A highly efficient three-component reaction has been developed for the synthesis of thiazolidinones involving the reaction of 2-amino-l-phenylethanone hydrochloride with an aromatic aldehyde and mercaptoacetic acid in...A highly efficient three-component reaction has been developed for the synthesis of thiazolidinones involving the reaction of 2-amino-l-phenylethanone hydrochloride with an aromatic aldehyde and mercaptoacetic acid in the presence of diisopropylethylamine in a single pot.Critically,this reaction exhibited excellent chemoselectivity,with the nitrogen atom of the 2-amino-l-phenylethanone component reacting selectively with the aromatic aldehyde to give the corresponding Schiff base.Nucleophilic attack at the carbon of the Schiff base by the sulfur atom of mercaptoacetic,followed by a cyclocondensation reaction between the nitrogen and the carboxylic acid moiety afforded the desired thiazolidinones,which were fully characterized by spectroscopic techniques.展开更多
146：123703x使用含时密度动能理论来研究部花青染料的紫外光／可见光吸收光谱Guillaume，Maxime等（比利时那斯慕尔巴黎圣母院Paix大学院系应用化学理论实验室，B一5000）Journal of Physics Chemistry A，2006，110（48）：13007—13...146：123703x使用含时密度动能理论来研究部花青染料的紫外光／可见光吸收光谱Guillaume，Maxime等（比利时那斯慕尔巴黎圣母院Paix大学院系应用化学理论实验室，B一5000）Journal of Physics Chemistry A，2006，110（48）：13007—13013（英文）
用实验方法测定了一组11个部花青染料的可见光谱性能，并使用含时密度功能理论计算比较了其理论估算值。研究了三族部花青类，第一族5个部花青类染料，含有与不同供电子团相谐调的4-噻唑烷酮、2-硫基团；展开更多
基金supported by Special Assistance Programme SAP,University Grants Commission,New Delhi,India
文摘A highly efficient three-component reaction has been developed for the synthesis of thiazolidinones involving the reaction of 2-amino-l-phenylethanone hydrochloride with an aromatic aldehyde and mercaptoacetic acid in the presence of diisopropylethylamine in a single pot.Critically,this reaction exhibited excellent chemoselectivity,with the nitrogen atom of the 2-amino-l-phenylethanone component reacting selectively with the aromatic aldehyde to give the corresponding Schiff base.Nucleophilic attack at the carbon of the Schiff base by the sulfur atom of mercaptoacetic,followed by a cyclocondensation reaction between the nitrogen and the carboxylic acid moiety afforded the desired thiazolidinones,which were fully characterized by spectroscopic techniques.
