Objective The purpose of this study was to compare patient satisfacti on with t he topical immune system modulator tacrolimus to topical clobetasol during treat ment for vulvovaginal erosive lichen planus. Study desig...Objective The purpose of this study was to compare patient satisfacti on with t he topical immune system modulator tacrolimus to topical clobetasol during treat ment for vulvovaginal erosive lichen planus. Study design Subjects who had been diagnosed with vulvovaginal erosive lichen planus between June 2000 a nd May 2001 received a mail survey regarding clinical satisfaction and response to treatment with clobetasol and tacrolimus. Satisfaction was assessed with a 10 0-mm visual analogue scale (very unsatisfied, 0; very satisfied, 100). Satisfac tion was compared with the use of a paired t-test. Results Nineteen subjects me t the inclusion criteria; 17 subjects (89%) returned completed surveys. Sixteen of the 17 women reported clobetasol therapy, and 11 of the 17 subjects acknowle dged the use of tacrolimus therapy. All but 1 of the women who received tacrolim us had been treated previously with clobetasol therapy. All subjects reported ex periencing sexual pain before their initial examination. After treatment with cl obetasol, 2 of 16 women reported pain-free intercourse. Two additional women re ported pain-free intercourse after switching to tacrolimus therapy. Ten subject s who had used both treatments rated tacrolimus therapy as significantly more sa tisfactory than clobetasol therapy (63 vs 38 mm; P=.03). Conclusion The use of t opical tacrolimus improves satisfaction and may result in better clinical outcom es than therapy with clobetasol for the treatment of vulvovaginal erosive lichen planus.展开更多
文摘Objective The purpose of this study was to compare patient satisfacti on with t he topical immune system modulator tacrolimus to topical clobetasol during treat ment for vulvovaginal erosive lichen planus. Study design Subjects who had been diagnosed with vulvovaginal erosive lichen planus between June 2000 a nd May 2001 received a mail survey regarding clinical satisfaction and response to treatment with clobetasol and tacrolimus. Satisfaction was assessed with a 10 0-mm visual analogue scale (very unsatisfied, 0; very satisfied, 100). Satisfac tion was compared with the use of a paired t-test. Results Nineteen subjects me t the inclusion criteria; 17 subjects (89%) returned completed surveys. Sixteen of the 17 women reported clobetasol therapy, and 11 of the 17 subjects acknowle dged the use of tacrolimus therapy. All but 1 of the women who received tacrolim us had been treated previously with clobetasol therapy. All subjects reported ex periencing sexual pain before their initial examination. After treatment with cl obetasol, 2 of 16 women reported pain-free intercourse. Two additional women re ported pain-free intercourse after switching to tacrolimus therapy. Ten subject s who had used both treatments rated tacrolimus therapy as significantly more sa tisfactory than clobetasol therapy (63 vs 38 mm; P=.03). Conclusion The use of t opical tacrolimus improves satisfaction and may result in better clinical outcom es than therapy with clobetasol for the treatment of vulvovaginal erosive lichen planus.
