OBJECTIVE:To evaluate the curative effect of external application of the Chinese drug,Sanjierupi Gao,on mastalgia caused by mammary gland hyperplasia.METHODS:This randomized,double-blinded,and placebo controlled study...OBJECTIVE:To evaluate the curative effect of external application of the Chinese drug,Sanjierupi Gao,on mastalgia caused by mammary gland hyperplasia.METHODS:This randomized,double-blinded,and placebo controlled study enrolled 260 patients with mammary gland hyperplasia from five hospitals.Patients were randomly and equally divided in-to a Sanjierupi Gao treatment group and a placebo control group.An adhesive plaster was applied to the most painful area on either breast for 7 h a day.Treatment lasted for two menstrual cycles without application during menstruation.Mastalgia was used as the main index of curative effect.The change before and after treatment in days of mastalgia,the time to alleviate pain,pain extent,and severe pain scores were observed.RESULTS:Compared to the control group,the treatment group had significantly fewer days of mastalgia(P<0.01),a significantly lower severe pain score(P<0.01),and significantly less subjective pain and tenderness(P<0.05 and P<0.01,respectively).Three days before the follow-up visit,the pain score in the treatment group was significantly lower than that in the control group(P<0.05).A non-parametric test was used to compare the time to alleviate mastalgia between the two groups and found no statistical difference(Z=0.313,P=0.754).CONCLUSION:Application of Sanjierupi Gao can decrease mastalgia duration in patients with mammary gland hyperplasia during menstruation and alleviate the extent of mastalgia.The time to alleviate pain is psychologically influenced.展开更多
既往文献报道,有7%~10%的育龄期女性患有不孕症,其中排卵障碍是不孕症的主要原因之一,其发生率约占全部不孕症的25%~35%,而85%的排卵障碍患者为世界卫生组织(World Health Organization,WHO) Ⅱ型排卵障碍,严重困扰育龄期患者的家庭婚...既往文献报道,有7%~10%的育龄期女性患有不孕症,其中排卵障碍是不孕症的主要原因之一,其发生率约占全部不孕症的25%~35%,而85%的排卵障碍患者为世界卫生组织(World Health Organization,WHO) Ⅱ型排卵障碍,严重困扰育龄期患者的家庭婚姻生活和身心健康[1]。WHO Ⅱ型排卵障碍是指促性腺激素和雌激素正常的无排卵,以多囊卵巢综合征最为常见,发病机制复杂,涉及遗传、代谢、内分泌等多种因素所致代谢紊乱,病因有待明确[2]。展开更多
基金Supported by a Demonstrative Project of Research into Specific Therapy and Technology of External Application in Traditional Chinese MedicineNational Sci-Tech Plan of the Ministry of Science and Technology in the 11th 5-Year Plan(2008BAI53B053)
文摘OBJECTIVE:To evaluate the curative effect of external application of the Chinese drug,Sanjierupi Gao,on mastalgia caused by mammary gland hyperplasia.METHODS:This randomized,double-blinded,and placebo controlled study enrolled 260 patients with mammary gland hyperplasia from five hospitals.Patients were randomly and equally divided in-to a Sanjierupi Gao treatment group and a placebo control group.An adhesive plaster was applied to the most painful area on either breast for 7 h a day.Treatment lasted for two menstrual cycles without application during menstruation.Mastalgia was used as the main index of curative effect.The change before and after treatment in days of mastalgia,the time to alleviate pain,pain extent,and severe pain scores were observed.RESULTS:Compared to the control group,the treatment group had significantly fewer days of mastalgia(P<0.01),a significantly lower severe pain score(P<0.01),and significantly less subjective pain and tenderness(P<0.05 and P<0.01,respectively).Three days before the follow-up visit,the pain score in the treatment group was significantly lower than that in the control group(P<0.05).A non-parametric test was used to compare the time to alleviate mastalgia between the two groups and found no statistical difference(Z=0.313,P=0.754).CONCLUSION:Application of Sanjierupi Gao can decrease mastalgia duration in patients with mammary gland hyperplasia during menstruation and alleviate the extent of mastalgia.The time to alleviate pain is psychologically influenced.
文摘既往文献报道,有7%~10%的育龄期女性患有不孕症,其中排卵障碍是不孕症的主要原因之一,其发生率约占全部不孕症的25%~35%,而85%的排卵障碍患者为世界卫生组织(World Health Organization,WHO) Ⅱ型排卵障碍,严重困扰育龄期患者的家庭婚姻生活和身心健康[1]。WHO Ⅱ型排卵障碍是指促性腺激素和雌激素正常的无排卵,以多囊卵巢综合征最为常见,发病机制复杂,涉及遗传、代谢、内分泌等多种因素所致代谢紊乱,病因有待明确[2]。
