Indium tin oxide (ITO) nanoparticles were synthesized by precipitation method from granulated indium and oxalate tin. The ITO particles were characterized by means of XRD, BET and TEM. The tin doping decreases the cry...Indium tin oxide (ITO) nanoparticles were synthesized by precipitation method from granulated indium and oxalate tin. The ITO particles were characterized by means of XRD, BET and TEM. The tin doping decreases the crystallite size, increases the specific surface area and decreases the lattice volume of the ITO nanoparticles. The absence of chlorine ions in the synthesis greatly increases the particles′ purity, decreases the agglomeration and improves the synthesis efficiency. This synthesis process to ITO nanoparticles is now in pilot-scale production in: Light & Future Advanced Material Co. LTD, Daegu, Korea.展开更多
Hydroxyapatite(HA) nanoparticles were prepared by coprecipitation-hydrothermal synthesis and their exosyndrome was estimated via transmission electron microscopy. Agarose gel electrophoresis and ultraviolet spectropho...Hydroxyapatite(HA) nanoparticles were prepared by coprecipitation-hydrothermal synthesis and their exosyndrome was estimated via transmission electron microscopy. Agarose gel electrophoresis and ultraviolet spectrophotometry were used to evaluate the ability of HA to bind NR2B-siRNA at different pH values and at different HA-NR2B-siRNA ratios. And the stability of the complex in saline was also evaluated. The effect of HA/NR2B-siRNA complex on chronic inflammatory pain was evaluated in vivo in mice. Transmission electron microscopy(TEM) reveals that HA nanoparticles are thin strips or short rod in shape and the one-dimensional particle size of HA nanoparticles is 40-50 nm. Under the acid or neutral condition, the Zeta potential of HA is positive; nanoparticles can completely bind NR2B-siRNA when the HA:NR2B-siRNA ratio is at or larger than 35-1; while under the alkaline condition, the affinity of HA to NR2B-siRNA is rather weak. HA/NR2B-siRNA complex is not dissociated when being resuspended in saline. The nociception of the tonic phase induced by formalin is significantly reduced in the HA/NR2B-siRNA treated mice as compared with the controls. Therefore, HA may be a new siRNA nano-vector material.展开更多
文摘Indium tin oxide (ITO) nanoparticles were synthesized by precipitation method from granulated indium and oxalate tin. The ITO particles were characterized by means of XRD, BET and TEM. The tin doping decreases the crystallite size, increases the specific surface area and decreases the lattice volume of the ITO nanoparticles. The absence of chlorine ions in the synthesis greatly increases the particles′ purity, decreases the agglomeration and improves the synthesis efficiency. This synthesis process to ITO nanoparticles is now in pilot-scale production in: Light & Future Advanced Material Co. LTD, Daegu, Korea.
基金Project(07JJ5035)supported by the Natural Science Foundation of Hunan Province,ChinaProject(2007WK3031)supported by Science and Technology Foundation of Hunan Province,China
文摘Hydroxyapatite(HA) nanoparticles were prepared by coprecipitation-hydrothermal synthesis and their exosyndrome was estimated via transmission electron microscopy. Agarose gel electrophoresis and ultraviolet spectrophotometry were used to evaluate the ability of HA to bind NR2B-siRNA at different pH values and at different HA-NR2B-siRNA ratios. And the stability of the complex in saline was also evaluated. The effect of HA/NR2B-siRNA complex on chronic inflammatory pain was evaluated in vivo in mice. Transmission electron microscopy(TEM) reveals that HA nanoparticles are thin strips or short rod in shape and the one-dimensional particle size of HA nanoparticles is 40-50 nm. Under the acid or neutral condition, the Zeta potential of HA is positive; nanoparticles can completely bind NR2B-siRNA when the HA:NR2B-siRNA ratio is at or larger than 35-1; while under the alkaline condition, the affinity of HA to NR2B-siRNA is rather weak. HA/NR2B-siRNA complex is not dissociated when being resuspended in saline. The nociception of the tonic phase induced by formalin is significantly reduced in the HA/NR2B-siRNA treated mice as compared with the controls. Therefore, HA may be a new siRNA nano-vector material.
