This study investigated the alleviating effects of hydrogen sulfide （H2S）, derived from sodium hydrosulfide （NariS）, on inflammation induced by dextran sulfate sodium （DSS） in both in vivo and in vitro models. W...This study investigated the alleviating effects of hydrogen sulfide （H2S）, derived from sodium hydrosulfide （NariS）, on inflammation induced by dextran sulfate sodium （DSS） in both in vivo and in vitro models. We found that NariS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NariS （20 pmol/L） reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H2S. It was also found that H2S may regulate cytokine expression by inhibiting the nuclear factor-KB （NF-KB） signaling pathway. In conclusion, our results demon- strated that H2S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-KB signaling pathway.展开更多
文摘This study investigated the alleviating effects of hydrogen sulfide （H2S）, derived from sodium hydrosulfide （NariS）, on inflammation induced by dextran sulfate sodium （DSS） in both in vivo and in vitro models. We found that NariS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NariS （20 pmol/L） reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H2S. It was also found that H2S may regulate cytokine expression by inhibiting the nuclear factor-KB （NF-KB） signaling pathway. In conclusion, our results demon- strated that H2S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-KB signaling pathway.
