Objective: The purpose of this study was to assess the percentage of hypertensive disease in pregnancies complicated by systemic lupus erythematosus at a single institution. Study design: We conducted a retrospective ...Objective: The purpose of this study was to assess the percentage of hypertensive disease in pregnancies complicated by systemic lupus erythematosus at a single institution. Study design: We conducted a retrospective analysis of medical records between 1992 and 2003 of 68 pregnancies that were complicated by systemic lupus erythematosus from 48 parturients. Patients were categorized into 3 groups: no chronic hypertension (n = 49 women), chronic hypertension-no medication (n = 6 women) and chronic hypertension-treated (n = 13 women). Analyses of variance (with Tukey-Kramer adjusted follow-up evaluation) and chi-squared/Fisher’s exact tests were used for the analyses of continuous and categoric variables, respectively. Significance was defined by a probability value of ≤.05. Results: Chronic hypertension complicated 28%of systemic lupus erythematosus pregnancies. Mean systolic blood pressures at intake were significantly different between the normotensive and no chronic hypertension groups and between the chronic hypertension-no medication and chronic hypertensiontreated groups; the differences in diastolic pressures reached significance only between the no chronic hypertension and the chronic hypertension-treated groups. Maternal age, gestational age at delivery, birth weight, lowest platelet count, and highest serum creatinine levels were similar between the hypertensive and the nonhypertensive groups. There were no differences in the percentage of aspirin or heparin treatments among the groups, but the percentage of the chronic hypertension-treated group who received steroids was significantly greater than the percentage of women who received steroids in the other 2 groups (P < .05). Preeclampsia developed in 23%of the no chronic hypertension pregnancies and in 32%of the hypertensive pregnancies (P = .54). When pregnancies that were treated with prednisone (n = 34 pregnancies)were comparedwith those pregnancies that were managed with other agents (n = 34 pregnancies), the percentages of preeclam-psia were si展开更多
纯红细胞再生障碍性贫血(pure red cel aplasia PRCA)是指骨髓单纯红细胞牛成障碍的一类贫血。为了探讨治疗PRCA的有效方法,我们采用环孢菌素A(CsA)联合泼尼松对纯红再障患者进行治疗,取得了一定的疗效,现将结果报道如下。 1资料与方法 ...纯红细胞再生障碍性贫血(pure red cel aplasia PRCA)是指骨髓单纯红细胞牛成障碍的一类贫血。为了探讨治疗PRCA的有效方法,我们采用环孢菌素A(CsA)联合泼尼松对纯红再障患者进行治疗,取得了一定的疗效,现将结果报道如下。 1资料与方法 1.1一般资料本组8例PRCA患者均为2010年1月~2014年2月我科收治入院的患者。所有患者均符合符合全国统一诊断标准[1],均经血常规、骨髓象或合并骨髓活检确诊,均为继发性PRCA。其中男性患者5例,女性患者3例;年龄39~74岁,平均年龄(51.8依8.9)岁。所有患者均呈重度贫血,但无肝、脾肿大及明显出血症状。展开更多
文摘Objective: The purpose of this study was to assess the percentage of hypertensive disease in pregnancies complicated by systemic lupus erythematosus at a single institution. Study design: We conducted a retrospective analysis of medical records between 1992 and 2003 of 68 pregnancies that were complicated by systemic lupus erythematosus from 48 parturients. Patients were categorized into 3 groups: no chronic hypertension (n = 49 women), chronic hypertension-no medication (n = 6 women) and chronic hypertension-treated (n = 13 women). Analyses of variance (with Tukey-Kramer adjusted follow-up evaluation) and chi-squared/Fisher’s exact tests were used for the analyses of continuous and categoric variables, respectively. Significance was defined by a probability value of ≤.05. Results: Chronic hypertension complicated 28%of systemic lupus erythematosus pregnancies. Mean systolic blood pressures at intake were significantly different between the normotensive and no chronic hypertension groups and between the chronic hypertension-no medication and chronic hypertensiontreated groups; the differences in diastolic pressures reached significance only between the no chronic hypertension and the chronic hypertension-treated groups. Maternal age, gestational age at delivery, birth weight, lowest platelet count, and highest serum creatinine levels were similar between the hypertensive and the nonhypertensive groups. There were no differences in the percentage of aspirin or heparin treatments among the groups, but the percentage of the chronic hypertension-treated group who received steroids was significantly greater than the percentage of women who received steroids in the other 2 groups (P < .05). Preeclampsia developed in 23%of the no chronic hypertension pregnancies and in 32%of the hypertensive pregnancies (P = .54). When pregnancies that were treated with prednisone (n = 34 pregnancies)were comparedwith those pregnancies that were managed with other agents (n = 34 pregnancies), the percentages of preeclam-psia were si
文摘纯红细胞再生障碍性贫血(pure red cel aplasia PRCA)是指骨髓单纯红细胞牛成障碍的一类贫血。为了探讨治疗PRCA的有效方法,我们采用环孢菌素A(CsA)联合泼尼松对纯红再障患者进行治疗,取得了一定的疗效,现将结果报道如下。 1资料与方法 1.1一般资料本组8例PRCA患者均为2010年1月~2014年2月我科收治入院的患者。所有患者均符合符合全国统一诊断标准[1],均经血常规、骨髓象或合并骨髓活检确诊,均为继发性PRCA。其中男性患者5例,女性患者3例;年龄39~74岁,平均年龄(51.8依8.9)岁。所有患者均呈重度贫血,但无肝、脾肿大及明显出血症状。
