The complex 3D flow in a steam turbine exhaust hood model with different inlet swirl and inlet total pressure radial distributions has been simulated by employing CFX-5 and analyzed in this paper. It＇s found that the...The complex 3D flow in a steam turbine exhaust hood model with different inlet swirl and inlet total pressure radial distributions has been simulated by employing CFX-5 and analyzed in this paper. It＇s found that the inlet tangential flow angle at hub has a negative effect on the exhaust hood performance, while a negative gradient of inlet total pressure radial distribution has a positive impact on the hood performances. It＇s also numerically con- firmed that a proper distribution of total pressure at hood inlet can successfully eliminate the negative effects caused by the inappropriate inlet swirl distribution and improve the hood aerodynamic performance.展开更多
AIM: To investigate the protective effect of ischemic preconditioning (IPC) on hepatocellular carcinoma (HCC) patients with cirrhosis undergoing hepatic resection under hepatic inflow occlusion (HIO) and its possible ...AIM: To investigate the protective effect of ischemic preconditioning (IPC) on hepatocellular carcinoma (HCC) patients with cirrhosis undergoing hepatic resection under hepatic inflow occlusion (HIO) and its possible mechanism.METHODS: Twenty-nine consecutive patients with resectable OHCC were randomized into two groups: IPC group: before HIO, IPC with 5 min of ischemia and 5 min of reperfusion was given; control group: no IPC was given. Uver functions,hepatic Caspase-3 activity, and apoptotic cells were compared between these two groups.RESULTS: On postoperative days (POD) 1, 3 and 7, the aspartate transaminase (AST) and alanine transaminase (ALT) levels in the IPC group were significantly lower than those in the control group (P<0.05). On POD 3 and 7, the total bilirubin level in the IPC group was significantly lower than that in the control group (P<0.05). On POD 1, the albumin level in the IPC group was higher than that in the control group (P = 0.053). After 1 h of reperfusion, both hepatic Caspase-3 activity and apoptotic sinusoidal endothelial cells in the IPC group were significantly lower than those in the control group (P<0.05).CONCLUSION: IPC has a potential protective effect on HCC patients with cirrhosis. Its protective mechanism underlying the suppression of sinusoidal endothelial cell apoptosis is achieved by inhibiting Caspase-3 activity.展开更多
基金the National Natural Science Foundation of China (grant No.50336050)
文摘The complex 3D flow in a steam turbine exhaust hood model with different inlet swirl and inlet total pressure radial distributions has been simulated by employing CFX-5 and analyzed in this paper. It＇s found that the inlet tangential flow angle at hub has a negative effect on the exhaust hood performance, while a negative gradient of inlet total pressure radial distribution has a positive impact on the hood performances. It＇s also numerically con- firmed that a proper distribution of total pressure at hood inlet can successfully eliminate the negative effects caused by the inappropriate inlet swirl distribution and improve the hood aerodynamic performance.
文摘AIM: To investigate the protective effect of ischemic preconditioning (IPC) on hepatocellular carcinoma (HCC) patients with cirrhosis undergoing hepatic resection under hepatic inflow occlusion (HIO) and its possible mechanism.METHODS: Twenty-nine consecutive patients with resectable OHCC were randomized into two groups: IPC group: before HIO, IPC with 5 min of ischemia and 5 min of reperfusion was given; control group: no IPC was given. Uver functions,hepatic Caspase-3 activity, and apoptotic cells were compared between these two groups.RESULTS: On postoperative days (POD) 1, 3 and 7, the aspartate transaminase (AST) and alanine transaminase (ALT) levels in the IPC group were significantly lower than those in the control group (P<0.05). On POD 3 and 7, the total bilirubin level in the IPC group was significantly lower than that in the control group (P<0.05). On POD 1, the albumin level in the IPC group was higher than that in the control group (P = 0.053). After 1 h of reperfusion, both hepatic Caspase-3 activity and apoptotic sinusoidal endothelial cells in the IPC group were significantly lower than those in the control group (P<0.05).CONCLUSION: IPC has a potential protective effect on HCC patients with cirrhosis. Its protective mechanism underlying the suppression of sinusoidal endothelial cell apoptosis is achieved by inhibiting Caspase-3 activity.
