过程中是否发生感染分为细菌感染组、病毒感染组、真菌感染组、非感染组。检测各组患者血清SAA、hs-CRP、PCT指标水平。并采用受试者工作曲线(ROC)对细菌感染患者、病毒感染患者血清SAA、hs-CRP、PCT指标诊断价值进行评价。结果原发性肺癌患者细菌感染组血清SAA、hs-CRP、PCT指标水平明显高于病毒感染组、真菌感染组和非感染组(P<0.05),非感染组血清SAA、hs-CRP、PCT指标水平最低。SAA诊断原发性肺癌患者细菌感染的敏感度、特异度、阳性似然值分别为0.837、0.973、0.168,诊断病毒感染的敏感度、特异度、阳性似然值分别为0.532、0.940、0.494,均优于hs-CRP和PCT。结论原发性肺癌患者发生肺部感染后血清SAA、hs-CRP、PCT指标水平变化明显,血清SAA、hs-CRP、PCT诊断细菌感染患者较病毒感染患者准确性高,临床医师可以根据血清SAA、hs-CRP、PCT检测结果对患者肺部感染情况进行初步判断。展开更多
β-amyloid (Aβ) and copper play important roles in the pathogenesis of Alzheimer’s disease (AD).However,the behavioral correlativity and molecular mechanisms of Aβ and copper toxicity have been investigated less of...β-amyloid (Aβ) and copper play important roles in the pathogenesis of Alzheimer’s disease (AD).However,the behavioral correlativity and molecular mechanisms of Aβ and copper toxicity have been investigated less often.In the present study,we investigated the interaction and toxicity of Aβ1-42 and copper in the Aβ1-42 transgenic Caenorhabditis elegans worm model CL2006.Our data show that the paralysis behavior of CL2006 worms significantly deteriorated after exposure to 10-3 mol L-1 copper ions.However,the paralysis behavior was dramatically attenuated with exposure to 10-4 mol L-1 copper ions.The exogenous copper treatment also partially changed the homeostatic balance of zinc,manganese,and iron.Our data suggest that the accumulation of reactive oxygen species (ROS) was responsible for the paralysis induced by Aβ and copper in CL2006.The ROS generation induced by Aβ and copper appear to be through sod-1,prdx-2,skn-1,hsp-60 and hsp-16.2 genes.展开更多
文摘目的探讨血清淀粉样蛋白A(Serum Amyloid A Protein SAA)、超敏C-反应蛋白(hs-CRP)和血清降钙素原(PCT)对原发性肺癌患者肺部感染病原菌的诊断效果。方法选取2015年7月-2018年7月于广东省第二人民医院接受治疗的314例原发性肺癌患者为研究对象,按照患者住院过程中是否发生感染分为细菌感染组、病毒感染组、真菌感染组、非感染组。检测各组患者血清SAA、hs-CRP、PCT指标水平。并采用受试者工作曲线(ROC)对细菌感染患者、病毒感染患者血清SAA、hs-CRP、PCT指标诊断价值进行评价。结果原发性肺癌患者细菌感染组血清SAA、hs-CRP、PCT指标水平明显高于病毒感染组、真菌感染组和非感染组(P<0.05),非感染组血清SAA、hs-CRP、PCT指标水平最低。SAA诊断原发性肺癌患者细菌感染的敏感度、特异度、阳性似然值分别为0.837、0.973、0.168,诊断病毒感染的敏感度、特异度、阳性似然值分别为0.532、0.940、0.494,均优于hs-CRP和PCT。结论原发性肺癌患者发生肺部感染后血清SAA、hs-CRP、PCT指标水平变化明显,血清SAA、hs-CRP、PCT诊断细菌感染患者较病毒感染患者准确性高,临床医师可以根据血清SAA、hs-CRP、PCT检测结果对患者肺部感染情况进行初步判断。
基金supported by the National Natural Science Foundation of China (Grant No. 30870578)the National Basic Research Program of China (Grant No. 2006CB500700)funded by the US National Institutes of Health for providing nematode strains used in this work
文摘β-amyloid (Aβ) and copper play important roles in the pathogenesis of Alzheimer’s disease (AD).However,the behavioral correlativity and molecular mechanisms of Aβ and copper toxicity have been investigated less often.In the present study,we investigated the interaction and toxicity of Aβ1-42 and copper in the Aβ1-42 transgenic Caenorhabditis elegans worm model CL2006.Our data show that the paralysis behavior of CL2006 worms significantly deteriorated after exposure to 10-3 mol L-1 copper ions.However,the paralysis behavior was dramatically attenuated with exposure to 10-4 mol L-1 copper ions.The exogenous copper treatment also partially changed the homeostatic balance of zinc,manganese,and iron.Our data suggest that the accumulation of reactive oxygen species (ROS) was responsible for the paralysis induced by Aβ and copper in CL2006.The ROS generation induced by Aβ and copper appear to be through sod-1,prdx-2,skn-1,hsp-60 and hsp-16.2 genes.
