AIM: To compare the benefi cial effects of early enteral nutrition (EN) with prebiotic fiber supplementation in patients with severe acute pancreatitis (AP).METHODS: Thirty consecutive patients with severe AP, who req...AIM: To compare the benefi cial effects of early enteral nutrition (EN) with prebiotic fiber supplementation in patients with severe acute pancreatitis (AP).METHODS: Thirty consecutive patients with severe AP, who required stoppage of oral feeding for 48 h, were randomly assigned to nasojejunal EN with or without prebiotics. APACHE Ⅱ score, Balthazar’s CT score and CRP were assessed daily during the study period.RESULTS: The median duration of hospital stay was shorter in the study group [10 ± 4 (8-14) d vs 15 ± 6 (7-26) d] (P < 0.05). The median value of days in intensive care unit was also similar in both groups [6 ± 2 (5-8) d vs 6 ± 2 (5-7) d]. The median duration of EN was 8 ± 4 (6-12) d vs 10 ± 4 (6-13) d in the study and control groups, respectively (P > 0.05). Deaths occurred in 6 patients (20%), 2 in the study group and 4 in the control group. The mean duration of APACHE Ⅱ normalization (APACHE Ⅱ score < 8) was shorter in the study group than in the control group (4 ± 2 d vs 6.5 ± 3 d, P < 0.05). The mean duration of CRP normalization was also shorter in the study group than in the control group (7 ± 2 d vs 10 ± 3 d, P < 0.05).CONCLUSION: Nasojejunal EN with prebiotic fiber supplementation in severe AP improves hospital stay, duration nutrition therapy, acute phase response and overall complications compared to standard EN therapy.展开更多
早期肠内营养(EEN)定义为患者住院后48 h内启动的肠内营养(EN),无关乎其剂量与类型。最近欧洲危重病学会(ESICM)聚焦成年重症患者经常被延迟肠内营养(DEN)的24种特殊临床情况,通过循证医学方法比较EEN与早期肠外营养及DEN的利弊,提出7...早期肠内营养(EEN)定义为患者住院后48 h内启动的肠内营养(EN),无关乎其剂量与类型。最近欧洲危重病学会(ESICM)聚焦成年重症患者经常被延迟肠内营养(DEN)的24种特殊临床情况,通过循证医学方法比较EEN与早期肠外营养及DEN的利弊,提出7条利于DEN推荐建议和17条利于EEN推荐建议,制定了《重症患者早期肠内营养:ESICM临床实践指南》并于2017年3月在Intensive Care Medicine杂志上发表。本文将介绍该指南的制定背景、推荐建议与理由。展开更多
目的系统评价早期肠内营养(EEN)联合微生态制剂治疗重症急性胰腺炎(SAP)的疗效与价值。方法计算机检索中国学术期刊全文数据库、中国生物医学文献数据库、万方医学网、维普中文期刊服务平台、Cochrane Library、PubMed、Embase、Web of ...目的系统评价早期肠内营养(EEN)联合微生态制剂治疗重症急性胰腺炎(SAP)的疗效与价值。方法计算机检索中国学术期刊全文数据库、中国生物医学文献数据库、万方医学网、维普中文期刊服务平台、Cochrane Library、PubMed、Embase、Web of Science,检索时间为建库起至2019年11月1日,采用荟萃分析方法比较在SAP患者中EEN联合微生态制剂(试验组)与仅采用EEN治疗(对照组)的临床疗效,包括血清C-反应蛋白水平、多器官功能障碍综合征发生率、胰腺感染坏死发生率、其他并发症的发生率、死亡率、住院时间等主要结局指标以及血浆白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α水平、胃肠道评分、外科干预的发生率等次要结局指标。由2名评价员严格按照纳入排除标准筛选文献、提取数据后采用Cochrane系统评价员手册5.1.0偏倚风险评估工具对纳入文献进行质量评价,采用Stata16.0软件进行荟萃分析。结果共纳入9项临床随机对照试验研究,762例SAP患者。荟萃分析结果显示,主要结局指标中试验组与对照组患者C反应蛋白水平[均数差(MD)=-7.58,95%可信区间(CI):-23.71~8.55]、多器官功能衰竭的发生率[对数风险比(LogRR)=-0.30,95%CI:-0.71~0.10]、胰腺感染坏死发生率(LogRR=-0.21,95%CI:-0.57~0.16)及死亡率(LogRR=0.13,95%CI:-0.36~0.62)差异均无统计学意义(P>0.05)。试验组并发症的发生率低于对照组(LogRR=-0.29,95%CI:-0.51~0.07),试验组患者住院时间(MD=-4.45,95%CI:-7.47~-1.43)较对照组时间短,差异具有统计学意义(P<0.05)。次要结局指标中试验组患者的血浆IL-8水平(MD=-7.43,95%CI:-14.28~-0.57),TNF-α水平(MD=-38.96,95%CI:-72.96~-4.95)及胃肠道评分(MD=-0.15,95%CI:-0.17~-0.13)低于对照组,差异均具有统计学意义(P<0.05),而与对照组相比外科干预的发生率(Log RR=-1.63,95%CI:-8.96~0.57)差异无统计学意义(P>0.05)。结论EEN联合微生态制剂可缩短SAP患者住院时间,降�展开更多
文摘AIM: To compare the benefi cial effects of early enteral nutrition (EN) with prebiotic fiber supplementation in patients with severe acute pancreatitis (AP).METHODS: Thirty consecutive patients with severe AP, who required stoppage of oral feeding for 48 h, were randomly assigned to nasojejunal EN with or without prebiotics. APACHE Ⅱ score, Balthazar’s CT score and CRP were assessed daily during the study period.RESULTS: The median duration of hospital stay was shorter in the study group [10 ± 4 (8-14) d vs 15 ± 6 (7-26) d] (P < 0.05). The median value of days in intensive care unit was also similar in both groups [6 ± 2 (5-8) d vs 6 ± 2 (5-7) d]. The median duration of EN was 8 ± 4 (6-12) d vs 10 ± 4 (6-13) d in the study and control groups, respectively (P > 0.05). Deaths occurred in 6 patients (20%), 2 in the study group and 4 in the control group. The mean duration of APACHE Ⅱ normalization (APACHE Ⅱ score < 8) was shorter in the study group than in the control group (4 ± 2 d vs 6.5 ± 3 d, P < 0.05). The mean duration of CRP normalization was also shorter in the study group than in the control group (7 ± 2 d vs 10 ± 3 d, P < 0.05).CONCLUSION: Nasojejunal EN with prebiotic fiber supplementation in severe AP improves hospital stay, duration nutrition therapy, acute phase response and overall complications compared to standard EN therapy.
文摘早期肠内营养(EEN)定义为患者住院后48 h内启动的肠内营养(EN),无关乎其剂量与类型。最近欧洲危重病学会(ESICM)聚焦成年重症患者经常被延迟肠内营养(DEN)的24种特殊临床情况,通过循证医学方法比较EEN与早期肠外营养及DEN的利弊,提出7条利于DEN推荐建议和17条利于EEN推荐建议,制定了《重症患者早期肠内营养:ESICM临床实践指南》并于2017年3月在Intensive Care Medicine杂志上发表。本文将介绍该指南的制定背景、推荐建议与理由。
文摘目的系统评价早期肠内营养(EEN)联合微生态制剂治疗重症急性胰腺炎(SAP)的疗效与价值。方法计算机检索中国学术期刊全文数据库、中国生物医学文献数据库、万方医学网、维普中文期刊服务平台、Cochrane Library、PubMed、Embase、Web of Science,检索时间为建库起至2019年11月1日,采用荟萃分析方法比较在SAP患者中EEN联合微生态制剂(试验组)与仅采用EEN治疗(对照组)的临床疗效,包括血清C-反应蛋白水平、多器官功能障碍综合征发生率、胰腺感染坏死发生率、其他并发症的发生率、死亡率、住院时间等主要结局指标以及血浆白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α水平、胃肠道评分、外科干预的发生率等次要结局指标。由2名评价员严格按照纳入排除标准筛选文献、提取数据后采用Cochrane系统评价员手册5.1.0偏倚风险评估工具对纳入文献进行质量评价,采用Stata16.0软件进行荟萃分析。结果共纳入9项临床随机对照试验研究,762例SAP患者。荟萃分析结果显示,主要结局指标中试验组与对照组患者C反应蛋白水平[均数差(MD)=-7.58,95%可信区间(CI):-23.71~8.55]、多器官功能衰竭的发生率[对数风险比(LogRR)=-0.30,95%CI:-0.71~0.10]、胰腺感染坏死发生率(LogRR=-0.21,95%CI:-0.57~0.16)及死亡率(LogRR=0.13,95%CI:-0.36~0.62)差异均无统计学意义(P>0.05)。试验组并发症的发生率低于对照组(LogRR=-0.29,95%CI:-0.51~0.07),试验组患者住院时间(MD=-4.45,95%CI:-7.47~-1.43)较对照组时间短,差异具有统计学意义(P<0.05)。次要结局指标中试验组患者的血浆IL-8水平(MD=-7.43,95%CI:-14.28~-0.57),TNF-α水平(MD=-38.96,95%CI:-72.96~-4.95)及胃肠道评分(MD=-0.15,95%CI:-0.17~-0.13)低于对照组,差异均具有统计学意义(P<0.05),而与对照组相比外科干预的发生率(Log RR=-1.63,95%CI:-8.96~0.57)差异无统计学意义(P>0.05)。结论EEN联合微生态制剂可缩短SAP患者住院时间,降�
