目的观察参附注射液强心作用的量-效关系以及不同剂量参附注射液对实验动物负荷急性增加前后心脏功能的影响。方法采用快速输液和大剂量肾上腺素注射两种方法分别制作家猫急性肺水肿和心衰模型,观察参附注射液高、低剂量对其血流动力学...目的观察参附注射液强心作用的量-效关系以及不同剂量参附注射液对实验动物负荷急性增加前后心脏功能的影响。方法采用快速输液和大剂量肾上腺素注射两种方法分别制作家猫急性肺水肿和心衰模型,观察参附注射液高、低剂量对其血流动力学改变的影响。结果参附注射液高、低剂量均能够不同程度地减缓心衰动物收缩压(SB P)和舒张压(D B P)的过度升高,以高剂量组的作用表现最强;其强心作用具有明显的量-效关系。实验中所用大剂量参附注射液对急性心衰动物的心脏功能未见不良影响。结论参附注射液强心作用强度与一次给药剂量有关;其对正常血压影响不明显。展开更多
A 4-year-old boy was hospitalized with fever for 2 days. He had no history of taking aspirin previously. Physical examination revealed a temperature of 40.2℃, pharynx congestion,enlarged tonsils and normal lungs.Lab ...A 4-year-old boy was hospitalized with fever for 2 days. He had no history of taking aspirin previously. Physical examination revealed a temperature of 40.2℃, pharynx congestion,enlarged tonsils and normal lungs.Lab findings included WBC count of 13.5x109/L with 84% neutrophils and 16% lymphocytes.The patient was diagnosed as acute tonsillitis and treated with DL-lysine aspirin 0.3g by intramuscular injection.10 minutes later,the boy developed nausea,non-projectile vomiting and dull look. It was considered the warning signs of convulsions induced by hyperpyrexia,and treated with phenobarbital 0.1g by intramuscular injection.He had shortness of breath,moist rales with bilateral lungs and 80% serum oxygen saturation.The symptoms were not lessened after giving oxygen supplement and hydrocotisone etc.2 hours later,the boy developed dyspnea,cyanosis and paleness. His conditions were deteriorated progressively after treatment including trachea intubation and mechanical ventilation.He died of respiratory and circulatory failure.展开更多
文摘目的观察参附注射液强心作用的量-效关系以及不同剂量参附注射液对实验动物负荷急性增加前后心脏功能的影响。方法采用快速输液和大剂量肾上腺素注射两种方法分别制作家猫急性肺水肿和心衰模型,观察参附注射液高、低剂量对其血流动力学改变的影响。结果参附注射液高、低剂量均能够不同程度地减缓心衰动物收缩压(SB P)和舒张压(D B P)的过度升高,以高剂量组的作用表现最强;其强心作用具有明显的量-效关系。实验中所用大剂量参附注射液对急性心衰动物的心脏功能未见不良影响。结论参附注射液强心作用强度与一次给药剂量有关;其对正常血压影响不明显。
文摘A 4-year-old boy was hospitalized with fever for 2 days. He had no history of taking aspirin previously. Physical examination revealed a temperature of 40.2℃, pharynx congestion,enlarged tonsils and normal lungs.Lab findings included WBC count of 13.5x109/L with 84% neutrophils and 16% lymphocytes.The patient was diagnosed as acute tonsillitis and treated with DL-lysine aspirin 0.3g by intramuscular injection.10 minutes later,the boy developed nausea,non-projectile vomiting and dull look. It was considered the warning signs of convulsions induced by hyperpyrexia,and treated with phenobarbital 0.1g by intramuscular injection.He had shortness of breath,moist rales with bilateral lungs and 80% serum oxygen saturation.The symptoms were not lessened after giving oxygen supplement and hydrocotisone etc.2 hours later,the boy developed dyspnea,cyanosis and paleness. His conditions were deteriorated progressively after treatment including trachea intubation and mechanical ventilation.He died of respiratory and circulatory failure.
