目的评价24 h多通道腔内阻抗-pH监测(24 h MII-pH)在胃食管反流病(GERD)诊断中的应用价值。方法选取2016年1月—2018年6月在某院就诊的326例GERD患者作为观察组,并选取同时期健康志愿者75例作为对照组,均行24 h MII-pH监测,并记录GERD...目的评价24 h多通道腔内阻抗-pH监测(24 h MII-pH)在胃食管反流病(GERD)诊断中的应用价值。方法选取2016年1月—2018年6月在某院就诊的326例GERD患者作为观察组,并选取同时期健康志愿者75例作为对照组,均行24 h MII-pH监测,并记录GERD相关参数。比较MII-pH监测与单独pH监测对GERD的诊断情况。结果①24 h pH监测结果显示,观察组各监测指标均显著高于对照组(P<0.05);②24 h MII-pH监测结果显示,除弱碱反流次数两组无明显差异(P>0.05)外,在其他指标比较中,观察组均显著高于对照组(P<0.05);③24 h MII-pH监测GERD的阳性诊断率为87.42%,与单纯食管pH监测的44.78%比较,差异有统计学意义(P<0.05)。结论24 h MII-pH可识别反流物的运动方向、酸碱性和成分,提高GERD的检出率,具有重要的临床价值。展开更多
Objective： To analyze reflux parameters by means of combined multichannel intraluminal impedance and pH （MII-pH） monitoring in patients with gastroesophageal reflux disease （GERD） symptoms off medication, and to ...Objective： To analyze reflux parameters by means of combined multichannel intraluminal impedance and pH （MII-pH） monitoring in patients with gastroesophageal reflux disease （GERD） symptoms off medication, and to find the reflux characteristics of Chinese GERD patients and the influences of gender, age, body posture, and body mass index （BMI） on gastroesophageal reflux （GER）. Methods： Between Dec. 2008 and May 2014, 125 patients with typical GERD symptoms were subjected to 24-h MII-pH monitoring. Twelve patients with normal MII-pH profiles were not considered for analysis. The reflux parameters of 113 GERD patients with abnormal Mll-pH results were analyzed. Results： （1） DeMeester scores were above the normal range in 46.90% （53/113） of GERD patients. Weakly acidic refluxes were prevalent in GERD patients, and the frequency of abnormal weakly acidic reflux was 75.22% （85/113）. The frequencies of abnormal symptom index （SI） and symptom association probability （SAP） were 19.47% （22/113） and 14.16% （16/113）, respectively. （2） The frequencies of DeMeester scores, the %time at pH〈4, and the numbers of reflux episodes and of long reflux episodes 〉5 min were significantly higher in male patients than in female patients. （3） The %time at pH〈4 was much higher during upright periods than during supine periods. During supine periods, 31.86% （36/113） of GERD patients had delayed bolus clearance time, compared with 19.47% （22/113） during upright periods. （4） The number of abnormal DeMeester scores, %time at pH〈4, and the number of acid refluxes during upright periods were significantly higher in obese GERD patients than in GERD patients with a normal BMI. Over- weight GERD patients also had many more acid refluxes during upright periods than GERD patients with a normal BMI Conclusions： Weakly acidic refluxes were prevalent in Chinese GERD patients. The factors male, gender, upright position, obesity （BMI〉25）, but not age, may increase the fre展开更多
背景:24 h多通道腔内阻抗⁃pH(24 h MII⁃pH)监测对大部分胃食管反流病(GERD)患者的诊断不明,平均夜间基线阻抗值(MNBI)对GERD的诊断价值尚有争议。目的:分析GERD患者食管各通道MNBI的特点,探讨MNBI对GERD的诊断价值。方法:回顾性分析2019...背景:24 h多通道腔内阻抗⁃pH(24 h MII⁃pH)监测对大部分胃食管反流病(GERD)患者的诊断不明,平均夜间基线阻抗值(MNBI)对GERD的诊断价值尚有争议。目的:分析GERD患者食管各通道MNBI的特点,探讨MNBI对GERD的诊断价值。方法:回顾性分析2019年5月—2021年12月于包头医学院第二附属医院疑诊为GERD并行24 h MII⁃pH监测的111例患者的临床资料,根据DeMeester标准将患者分为非GERD组和GERD组,比较两组反流参数和各通道MNBI,并分析食管远端、近端MNBI与各反流参数的相关性,以ROC曲线评估MNBI诊断GERD的敏感性和特异性。结果:GERD患者酸暴露时间百分比(AET)、DeMeester评分、总反流次数、酸反流次数、非酸反流次数均显著高于非GERD组,差异均有统计学意义(P<0.01);GERD组患者距齿状线上方3 cm、5 cm、7 cm处的MNBI、远端MNBI均显著低于非GERD组,差异均有统计学意义(P<0.01)。Spearman相关性分析发现食管远端MNBI与AET、DeMeester评分、酸反流次数、弱酸反流次数之间具有明显负相关性(P<0.05),食管近端MNBI与AET、DeMeester评分、弱酸反流次数之间具有明显负相关性(P<0.05)。ROC曲线分析结果表明,食管远端MNBI诊断GERD的AUC为0.72(95%CI:0.66~0.81,P<0.01),当临界值为1191.42Ω时,诊断GERD的敏感性为82.9%,特异性为53.9%。结论:食管远端MNBI对于GERD患者具有较好的诊断意义,可作为GERD辅助诊断的一项新阻抗指标。展开更多
目的分析胃内镜联合多通道食管腔内阻抗-p H(MⅡ-p H)监测在诊断反流性食管炎(RE)中的应用价值。方法我院胃肠功能室进行胃镜、24 h MⅡ-p H监测的220例反流性食管炎患者为观察组,同期我院体检的60例健康正常人为对照组,总结反流性食管...目的分析胃内镜联合多通道食管腔内阻抗-p H(MⅡ-p H)监测在诊断反流性食管炎(RE)中的应用价值。方法我院胃肠功能室进行胃镜、24 h MⅡ-p H监测的220例反流性食管炎患者为观察组,同期我院体检的60例健康正常人为对照组,总结反流性食管炎患者24 h MⅡ-p H临床表现,统计胃镜、24 h MⅡ-p H诊断RE阳性率。结果 24 h MⅡ-p H诊断RE阳性率高于胃镜、24 h p H-De M,胃镜+24 h MⅡ-p H诊断RE阳性率高于单纯胃镜、24 h p H-De M、24 h MⅡ-p H检查(P<0.05)。观察组立位和卧位总反流、酸反流、弱酸反流及液体反流、混合反流、气体反流中位次数均高于对照组;反流时间>5min次数、最长反流次数、总p H、立位p H、卧位p H、De M积分均高于对照组(P<0.05)。结论胃镜联合24 h MⅡ-p H监测可弥补常规胃镜诊断的不足,可明确RE患者食管反流特点及反流理化性质,对RE诊断价值较高。展开更多
文摘目的评价24 h多通道腔内阻抗-pH监测(24 h MII-pH)在胃食管反流病(GERD)诊断中的应用价值。方法选取2016年1月—2018年6月在某院就诊的326例GERD患者作为观察组,并选取同时期健康志愿者75例作为对照组,均行24 h MII-pH监测,并记录GERD相关参数。比较MII-pH监测与单独pH监测对GERD的诊断情况。结果①24 h pH监测结果显示,观察组各监测指标均显著高于对照组(P<0.05);②24 h MII-pH监测结果显示,除弱碱反流次数两组无明显差异(P>0.05)外,在其他指标比较中,观察组均显著高于对照组(P<0.05);③24 h MII-pH监测GERD的阳性诊断率为87.42%,与单纯食管pH监测的44.78%比较,差异有统计学意义(P<0.05)。结论24 h MII-pH可识别反流物的运动方向、酸碱性和成分,提高GERD的检出率,具有重要的临床价值。
文摘Objective： To analyze reflux parameters by means of combined multichannel intraluminal impedance and pH （MII-pH） monitoring in patients with gastroesophageal reflux disease （GERD） symptoms off medication, and to find the reflux characteristics of Chinese GERD patients and the influences of gender, age, body posture, and body mass index （BMI） on gastroesophageal reflux （GER）. Methods： Between Dec. 2008 and May 2014, 125 patients with typical GERD symptoms were subjected to 24-h MII-pH monitoring. Twelve patients with normal MII-pH profiles were not considered for analysis. The reflux parameters of 113 GERD patients with abnormal Mll-pH results were analyzed. Results： （1） DeMeester scores were above the normal range in 46.90% （53/113） of GERD patients. Weakly acidic refluxes were prevalent in GERD patients, and the frequency of abnormal weakly acidic reflux was 75.22% （85/113）. The frequencies of abnormal symptom index （SI） and symptom association probability （SAP） were 19.47% （22/113） and 14.16% （16/113）, respectively. （2） The frequencies of DeMeester scores, the %time at pH〈4, and the numbers of reflux episodes and of long reflux episodes 〉5 min were significantly higher in male patients than in female patients. （3） The %time at pH〈4 was much higher during upright periods than during supine periods. During supine periods, 31.86% （36/113） of GERD patients had delayed bolus clearance time, compared with 19.47% （22/113） during upright periods. （4） The number of abnormal DeMeester scores, %time at pH〈4, and the number of acid refluxes during upright periods were significantly higher in obese GERD patients than in GERD patients with a normal BMI. Over- weight GERD patients also had many more acid refluxes during upright periods than GERD patients with a normal BMI Conclusions： Weakly acidic refluxes were prevalent in Chinese GERD patients. The factors male, gender, upright position, obesity （BMI〉25）, but not age, may increase the fre
文摘背景:24 h多通道腔内阻抗⁃pH(24 h MII⁃pH)监测对大部分胃食管反流病(GERD)患者的诊断不明,平均夜间基线阻抗值(MNBI)对GERD的诊断价值尚有争议。目的:分析GERD患者食管各通道MNBI的特点,探讨MNBI对GERD的诊断价值。方法:回顾性分析2019年5月—2021年12月于包头医学院第二附属医院疑诊为GERD并行24 h MII⁃pH监测的111例患者的临床资料,根据DeMeester标准将患者分为非GERD组和GERD组,比较两组反流参数和各通道MNBI,并分析食管远端、近端MNBI与各反流参数的相关性,以ROC曲线评估MNBI诊断GERD的敏感性和特异性。结果:GERD患者酸暴露时间百分比(AET)、DeMeester评分、总反流次数、酸反流次数、非酸反流次数均显著高于非GERD组,差异均有统计学意义(P<0.01);GERD组患者距齿状线上方3 cm、5 cm、7 cm处的MNBI、远端MNBI均显著低于非GERD组,差异均有统计学意义(P<0.01)。Spearman相关性分析发现食管远端MNBI与AET、DeMeester评分、酸反流次数、弱酸反流次数之间具有明显负相关性(P<0.05),食管近端MNBI与AET、DeMeester评分、弱酸反流次数之间具有明显负相关性(P<0.05)。ROC曲线分析结果表明,食管远端MNBI诊断GERD的AUC为0.72(95%CI:0.66~0.81,P<0.01),当临界值为1191.42Ω时,诊断GERD的敏感性为82.9%,特异性为53.9%。结论:食管远端MNBI对于GERD患者具有较好的诊断意义,可作为GERD辅助诊断的一项新阻抗指标。
文摘目的分析胃内镜联合多通道食管腔内阻抗-p H(MⅡ-p H)监测在诊断反流性食管炎(RE)中的应用价值。方法我院胃肠功能室进行胃镜、24 h MⅡ-p H监测的220例反流性食管炎患者为观察组,同期我院体检的60例健康正常人为对照组,总结反流性食管炎患者24 h MⅡ-p H临床表现,统计胃镜、24 h MⅡ-p H诊断RE阳性率。结果 24 h MⅡ-p H诊断RE阳性率高于胃镜、24 h p H-De M,胃镜+24 h MⅡ-p H诊断RE阳性率高于单纯胃镜、24 h p H-De M、24 h MⅡ-p H检查(P<0.05)。观察组立位和卧位总反流、酸反流、弱酸反流及液体反流、混合反流、气体反流中位次数均高于对照组;反流时间>5min次数、最长反流次数、总p H、立位p H、卧位p H、De M积分均高于对照组(P<0.05)。结论胃镜联合24 h MⅡ-p H监测可弥补常规胃镜诊断的不足,可明确RE患者食管反流特点及反流理化性质,对RE诊断价值较高。
