Survivin is a protein that is highly expressed in a vast number of malignancies,but is minimally expressed in normal tissues. It plays a role as an inhibitor of cell death in cancer cells,thus facilitating the growth ...Survivin is a protein that is highly expressed in a vast number of malignancies,but is minimally expressed in normal tissues. It plays a role as an inhibitor of cell death in cancer cells,thus facilitating the growth of these cells. In the case of gastric cancer,survivin is over-expressed in tumor cells and plays a role in the carcinogenesis process. Several studies on gastric cancer have indicated that there is a relationship between survivin expression and the ultimate behavior of the carcinoma. Since the expression pattern of survivin is selective to cancer cells,it has been described as an "ideal target" for cancer therapy. Currently,several pre-clinical and clinical trials are on-going to investigate the effects of interfering with survivin function in cancer cells as a biologic therapy. Survivin is a potentially significant protein in the diagnosis,prognosis and treatment of gastric tumors.展开更多
Objective： To assess the efficacy and safety of mouse nerve growth factor （mNGF） in patients with peripheral nerve injury. Methods： Such electronic database as Cochrane Library （Issue 1,2011）, Medline （1950-2...Objective： To assess the efficacy and safety of mouse nerve growth factor （mNGF） in patients with peripheral nerve injury. Methods： Such electronic database as Cochrane Library （Issue 1,2011）, Medline （1950-2011）, Embase （1980- 2011）, National Knowledge Infrastructure （ 1979 -2011 ） were searched and meanwhile relevant journals such as Chinese Journal of Orthopaedics, Chinese Journal of Microsurgery, Chinese Journal of Neurosurgery, ere were searched as well to collect all randomized controlled trials and quasi-randomi- zed controlled trials of mNGF on patients with peripheral nerve injury. The quality of included studies was assessed according to the criteria recommended by the Cochrane Handbook for Systematic Reviews of Interventions and the data were extracted by two reviewers independently. Meta- analysis was conducted by RevMan 5.1 software. Results： Forty-one studies involving 3 304 patients with peripheral nerve injury were included. The results of meta-analysis showed that： （1） the total effective rate ofperipheral nerve injury treatment in mNGF group was obviously higher than that in control group （OR=6.36, 95% C1 4.96-8.15, P〈0.01）; （2） the scores of activities of daily living （ADL） in mNGF group was significantly higher than that in control group （weighted mean difference=1.97, 95% CI 1.33- 2.61, P〈 0.0 l）; （3） the incidence of adverse reaction in mNGF group was higher than that in control group, （OR= 1.66, 95% CI 1.61-2.38, P=0.006）, but the adverse effects were mild, which could be relieved without specific treatment or just given symptomatic treatment, and disappeared at the end of treatment. Conclusions： The mNGF therapy is effective for peripheral nerve injury. It can obviously improve patient＇s ADL. Though the incidence of adverse reaction in mNGF treatment group is higher than that in control group, this does not influence the treatment outcomes.展开更多
文摘Survivin is a protein that is highly expressed in a vast number of malignancies,but is minimally expressed in normal tissues. It plays a role as an inhibitor of cell death in cancer cells,thus facilitating the growth of these cells. In the case of gastric cancer,survivin is over-expressed in tumor cells and plays a role in the carcinogenesis process. Several studies on gastric cancer have indicated that there is a relationship between survivin expression and the ultimate behavior of the carcinoma. Since the expression pattern of survivin is selective to cancer cells,it has been described as an "ideal target" for cancer therapy. Currently,several pre-clinical and clinical trials are on-going to investigate the effects of interfering with survivin function in cancer cells as a biologic therapy. Survivin is a potentially significant protein in the diagnosis,prognosis and treatment of gastric tumors.
文摘Objective： To assess the efficacy and safety of mouse nerve growth factor （mNGF） in patients with peripheral nerve injury. Methods： Such electronic database as Cochrane Library （Issue 1,2011）, Medline （1950-2011）, Embase （1980- 2011）, National Knowledge Infrastructure （ 1979 -2011 ） were searched and meanwhile relevant journals such as Chinese Journal of Orthopaedics, Chinese Journal of Microsurgery, Chinese Journal of Neurosurgery, ere were searched as well to collect all randomized controlled trials and quasi-randomi- zed controlled trials of mNGF on patients with peripheral nerve injury. The quality of included studies was assessed according to the criteria recommended by the Cochrane Handbook for Systematic Reviews of Interventions and the data were extracted by two reviewers independently. Meta- analysis was conducted by RevMan 5.1 software. Results： Forty-one studies involving 3 304 patients with peripheral nerve injury were included. The results of meta-analysis showed that： （1） the total effective rate ofperipheral nerve injury treatment in mNGF group was obviously higher than that in control group （OR=6.36, 95% C1 4.96-8.15, P〈0.01）; （2） the scores of activities of daily living （ADL） in mNGF group was significantly higher than that in control group （weighted mean difference=1.97, 95% CI 1.33- 2.61, P〈 0.0 l）; （3） the incidence of adverse reaction in mNGF group was higher than that in control group, （OR= 1.66, 95% CI 1.61-2.38, P=0.006）, but the adverse effects were mild, which could be relieved without specific treatment or just given symptomatic treatment, and disappeared at the end of treatment. Conclusions： The mNGF therapy is effective for peripheral nerve injury. It can obviously improve patient＇s ADL. Though the incidence of adverse reaction in mNGF treatment group is higher than that in control group, this does not influence the treatment outcomes.
