全国病毒性肝炎血清流行病学调查显示，我国成人的乙型肝炎（乙肝）发病率居高不下。成人接种乙肝疫苗有较好的免疫效果，但从流行病学角度研究乙肝疫苗接种后对人群乙肝病毒（hepatitis B virus，HBV）感染的影响，目前还少见报道。为...全国病毒性肝炎血清流行病学调查显示，我国成人的乙型肝炎（乙肝）发病率居高不下。成人接种乙肝疫苗有较好的免疫效果，但从流行病学角度研究乙肝疫苗接种后对人群乙肝病毒（hepatitis B virus，HBV）感染的影响，目前还少见报道。为切实了解实施乙肝疫苗免疫策略以来成人HBV感染状况，于2007年3—6月在无锡市开展了成人乙肝血清流行病学调查，现将有关情况报道如下。展开更多
Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and...Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated ani- mals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, FOFI ATP synthase subunit beta, and OMPI. These provide many candidate immunoreactive proteins for vaccine development.展开更多
文摘全国病毒性肝炎血清流行病学调查显示，我国成人的乙型肝炎（乙肝）发病率居高不下。成人接种乙肝疫苗有较好的免疫效果，但从流行病学角度研究乙肝疫苗接种后对人群乙肝病毒（hepatitis B virus，HBV）感染的影响，目前还少见报道。为切实了解实施乙肝疫苗免疫策略以来成人HBV感染状况，于2007年3—6月在无锡市开展了成人乙肝血清流行病学调查，现将有关情况报道如下。
基金supported by the National Basic Research Program of China (Grant No. 2010CB530200)
文摘Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated ani- mals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, FOFI ATP synthase subunit beta, and OMPI. These provide many candidate immunoreactive proteins for vaccine development.
