Dengue virus(DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spe...Dengue virus(DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever(DHF), the latter of which can progress to dengue shock syndrome(DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses. This review summarizes the current progress of studies on DHF pathogenesis, which may provide important information for achieving effective control of dengue in the future.展开更多
分化群抗原64（cluster of differentiation antigen，CD64）具有识别免疫球蛋白、高亲和IgG单体、介导体液免疫和细胞免疫及早期诊断感染性疾病IgGFc片段受体1（FcγR I）的功能，可通过抗体依赖性细胞毒和细胞吞噬及免疫复合物清除作...分化群抗原64（cluster of differentiation antigen，CD64）具有识别免疫球蛋白、高亲和IgG单体、介导体液免疫和细胞免疫及早期诊断感染性疾病IgGFc片段受体1（FcγR I）的功能，可通过抗体依赖性细胞毒和细胞吞噬及免疫复合物清除作用清除病原微生物[1]。展开更多
文摘Dengue virus(DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever(DHF), the latter of which can progress to dengue shock syndrome(DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses. This review summarizes the current progress of studies on DHF pathogenesis, which may provide important information for achieving effective control of dengue in the future.
