Objective To explore the ability of interictal diffusion-weighted imaging(DWI)to localize the temporal lobe of seizure origin and to predict postoperative seizure control in patients with temporal lobe epilepsy(TLE).M...Objective To explore the ability of interictal diffusion-weighted imaging(DWI)to localize the temporal lobe of seizure origin and to predict postoperative seizure control in patients with temporal lobe epilepsy(TLE).Methods Twenty-seven patients with intractable TLE considered for surgery and 19 healthy volunteers were studied with conventional magnetic resonance imaging(MRI)and DWI.Apparent diffusion coefficients(ADCs)of bilateral hippocampi in both TLE patients and control subjects were obtained.Lateralization to either temporal lobe with hippocampal ADC was based on the threshold values derived from ±1SD of right/left ratios in normal subjects.And the postoperative pathology was reviewed.Results Hippocampal ADCs were higher on the side of surgery compared with those on the contralateral side as well as the ipsilateral side in control subjects [resected side(109.8±7.3)×10-5 cm2/s,contralateral side(91.7±4.7)×10-5 cm2/s,control subjects(81.6±5.2)×10-5 cm2/s,all P<0.01].Right/left hippocampal ADC ratio and conventional MRI lateralized to the operated temporal lobe in 21 of 27(77.8%)and in 18 of 27(66.7%)patients.Lateralization to the surgical side was not associated with postoperative seizure control with right/left hippocampal ADC ratio(P>0.05).Conclusions Conventional MRI is a sensitive method to detect hippocampal sclerosis.Accuracy of the right/left hippocampal ADC ratio for lateralizing to the side of surgery is very high,but it isn't a better predictor of surgical outcome.展开更多
AIM Prostaglandin A1(PGA1) is a cyclopentenone prostaglandin. Recently, we reported that PGA1 can inhibit excitotoxin-induced apoptosis of striatal neurons in vivo and rotenone-induced apoptosis ofcultured SH-SY5Y cel...AIM Prostaglandin A1(PGA1) is a cyclopentenone prostaglandin. Recently, we reported that PGA1 can inhibit excitotoxin-induced apoptosis of striatal neurons in vivo and rotenone-induced apoptosis ofcultured SH-SY5Y cells, suggesting that PGA1 may have neuroprotective efficacy, possibly mediated by inhibition of NF-kB activation. The present study evaluated the neuroprotective potential of PGA1 and its effect on IKK/I( B/NF-kB/c-myc signaling pathway in rat models of permanent focal cerebral ischemia. METHODS Permanent middle cerebral artery occlusion (pMCAO) model was constructed by intraluminal suture cannulation through the internal carotid artery in Wistar rats.展开更多
文摘Objective To explore the ability of interictal diffusion-weighted imaging(DWI)to localize the temporal lobe of seizure origin and to predict postoperative seizure control in patients with temporal lobe epilepsy(TLE).Methods Twenty-seven patients with intractable TLE considered for surgery and 19 healthy volunteers were studied with conventional magnetic resonance imaging(MRI)and DWI.Apparent diffusion coefficients(ADCs)of bilateral hippocampi in both TLE patients and control subjects were obtained.Lateralization to either temporal lobe with hippocampal ADC was based on the threshold values derived from ±1SD of right/left ratios in normal subjects.And the postoperative pathology was reviewed.Results Hippocampal ADCs were higher on the side of surgery compared with those on the contralateral side as well as the ipsilateral side in control subjects [resected side(109.8±7.3)×10-5 cm2/s,contralateral side(91.7±4.7)×10-5 cm2/s,control subjects(81.6±5.2)×10-5 cm2/s,all P<0.01].Right/left hippocampal ADC ratio and conventional MRI lateralized to the operated temporal lobe in 21 of 27(77.8%)and in 18 of 27(66.7%)patients.Lateralization to the surgical side was not associated with postoperative seizure control with right/left hippocampal ADC ratio(P>0.05).Conclusions Conventional MRI is a sensitive method to detect hippocampal sclerosis.Accuracy of the right/left hippocampal ADC ratio for lateralizing to the side of surgery is very high,but it isn't a better predictor of surgical outcome.
文摘AIM Prostaglandin A1(PGA1) is a cyclopentenone prostaglandin. Recently, we reported that PGA1 can inhibit excitotoxin-induced apoptosis of striatal neurons in vivo and rotenone-induced apoptosis ofcultured SH-SY5Y cells, suggesting that PGA1 may have neuroprotective efficacy, possibly mediated by inhibition of NF-kB activation. The present study evaluated the neuroprotective potential of PGA1 and its effect on IKK/I( B/NF-kB/c-myc signaling pathway in rat models of permanent focal cerebral ischemia. METHODS Permanent middle cerebral artery occlusion (pMCAO) model was constructed by intraluminal suture cannulation through the internal carotid artery in Wistar rats.
