Survivin(coding gene BIRC5) is a dual functional protein acting as a critical inhibitor of apoptosis(IAP) and key regulator of cell cycle progression. It is usually produced in embryonic tissues during development and...Survivin(coding gene BIRC5) is a dual functional protein acting as a critical inhibitor of apoptosis(IAP) and key regulator of cell cycle progression. It is usually produced in embryonic tissues during development and undetectable in most adult tissues.Overexpression of Survivin frequently occurs in various human cancers and increased Survivin correlates with poor clinic outcome, tumor recurrence, and therapeutic resistance. Because of its selective expression in tumor, but not normal tissues,Survivin has been recognized as an attractive target for cancer treatment. Although several therapeutic approaches targeting Survivin are actively under clinical trials in human cancers, to date no Survivin-targeted therapy has been approved for cancer treatment. Numerous studies have devoted to uncovering the underlying mechanism resulting in Survivin dysregulation at multiple levels, such as transcriptional and post-transcriptional regulation. The current article provides a literature review on the transcriptional and epigenetic regulation of Survivin expression in human cancers. We focus on the impact of DNA methylation and histone modifications, including specific lysine methylation, demethylation, and acetylation on the expression of Survivin.The latest development of epigenetic approaches targeting Survivin for cancer treatment are also discussed.展开更多
Fifty cases of regional yearly extreme precipitation events （RYEPEs） were identified over the Yangtze-Huaihe River Valley （YHRV） during 1979-2016 applying the statistical percentile method. There were five types o...Fifty cases of regional yearly extreme precipitation events （RYEPEs） were identified over the Yangtze-Huaihe River Valley （YHRV） during 1979-2016 applying the statistical percentile method. There were five types of RYEPEs, namely Yangtze Meiyu （YM-RYEPE）, Huaihe Meiyu （HM-RYEPE）, southwest-northeast-oriented Meiyu （SWNE-RYEPE） and typhoon I and II （TC-RYEPE） types of RYEPEs. Potential vorticity diagnosis showed that propagation trajectories of the RYEPEs along the Western Pacific Subtropical High and its steering flow were concentrated over the southern YHRV. As a result, the strongest and most frequently RYEPEs events, about 16-21 cases with average rainfall above 100 mm, occurred in the southern YHRV, particularly in the Nanjing metropolitan area. There have been 14 cases of flood-inducing RYEPEs since 1979, with the submerged area exceeding 120 km2 as simulated by the FloodArea hydraulic model, comprising six HM-RYEPEs, five YM- RYEPEs, two TC-RYEPEs, and one SWNE-RYEPE. The combination of evolving RYEPEs and rapid expansion of urban agglomeration is most likely to change the flood risk distribution over the Nanjing metropolitan area in the future. In the RCP6.0 （RCPS.5） scenario, the built-up area increases at a rate of about 10.41 km2 （10 yr）-t（24.67 km2 （10 yr）-1） from 2010 to 2100, and the area of high flood risk correspondingly increases from 3.86 km2（3.86 km2） to 9.00 kin2（13.51 km2）. Areas of high flood risk are mainly located at Chishan Lake in Jurong, Lukou International Airport in Nanjing, Dongshan in Jiangning District, Lishui District and other low-lying areas. The accurate simulation of flood scenarios can help reduce losses due to torrential flooding and improve early warnings, evacuation planning and risk analysis. More attention should be paid to the projected high flood risk because of the concentrated population, industrial zones and social wealth throughout the Nanjing metropolitan area.展开更多
基金supported by the National Institutes of Health/National Cancer Institute(NIH/NCI)(R01CA201011)the National Natural Science Foundation of China(81472763 to Bolin Liu)
文摘Survivin(coding gene BIRC5) is a dual functional protein acting as a critical inhibitor of apoptosis(IAP) and key regulator of cell cycle progression. It is usually produced in embryonic tissues during development and undetectable in most adult tissues.Overexpression of Survivin frequently occurs in various human cancers and increased Survivin correlates with poor clinic outcome, tumor recurrence, and therapeutic resistance. Because of its selective expression in tumor, but not normal tissues,Survivin has been recognized as an attractive target for cancer treatment. Although several therapeutic approaches targeting Survivin are actively under clinical trials in human cancers, to date no Survivin-targeted therapy has been approved for cancer treatment. Numerous studies have devoted to uncovering the underlying mechanism resulting in Survivin dysregulation at multiple levels, such as transcriptional and post-transcriptional regulation. The current article provides a literature review on the transcriptional and epigenetic regulation of Survivin expression in human cancers. We focus on the impact of DNA methylation and histone modifications, including specific lysine methylation, demethylation, and acetylation on the expression of Survivin.The latest development of epigenetic approaches targeting Survivin for cancer treatment are also discussed.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41205063 & 41330529)the China Meteorological Administration Special Public Welfare Research Fund (Grant No. GYHY201506006)+1 种基金the Project of Development of Key Techniques in Meteorological Forecasting Operation (Grant No. CMAHX20160404)the Huaihe Basin Meteorological Research Foundation (Grant No. HRM201605)
文摘Fifty cases of regional yearly extreme precipitation events （RYEPEs） were identified over the Yangtze-Huaihe River Valley （YHRV） during 1979-2016 applying the statistical percentile method. There were five types of RYEPEs, namely Yangtze Meiyu （YM-RYEPE）, Huaihe Meiyu （HM-RYEPE）, southwest-northeast-oriented Meiyu （SWNE-RYEPE） and typhoon I and II （TC-RYEPE） types of RYEPEs. Potential vorticity diagnosis showed that propagation trajectories of the RYEPEs along the Western Pacific Subtropical High and its steering flow were concentrated over the southern YHRV. As a result, the strongest and most frequently RYEPEs events, about 16-21 cases with average rainfall above 100 mm, occurred in the southern YHRV, particularly in the Nanjing metropolitan area. There have been 14 cases of flood-inducing RYEPEs since 1979, with the submerged area exceeding 120 km2 as simulated by the FloodArea hydraulic model, comprising six HM-RYEPEs, five YM- RYEPEs, two TC-RYEPEs, and one SWNE-RYEPE. The combination of evolving RYEPEs and rapid expansion of urban agglomeration is most likely to change the flood risk distribution over the Nanjing metropolitan area in the future. In the RCP6.0 （RCPS.5） scenario, the built-up area increases at a rate of about 10.41 km2 （10 yr）-t（24.67 km2 （10 yr）-1） from 2010 to 2100, and the area of high flood risk correspondingly increases from 3.86 km2（3.86 km2） to 9.00 kin2（13.51 km2）. Areas of high flood risk are mainly located at Chishan Lake in Jurong, Lukou International Airport in Nanjing, Dongshan in Jiangning District, Lishui District and other low-lying areas. The accurate simulation of flood scenarios can help reduce losses due to torrential flooding and improve early warnings, evacuation planning and risk analysis. More attention should be paid to the projected high flood risk because of the concentrated population, industrial zones and social wealth throughout the Nanjing metropolitan area.
