AIM: To understand the relationship between the migration of NSC and the expression of bFGF after permanent cerebral ischemia. METHODS: Choosing rats with permanent cerebral ischemia as models and adopting immunohisto...AIM: To understand the relationship between the migration of NSC and the expression of bFGF after permanent cerebral ischemia. METHODS: Choosing rats with permanent cerebral ischemia as models and adopting immunohistochemical staining to observe the migration of NSC in the state of cerebral ischemia and the expression of bFGF protein. RESULTS: There was a migration pattern with time space accordance between NSCs and bFGF + cells which migrated from SEZ towards ischemic cerebral tissue along ventral side of corpus callosum, and the intense bFGF protein expression in the corpus callosum after ischemia. Many bFGF + cells were found within and near the ischemic tissue after long time ischemia. CONCLUSION: The migration of NSCs from SEZ to ischemic area might need the sustenance of bFGF protein.展开更多
2020年8月12日,《自噬》(Autophagy)在线发表了陈忠教授、张翔南教授团队的最新研究成果“BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains”(https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1...2020年8月12日,《自噬》(Autophagy)在线发表了陈忠教授、张翔南教授团队的最新研究成果“BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains”(https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1802089)。展开更多
目的:探讨白藜芦醇对小鼠永久性局灶脑缺血后血脑屏障损伤的影响.方法:采用线段血管内栓塞大脑中动脉(MCAO)获得小鼠脑缺血模型,静脉注射Evans b lue,观察白藜芦醇对缺血24 h后脑组织中Evans b lue外渗范围和含量的影响,同时应用RT-PCR...目的:探讨白藜芦醇对小鼠永久性局灶脑缺血后血脑屏障损伤的影响.方法:采用线段血管内栓塞大脑中动脉(MCAO)获得小鼠脑缺血模型,静脉注射Evans b lue,观察白藜芦醇对缺血24 h后脑组织中Evans b lue外渗范围和含量的影响,同时应用RT-PCR技术检测缺血脑组织中基质金属蛋白酶-9(MMP-9)的mRNA水平.结果:白藜芦醇减轻了Evans b lue外渗范围[(101±15)mm3vs(149±17)mm3,P<0.01]和含量[(8.6±2.9)%vs(18.6±3.8)%,P<0.01],并能够抑制MMP-9的表达[(0.693±0.008)vs(1.537±0.037),P<0.01].结论:白藜芦醇可以抑制MMP-9活性,减轻血脑屏障的损害,其神经保护作用与此有关.展开更多
文摘AIM: To understand the relationship between the migration of NSC and the expression of bFGF after permanent cerebral ischemia. METHODS: Choosing rats with permanent cerebral ischemia as models and adopting immunohistochemical staining to observe the migration of NSC in the state of cerebral ischemia and the expression of bFGF protein. RESULTS: There was a migration pattern with time space accordance between NSCs and bFGF + cells which migrated from SEZ towards ischemic cerebral tissue along ventral side of corpus callosum, and the intense bFGF protein expression in the corpus callosum after ischemia. Many bFGF + cells were found within and near the ischemic tissue after long time ischemia. CONCLUSION: The migration of NSCs from SEZ to ischemic area might need the sustenance of bFGF protein.
文摘2020年8月12日,《自噬》(Autophagy)在线发表了陈忠教授、张翔南教授团队的最新研究成果“BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains”(https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1802089)。
文摘目的:探讨白藜芦醇对小鼠永久性局灶脑缺血后血脑屏障损伤的影响.方法:采用线段血管内栓塞大脑中动脉(MCAO)获得小鼠脑缺血模型,静脉注射Evans b lue,观察白藜芦醇对缺血24 h后脑组织中Evans b lue外渗范围和含量的影响,同时应用RT-PCR技术检测缺血脑组织中基质金属蛋白酶-9(MMP-9)的mRNA水平.结果:白藜芦醇减轻了Evans b lue外渗范围[(101±15)mm3vs(149±17)mm3,P<0.01]和含量[(8.6±2.9)%vs(18.6±3.8)%,P<0.01],并能够抑制MMP-9的表达[(0.693±0.008)vs(1.537±0.037),P<0.01].结论:白藜芦醇可以抑制MMP-9活性,减轻血脑屏障的损害,其神经保护作用与此有关.
