Wound healing has invariably been a fundamental health concern,demanding manpower and materials and causing financial burdens.In this research,inspired by the hemostatic function of platelets,we proposed a novel bioni...Wound healing has invariably been a fundamental health concern,demanding manpower and materials and causing financial burdens.In this research,inspired by the hemostatic function of platelets,we proposed a novel bionic hydrogel by covalent amidation crosslinking natural platelet and alginate for wound healing.With the natural functional groups,the platelet-derived hydrogel exhibited outstanding biocompatibility and blood compatibility.By changing the addition ratio of platelets to alginates,the mechanical properties of the achieved hydrogel were variable to cater to different wound environments.Furthermore,silver nanoparticles could be loaded into the void space of the hydrogel which endowed the composites with superior anti-infective properties.We have demonstrated that the bio-inspired platelet hydrogel could promote hemostasis of acute tissue damage,prevent bacterial proliferation,and promote angiogenesis,collagen deposition,and granulation tissue formation in wound healing.These features signify the potential values of the bio-inspired platelet hydrogel in clinical applications.展开更多
经外周静脉置入中心静脉导管（peripherally inserted central catheter,PICC）指从外周静脉置入,将导管尖端置于上腔静脉的方法。目前已广泛应用于需长期输液及肿瘤化疗的患者。PICC置管后常规需在24h内行首次换药[1],更换压迫在穿刺...经外周静脉置入中心静脉导管（peripherally inserted central catheter,PICC）指从外周静脉置入,将导管尖端置于上腔静脉的方法。目前已广泛应用于需长期输液及肿瘤化疗的患者。PICC置管后常规需在24h内行首次换药[1],更换压迫在穿刺点处的小方纱。展开更多
基金supported by the National Key Research and Development Program of China(2020YFA0908200)the National Natural Science Foundation of China(52073060 and 22002061)+1 种基金the Natural Science Foundation of Jiangsu(BK20200551)the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038)。
文摘Wound healing has invariably been a fundamental health concern,demanding manpower and materials and causing financial burdens.In this research,inspired by the hemostatic function of platelets,we proposed a novel bionic hydrogel by covalent amidation crosslinking natural platelet and alginate for wound healing.With the natural functional groups,the platelet-derived hydrogel exhibited outstanding biocompatibility and blood compatibility.By changing the addition ratio of platelets to alginates,the mechanical properties of the achieved hydrogel were variable to cater to different wound environments.Furthermore,silver nanoparticles could be loaded into the void space of the hydrogel which endowed the composites with superior anti-infective properties.We have demonstrated that the bio-inspired platelet hydrogel could promote hemostasis of acute tissue damage,prevent bacterial proliferation,and promote angiogenesis,collagen deposition,and granulation tissue formation in wound healing.These features signify the potential values of the bio-inspired platelet hydrogel in clinical applications.
