Objective To evaluate the efficacy of rabbit lens capsular bag by using 5-fluorouracil(5-FU) in combination with mitomycin C (MMC) in preventing posterior capsule opacification (PCO) and its mechanism. Methods Forty N...Objective To evaluate the efficacy of rabbit lens capsular bag by using 5-fluorouracil(5-FU) in combination with mitomycin C (MMC) in preventing posterior capsule opacification (PCO) and its mechanism. Methods Forty New Zealand rabbits (80 eyes) received continuous curvilinear capsulorhexis (CCC,its diameter approximately 3 millimete) and phacoemulsification,and were randomly divided into 2 groups:The right eyes of the rabbits lens capsular bags of the experimental group (twenty New Zealand rabbits)were in jected with methylcellulose (MC) contained 12.5 mg/ml 5-FU and 0.2mg/ml MMC,and the left eyes of that were injected with only MC as vacuity control group;While the right eyes of the rabbits lens capsular bags of the control group (twenty New Zealand rabbits) were injected with methylcellulose (MC) contained 0.2mg/ml MMC,and the left eyes of that were in jected with MC contained 12.5 mg/ml 5-FU.The anterior chamber of all subjects were filled with sodium hyaluronate (HA).Five minuts late,the anterior chambers and lens capsular bags of all subjects were permutated by irrigating solution.Some of the subjects were implantated intraocular lens (IOL) in lens capsular bags.In the two-month to twenty-month follow-up after the operation,all eyes were examined by slit-lamp microscopy,the PCO were observed and compared between the two groups;the histopathologic examination of the lens capsule membran and IOL,the wholemount technique of the lens capsule membran,the electron microscope inspection of the IOL were also observed in different period. Results For clinical study,the PCO appeared in the vacuity control group two weeks after the operation.Some of the psuedophakic subject were formed frontal membrane of the IOL.The longer follow-up after the operation,the stronger PCO were taken place.The PCO did not appeare any more in the experimental group twenty-month follow-up after the operation,while the control group appeare somewhat of a PCO.The histopathologic examination showed that the proliferation of lens epithelial ce展开更多
目的探讨晶状体囊袋张力环（CTR）完全脱位的治疗效果。设计回顾性病例系列。研究对象2006年3月至2010年2月北京同仁医院治疗的CTR完全脱位患者11例（11眼）。方法所有患者先行玻璃体切除联合脱位CTR取出,再根据视网膜和视盘情况以及取...目的探讨晶状体囊袋张力环（CTR）完全脱位的治疗效果。设计回顾性病例系列。研究对象2006年3月至2010年2月北京同仁医院治疗的CTR完全脱位患者11例（11眼）。方法所有患者先行玻璃体切除联合脱位CTR取出,再根据视网膜和视盘情况以及取出的CTR和人工晶状体（IOL）状况,分别选择IOL或CTR缝线固定7眼,虹膜固定型IOL植入1眼,硅油填充3眼。术后随访5~32个月。主要指标视力、眼压、IOL居中性及并发症。结果 11眼均顺利取出脱位的CTR和IOL,8眼同时植入IOL,3眼行硅油填充。最后一次随访时最佳矫正视力0.3~0.6者4眼,0.1~0.2者4眼,低于0.1者2眼,1例患者不合作。其中5眼达到或超过CTR脱位前的最好矫正视力。术后高眼压5眼,眼压25~51 mm Hg。4眼经药物治疗,1眼经巩膜睫状体光凝后眼压恢复正常。前房积血1眼,经药物治疗后吸收。未出现IOL或IOL-CTR复合体脱位或偏位现象。结论玻璃体切除联合脱位CTR取出并睫状沟缝线固定IOL或CTR可以有效地治疗CTR完全脱位。展开更多
文摘Objective To evaluate the efficacy of rabbit lens capsular bag by using 5-fluorouracil(5-FU) in combination with mitomycin C (MMC) in preventing posterior capsule opacification (PCO) and its mechanism. Methods Forty New Zealand rabbits (80 eyes) received continuous curvilinear capsulorhexis (CCC,its diameter approximately 3 millimete) and phacoemulsification,and were randomly divided into 2 groups:The right eyes of the rabbits lens capsular bags of the experimental group (twenty New Zealand rabbits)were in jected with methylcellulose (MC) contained 12.5 mg/ml 5-FU and 0.2mg/ml MMC,and the left eyes of that were injected with only MC as vacuity control group;While the right eyes of the rabbits lens capsular bags of the control group (twenty New Zealand rabbits) were injected with methylcellulose (MC) contained 0.2mg/ml MMC,and the left eyes of that were in jected with MC contained 12.5 mg/ml 5-FU.The anterior chamber of all subjects were filled with sodium hyaluronate (HA).Five minuts late,the anterior chambers and lens capsular bags of all subjects were permutated by irrigating solution.Some of the subjects were implantated intraocular lens (IOL) in lens capsular bags.In the two-month to twenty-month follow-up after the operation,all eyes were examined by slit-lamp microscopy,the PCO were observed and compared between the two groups;the histopathologic examination of the lens capsule membran and IOL,the wholemount technique of the lens capsule membran,the electron microscope inspection of the IOL were also observed in different period. Results For clinical study,the PCO appeared in the vacuity control group two weeks after the operation.Some of the psuedophakic subject were formed frontal membrane of the IOL.The longer follow-up after the operation,the stronger PCO were taken place.The PCO did not appeare any more in the experimental group twenty-month follow-up after the operation,while the control group appeare somewhat of a PCO.The histopathologic examination showed that the proliferation of lens epithelial ce
文摘目的探讨晶状体囊袋张力环（CTR）完全脱位的治疗效果。设计回顾性病例系列。研究对象2006年3月至2010年2月北京同仁医院治疗的CTR完全脱位患者11例（11眼）。方法所有患者先行玻璃体切除联合脱位CTR取出,再根据视网膜和视盘情况以及取出的CTR和人工晶状体（IOL）状况,分别选择IOL或CTR缝线固定7眼,虹膜固定型IOL植入1眼,硅油填充3眼。术后随访5~32个月。主要指标视力、眼压、IOL居中性及并发症。结果 11眼均顺利取出脱位的CTR和IOL,8眼同时植入IOL,3眼行硅油填充。最后一次随访时最佳矫正视力0.3~0.6者4眼,0.1~0.2者4眼,低于0.1者2眼,1例患者不合作。其中5眼达到或超过CTR脱位前的最好矫正视力。术后高眼压5眼,眼压25~51 mm Hg。4眼经药物治疗,1眼经巩膜睫状体光凝后眼压恢复正常。前房积血1眼,经药物治疗后吸收。未出现IOL或IOL-CTR复合体脱位或偏位现象。结论玻璃体切除联合脱位CTR取出并睫状沟缝线固定IOL或CTR可以有效地治疗CTR完全脱位。
